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protein coding gene - tim22 (SPBC25H2.04c) - TIM22 inner membrane protein insertion complex insertase subunit Tim22

Gene summary

Standard name
tim22
Systematic ID
SPBC25H2.04c
Product
TIM22 inner membrane protein insertion complex insertase subunit Tim22
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
P87146
ORFeome ID
05/05C11
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 3275629..3276791 forward strand

Annotation

Disease association

MONDO:0030017 - combined oxidative phosphorylation deficiency 43

References:

GO biological process

GO:7770061 - TOM-TIM22-mediated mitochondrial inner membrane protein insertion

References:

GO cellular component

GO:0005739 - mitochondrion

References:

GO:0042721 - TIM22 mitochondrial import inner membrane insertion complex

References:

GO molecular function

GO:0032977 - membrane insertase activity

References:

GO:0030943 - mitochondrion targeting sequence binding

References:

GO:0008320 - transmembrane protein transporter activity

References:

Modification

MOD:00689 - disulfide crosslinked residues

References:

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000320 - inviable after spore germination, single cell division, normal cell morphology

References:

Genotypes:

FYPO:0000310 - inviable after spore germination, without cell division, with normal germ tube morphology

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF02466Tim17PFAM
PTHR14110MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22TIM22PANTHER
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder
mobidb-lite-Low-complexitydisorder_predictionMOBIDB-Low-complexity

Orthologs

References / Literature

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:36478272 - Translation-complex profiling of fission yeast cells reveals dynamic rearrangements of scanning ribosomal subunits upon nutritional stress.
Duncan CDS et al. Nucleic Acids Res 2022 Dec 09;50(22):13011-13025
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:39753782 - Dbi1 is an oxidoreductase and an assembly chaperone for mitochondrial inner membrane proteins.
Badrie S et al. EMBO Rep 2025 Feb;26(4):911-928
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7