protein coding gene - gpa1 (SPBC24C6.06) - G-protein alpha subunit

Gene summary

Standard name

gpa1

Systematic ID

SPBC24C6.06

Product

G-protein alpha subunit

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

P27584

ORFeome ID

32/32F08

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 2329710..2331890 forward strand

Annotation

Protein features

Orthologs

• GNAO1 (HGNC:4389) Homo sapiens
• gpa1 (SJAG_02233) Schizosaccharomyces japonicus
• GPA1 (YHR005C) Saccharomyces cerevisiae

References / Literature

PMID:1883874 - sar1, a gene from Schizosaccharomyces pombe encoding a protein that regulates ras1.

Wang Y et al. Cell Regul 1991 Jun;2(6):453-65

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:8196631 - Analysis of the structural genes encoding M-factor in the fission yeast Schizosaccharomyces pombe: identification of a third gene, mfm3.

Kjaerulff S et al. Mol Cell Biol 1994 Jun;14(6):3895-905

PMID:16884933 - Identification of Gnr1p, a negative regulator of G alpha signalling in Schizosaccharomyces pombe, and its complementation by human G beta subunits.

Goddard A et al. Fungal Genet Biol 2006 Dec;43(12):840-51

PMID:8534915 - Schizosaccharomyces pombe zfs1+ encoding a zinc-finger protein functions in the mating pheromone recognition pathway.

Kanoh J et al. Mol Biol Cell 1995 Sep;6(9):1185-95

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:8804400 - The G protein beta subunit Gpb1 of Schizosaccharomyces pombe is a negative regulator of sexual development.

Kim DU et al. Mol Gen Genet 1996 Aug 27;252(1-2):20-32

PMID:8443406 - Functional homology of protein kinases required for sexual differentiation in Schizosaccharomyces pombe and Saccharomyces cerevisiae suggests a conserved signal transduction module in eukaryotic organisms.

Neiman AM et al. Mol Biol Cell 1993 Jan;4(1):107-20

PMID:10747045 - The fission yeast git5 gene encodes a Gbeta subunit required for glucose-triggered adenylate cyclase activation.

Landry S et al. Genetics 2000 Apr;154(4):1463-71

PMID:22633491 - Mapping N-glycosylation sites across seven evolutionarily distant species reveals a divergent substrate proteome despite a common core machinery.

Zielinska DF et al. Mol Cell 2012 May 25;46(4):542-8

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

GO_REF:0000002 - Comments

PMID:15659165 - A constitutively active GPCR retains its G protein specificity and the ability to form dimers.

Ladds G et al. Mol Microbiol 2005 Jan;55(2):482-97

PMID:8335253 - Identification and genetic analysis of Schizosaccharomyces pombe cDNAs that suppress deletion of IRA1 in Saccharomyces cerevisiae.

Matviw H et al. Gene 1993 Jul 15;129(1):147-52

PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.

Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:7975894 - Mating pheromone-induced expression of the mat1-Pm gene of Schizosaccharomyces pombe: identification of signalling components and characterization of upstream controlling elements.

Aono T et al. Yeast 1994 Jun;10(6):757-70

PMID:8264618 - Concerted action of RAS and G proteins in the sexual response pathways of Schizosaccharomyces pombe.

Xu HP et al. Mol Cell Biol 1994 Jan;14(1):50-8

PMID:23950735 - Global analysis of fission yeast mating genes reveals new autophagy factors.

Sun LL et al. PLoS Genet 2013;9(8):e1003715

PMID:8816472 - Identification of Ste4 as a potential regulator of Byr2 in the sexual response pathway of Schizosaccharomyces pombe.

Barr MM et al. Mol Cell Biol 1996 Oct;16(10):5597-603

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:11461899 - Isolation of a novel gene from Schizosaccharomyces pombe: stm1+ encoding a seven-transmembrane loop protein that may couple with the heterotrimeric Galpha 2 protein, Gpa2.

Chung KS et al. J Biol Chem 2001 Oct 26;276(43):40190-201

PMID:27798845 - Spatial focalization of pheromone/MAPK signaling triggers commitment to cell-cell fusion.

Dudin O et al. Genes Dev 2016 Oct 01;30(19):2226-2239

PMID:1905818 - Isolation and characterization of a gene encoding a G-protein alpha subunit from Schizosaccharomyces pombe: involvement in mating and sporulation pathways.

Obara T et al. Proc Natl Acad Sci U S A 1991 Jul 01;88(13):5877-81

PMID:9315645 - Multiple regulatory domains on the Byr2 protein kinase.

Tu H et al. Mol Cell Biol 1997 Oct;17(10):5876-87

PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.

UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.

Mata J et al. Nat Genet 2002 Sep;32(1):143-7

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:24192486 - The conserved Fanconi anemia nuclease Fan1 and the SUMO E3 ligase Pli1 act in two novel Pso2-independent pathways of DNA interstrand crosslink repair in yeast.

Fontebasso Y et al. DNA Repair (Amst) 2013 Dec;12(12):1011-23

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:27020743 - Local Pheromone Release from Dynamic Polarity Sites Underlies Cell-Cell Pairing during Yeast Mating.

Merlini L et al. Curr Biol 2016 Apr 25;26(8):1117-25

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:35820914 - Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging.

Vega M et al. BMC Biol 2022 Jul 12;20(1):160

PMID:19285552 - Dual positive and negative regulation of GPCR signaling by GTP hydrolysis.

Smith B et al. Cell Signal 2009 Jul;21(7):1151-60

PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.

Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684

PMID:41844616 - Phosphoregulation of the novel hemi-arrestin MAPK scaffold Sms1 prevents untimely mating.

Sieber B et al. Nat Commun 2026 Mar 17;

PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.

Paulo JA et al. J Proteomics 2020 Jan 06;210:103531

PMID:8314086 - The fission yeast mating pheromone P-factor: its molecular structure, gene structure, and ability to induce gene expression and G1 arrest in the mating partner.

Imai Y et al. Genes Dev 1994 Feb 01;8(3):328-38

PMID:23843946 - The role of the RACK1 ortholog Cpc2p in modulating pheromone-induced cell cycle arrest in fission yeast.

Mos M et al. PLoS One 2013;8(7):e65927