protein coding gene - cdc14 (SPBC24C6.07) - SIN component Cdc14

Gene summary

Standard name

cdc14

Systematic ID

SPBC24C6.07

Product

SIN component Cdc14

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

P36589

ORFeome ID

31/31H04

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 2332126..2335029 forward strand

Annotation

Protein features

Orthologs

• cdc14 (SJAG_02232) Schizosaccharomyces japonicus

References / Literature

PMID:10503548 - Analysis of the cps1 gene provides evidence for a septation checkpoint in Schizosaccharomyces pombe.

Le Goff X et al. Mol Gen Genet 1999 Aug;262(1):163-72

PMID:11791728 - Radicicol binding to Swo1/Hsp90 and inhibition of growth of specific temperature-sensitive cell cycle mutants of fission yeast.

Ki SW et al. Biosci Biotechnol Biochem 2001 Nov;65(11):2528-34

PMID:12796296 - Scw1p antagonizes the septation initiation network to regulate septum formation and cell separation in the fission yeast Schizosaccharomyces pombe.

Jin QW et al. Eukaryot Cell 2003 Jun;2(3):510-20

PMID:24006256 - Fission yeast nucleolar protein Dnt1 regulates G2/M transition and cytokinesis by downregulating Wee1 kinase.

Yu ZY et al. J Cell Sci 2013 Nov 01;126(Pt 21):4995-5004

PMID:10769201 - The S. pombe orthologue of the S. cerevisiae mob1 gene is essential and functions in signalling the onset of septum formation.

Salimova E et al. J Cell Sci 2000 May;113 ( Pt 10):1695-704

PMID:11271422 - Bypass of the requirement for cdc16p GAP function in Schizosaccharomyces pombe by mutation of the septation initiation network genes.

Fournier N et al. Arch Microbiol 2001 Jan;175(1):62-9

PMID:12791993 - Equatorial retention of the contractile actin ring by microtubules during cytokinesis.

Pardo M et al. Science 2003 Jun 06;300(5625):1569-74

PMID:15537703 - The nuclear kinase Lsk1p positively regulates the septation initiation network and promotes the successful completion of cytokinesis in response to perturbation of the actomyosin ring in Schizosaccharomyces pombe.

Karagiannis J et al. Mol Biol Cell 2005 Jan;16(1):358-71

PMID:8334307 - The Schizosaccharomyces pombe cdc14 gene is required for septum formation and can also inhibit nuclear division.

Fankhauser C et al. Mol Biol Cell 1993 May;4(5):531-9

PMID:10837231 - Mob1p interacts with the Sid2p kinase and is required for cytokinesis in fission yeast.

Hou MC et al. Curr Biol 2000 May 18;10(10):619-22

PMID:8039497 - The cdc7 protein kinase is a dosage dependent regulator of septum formation in fission yeast.

Fankhauser C et al. EMBO J 1994 Jul 01;13(13):3011-9

PMID:10805785 - Sid4p is required to localize components of the septation initiation pathway to the spindle pole body in fission yeast.

Chang L et al. Proc Natl Acad Sci U S A 2000 May 09;97(10):5249-54

PMID:24790095 - Characterization of the roles of Blt1p in fission yeast cytokinesis.

Goss JW et al. Mol Biol Cell 2014 Jul 01;25(13):1946-57

PMID:7634333 - The S. pombe cdc15 gene is a key element in the reorganization of F-actin at mitosis.

Fankhauser C et al. Cell 1995 Aug 11;82(3):435-44

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:10775265 - The role of the sid1p kinase and cdc14p in regulating the onset of cytokinesis in fission yeast.

Guertin DA et al. EMBO J 2000 Apr 17;19(8):1803-15

PMID:10459013 - Sid2p, a spindle pole body kinase that regulates the onset of cytokinesis.

Sparks CA et al. J Cell Biol 1999 Aug 23;146(4):777-90

PMID:9398685 - Identification of a second myosin-II in Schizosaccharomyces pombe: Myp2p is conditionally required for cytokinesis.

Bezanilla M et al. Mol Biol Cell 1997 Dec;8(12):2693-705

PMID:16467379 - Actin-depolymerizing protein Adf1 is required for formation and maintenance of the contractile ring during cytokinesis in fission yeast.

Nakano K et al. Mol Biol Cell 2006 Apr;17(4):1933-45

PMID:9649519 - Isolation and characterization of new fission yeast cytokinesis mutants.

Balasubramanian MK et al. Genetics 1998 Jul;149(3):1265-75

PMID:12242222 - The Scw1 RNA-binding domain protein regulates septation and cell-wall structure in fission yeast.

Karagiannis J et al. Genetics 2002 Sep;162(1):45-58

PMID:10545452 - Drc1p/Cps1p, a 1,3-beta-glucan synthase subunit, is essential for division septum assembly in Schizosaccharomyces pombe.

Liu J et al. Genetics 1999 Nov;153(3):1193-203

PMID:11707284 - The protein phosphatase 2A B'-regulatory subunit par1p is implicated in regulation of the S. pombe septation initiation network.

Le Goff X et al. FEBS Lett 2001 Nov 09;508(1):136-42

PMID:11514436 - Correct regulation of the septation initiation network in Schizosaccharomyces pombe requires the activities of par1 and par2.

Jiang W et al. Genetics 2001 Aug;158(4):1413-29

PMID:12354095 - Calcineurin is implicated in the regulation of the septation initiation network in fission yeast.

