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protein coding gene - pof2 (SPBC25B2.11) - F-box protein Pof2

Gene summary

Standard name
pof2
Systematic ID
SPBC25B2.11
Product
F-box protein Pof2
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O74783
ORFeome ID
44/44G08
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 2617862..2619476 forward strand

Annotation

GO biological process

GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

References:

GO cellular component

GO:0005737 - cytoplasm

References:

GO:0019005 - SCF ubiquitin ligase complex

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GO molecular function

GO:0005515 - protein binding

References:

GO:1990756 - ubiquitin-like ligase-substrate adaptor activity

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Protein features

PBO:0111823 - F-box protein

PBO:0111865 - leucine-rich repeat protein

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0002693 - resistance to diamide

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0001034 - resistance to tunicamycin

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Genotypes:

FYPO:0000785 - sensitive to formamide

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Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF13516LRR_6Leu-rich_rptPFAM
PF12937F-box-likeF-box_domPFAM
PS50181FBOXF-box_domPROSITE_PROFILES
SM00367LRR_CC_2Leu-rich_rpt_Cys-con_subtypSMART
G3DSA:3.80.10.10:FF:002830FUNFAM
SSF52047RNI-likeSUPERFAMILY
SSF81383F-box domainF-box-like_dom_sfSUPERFAMILY
G3DSA:3.80.10.10Ribonuclease InhibitorLRR_dom_sfGENE3D
PTHR13318PARTNER OF PAIRED, ISOFORM B-RELATEDPANTHER

Orthologs

References / Literature

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:28974540 - The fission yeast nucleoporin Alm1 is required for proteasomal degradation of kinetochore components.
Salas-Pino S et al. J Cell Biol 2017 Nov 06;216(11):3591-3608
PMID:15147268 - Molecular interactions of fission yeast Skp1 and its role in the DNA damage checkpoint.
Lehmann A et al. Genes Cells 2004 May;9(5):367-82
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:26670050 - Regulation of mRNA Levels by Decay-Promoting Introns that Recruit the Exosome Specificity Factor Mmi1.
Kilchert C et al. Cell Rep 2015 Dec 22;13(11):2504-2515
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12