protein coding gene - mam1 (SPBC25B2.02c) - M-factor transmembrane transporter Mam1

Gene summary

Standard name

mam1

Systematic ID

SPBC25B2.02c

Product

M-factor transmembrane transporter Mam1

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

SPBC2G5.09c

UniProt ID

P78966

ORFeome ID

34/34B02

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 2596405..2600486 reverse strand

Annotation

Protein features

Orthologs

• mam1 (SJAG_02602) Schizosaccharomyces japonicus
• STE6 (YKL209C) Saccharomyces cerevisiae

References / Literature

PMID:7900424 - Assessment of pheromone production and response in fission yeast by a halo test of induced sporulation.

Egel R et al. Yeast 1994 Oct;10(10):1347-54

PMID:39094565 - Mapping the dynamics of epigenetic adaptation in S. pombe during heterochromatin misregulation.

Larkin A et al. Dev Cell 2024 Jul 26;

PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.

Paulo JA et al. J Proteomics 2020 Jan 06;210:103531

PMID:23521895 - Chemical genetic screen in fission yeast reveals roles for vacuolar acidification, mitochondrial fission, and cellular GMP levels in lifespan extension.

Stephan J et al. Aging Cell 2013 Aug;12(4):574-83

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:9236781 - The Schizosaccharomyces pombe mam1 gene encodes an ABC transporter mediating secretion of M-factor.

Christensen PU et al. Mol Gen Genet 1997 Jun;255(2):226-36

GO_REF:0000002 - Comments

PMID:24727291 - A genome-wide screen for sporulation-defective mutants in Schizosaccharomyces pombe.

Ucisik-Akkaya E et al. G3 (Bethesda) 2014 Apr 11;4(6):1173-82

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.

Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80

PMID:27020743 - Local Pheromone Release from Dynamic Polarity Sites Underlies Cell-Cell Pairing during Yeast Mating.

Merlini L et al. Curr Biol 2016 Apr 25;26(8):1117-25

PMID:16288715 - Alternative protein secretion: the Mam1 ABC transporter supports secretion of M-factor linked GFP in fission yeast.

Kjaerulff S et al. Biochem Biophys Res Commun 2005 Dec 30;338(4):1853-9

PMID:22840777 - Analyzing fission yeast multidrug resistance mechanisms to develop a genetically tractable model system for chemical biology.

Kawashima SA et al. Chem Biol 2012 Jul 27;19(7):893-901

PMID:25452419 - Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.

Sideri T et al. G3 (Bethesda) 2014 Dec 01;5(1):145-55

PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.

UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531

PMID:23861937 - Genome-wide screening for genes associated with valproic acid sensitivity in fission yeast.

Zhang L et al. PLoS One 2013;8(7):e68738

PMID:8380233 - Schizosaccharomyces pombe map3+ encodes the putative M-factor receptor.

Tanaka K et al. Mol Cell Biol 1993 Jan;13(1):80-8

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:21340088 - Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.

Arita Y et al. Mol Biosyst 2011 May;7(5):1463-72

PMID:16849797 - A survey of all 11 ABC transporters in fission yeast: two novel ABC transporters are required for red pigment accumulation in a Schizosaccharomyces pombe adenine biosynthetic mutant.

Iwaki T et al. Microbiology (Reading) 2006 Aug;152(Pt 8):2309-2321

PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.

Blyth J et al. Genetics 2018 Feb;208(2):589-603

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:21297349 - Bfr1p is responsible for tributyltin resistance in Schizosaccharomyces pombe.

Akiyama K et al. J Toxicol Sci 2011 Jan;36(1):117-20

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:4716873 - Genes involved in mating type expression of fission yeast.

Egel R Mol Gen Genet 1973 May 28;122(4):339-43

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:25117315 - A potential protective role for thiamine in glucose-driven oxidative stress.

Palabiyik B et al. Genet Mol Res 2014 Jul 25;13(3):5582-93

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:9191268 - Identification of the transporter for the M-factor mating pheromone in fission yeast.

Davey J et al. Biochem Soc Trans 1997 May;25(2):224S

PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.

Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684