Lu Y et al. Genes Cells 2002 Oct;7(10):1009-19

PMID:31474649 - Identification of 15 New Bypassable Essential Genes of Fission Yeast.

Takeda A et al. Cell Struct Funct 2019 Sep 27;44(2):113-119

PMID:1527180 - Genetic interactions in the control of septation in Schizosaccharomyces pombe.

Marks J et al. J Cell Sci 1992 Apr;101 ( Pt 4):801-8

PMID:15517003 - Organization of a sterol-rich membrane domain by cdc15p during cytokinesis in fission yeast.

Takeda T et al. Nat Cell Biol 2004 Nov;6(11):1142-4

PMID:9573052 - Pom1p, a fission yeast protein kinase that provides positional information for both polarized growth and cytokinesis.

Bähler J et al. Genes Dev 1998 May 01;12(9):1356-70

PMID:22267499 - Characterization of ypa1 and ypa2, the Schizosaccharomyces pombe orthologs of the peptidyl proyl isomerases that activate PP2A, reveals a role for Ypa2p in the regulation of cytokinesis.

Goyal A et al. Genetics 2012 Apr;190(4):1235-50

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:11683392 - Flp1, a fission yeast orthologue of the s. cerevisiae CDC14 gene, is not required for cyclin degradation or rum1p stabilisation at the end of mitosis.

Cueille N et al. J Cell Sci 2001 Jul;114(Pt 14):2649-64

PMID:16415366 - A role for the septation initiation network in septum assembly revealed by genetic analysis of sid2-250 suppressors.

Jin QW et al. Genetics 2006 Apr;172(4):2101-12

PMID:15265986 - The Clp1p/Flp1p phosphatase ensures completion of cytokinesis in response to minor perturbation of the cell division machinery in Schizosaccharomyces pombe.

Mishra M et al. J Cell Sci 2004 Aug 01;117(Pt 17):3897-910

PMID:17538026 - The nucleolar Net1/Cfi1-related protein Dnt1 antagonizes the septation initiation network in fission yeast.

Jin QW et al. Mol Biol Cell 2007 Aug;18(8):2924-34

PMID:9203579 - The Spg1p GTPase is an essential, dosage-dependent inducer of septum formation in Schizosaccharomyces pombe.

Schmidt S et al. Genes Dev 1997 Jun 15;11(12):1519-34

PMID:958201 - Genetic control of the cell division cycle in the fission yeast Schizosaccharomyces pombe.

Nurse P et al. Mol Gen Genet 1976 Jul 23;146(2):167-78

PMID:10462526 - The S. pombe zfs1 gene is required to prevent septation if mitotic progression is inhibited.

Beltraminelli N et al. J Cell Sci 1999 Sep;112 Pt 18:3103-14

PMID:17502918 - A cyclin-dependent kinase that promotes cytokinesis through modulating phosphorylation of the carboxy terminal domain of the RNA Pol II Rpb1p sub-unit.

Karagiannis J et al. PLoS One 2007 May 09;2(5):e433

PMID:19237545 - The fission yeast SEL1 domain protein Cfh3p: a novel regulator of the glucan synthase Bgs1p whose function is more relevant under stress conditions.

Sharifmoghadam MR et al. J Biol Chem 2009 Apr 24;284(17):11070-9

PMID:20805322 - The mitosis-to-interphase transition is coordinated by cross talk between the SIN and MOR pathways in Schizosaccharomyces pombe.

Ray S et al. J Cell Biol 2010 Sep 06;190(5):793-805

PMID:20876564 - Antagonistic roles of PP2A-Pab1 and Etd1 in the control of cytokinesis in fission yeast.

Lahoz A et al. Genetics 2010 Dec;186(4):1261-70

PMID:21131906 - Dma1 ubiquitinates the SIN scaffold, Sid4, to impede the mitotic localization of Plo1 kinase.

Johnson AE et al. EMBO J 2011 Jan 19;30(2):341-54

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:8524294 - Schizosaccharomyces pombe skp1+ encodes a protein kinase related to mammalian glycogen synthase kinase 3 and complements a cdc14 cytokinesis mutant.

Plyte SE et al. Mol Cell Biol 1996 Jan;16(1):179-91

PMID:11384993 - Interaction between the noncatalytic region of Sid1p kinase and Cdc14p is required for full catalytic activity and localization of Sid1p.

Guertin DA et al. J Biol Chem 2001 Jul 27;276(30):28185-9

PMID:35099006 - Fission yeast polycystin Pkd2p promotes cell size expansion and antagonizes the Hippo-related SIN pathway.

Sinha D et al. J Cell Sci 2022 Feb 15;135(4)

PMID:9254700 - Sce3, a suppressor of the Schizosaccharomyces pombe septation mutant cdc11, encodes a putative RNA-binding protein.

Schmidt S et al. Nucleic Acids Res 1997 Sep 01;25(17):3433-9

PMID:38989013 - Characterization of temperature-sensitive alleles of Schizosaccharomyces pombe septation initiation network components.

Turner LA et al. MicroPubl Biol 2024;2024

PMID:11694585 - Interactions among a fimbrin, a capping protein, and an actin-depolymerizing factor in organization of the fission yeast actin cytoskeleton.

Nakano K et al. Mol Biol Cell 2001 Nov;12(11):3515-26