protein coding gene - tif11 (SPBC25H2.07) - translation initiation factor eIF1A

Gene summary

Standard name: tif11
Systematic ID: SPBC25H2.07
Product: translation initiation factor eIF1A
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: P55877
ORFeome ID: 39/39G10
Characterisation status: biological role published
Feature type: mRNA gene
Genomic location: chromosome II: 3271874..3272716 reverse strand

Annotation

GO biological process

GO:0002183 - cytoplasmic translational initiation

References:

GO_REF:0000024

GO cellular component

GO:0005829 - cytosol

References:

PMID:16823372

GO molecular function

GO:0003725 - double-stranded RNA binding

References:

PMID:17673174

GO:0033592 - RNA strand annealing activity

References:

PMID:17673174

GO:0003743 - translation initiation factor activity

References:

GO_REF:0000033

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

References:

PMID:23697806

Genotypes:

tif11delta

FYPO:0002151 - inviable spore

References:

PMID:23697806

Genotypes:

tif11delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

tif11delta

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF01176	eIF-1a	RNA-binding_domain_S1_IF1	PFAM
cd05793	S1_IF1A	TIF_eIF-1A	CDD
PS01262	IF1A	TIF_eIF-1A_CS	PROSITE_PATTERNS
PS50832	S1_IF1_TYPE	RNA-binding_domain_S1_IF1	PROSITE_PROFILES
SM00652	eIF1neu4	TIF_eIF-1A	SMART
G3DSA:2.40.50.140:FF:000071			FUNFAM
SSF50249	Nucleic acid-binding proteins	NA-bd_OB-fold	SUPERFAMILY
G3DSA:2.40.50.140		NA-bd_OB-fold	GENE3D
PTHR21668	EIF-1A	TIF_eIF-1A	PANTHER
MF_00216	aIF_1A	TIF_eIF-1A	HAMAP
mobidb-lite-Disorder	disorder_prediction		MOBIDB-Disorder
mobidb-lite-Polyampholyte	disorder_prediction		MOBIDB-Polyampholyte
mobidb-lite-Positive-Polyelectrolyte	disorder_prediction		MOBIDB-Positive-Polyelectrolyte
TIGR00523	eIF-1A	TIF_eIF-1A	NCBIFAM

Orthologs

EIF1AX (HGNC:3250) Homo sapiens
EIF1AY (HGNC:3252) Homo sapiens
tif11 (SJAG_01643) Schizosaccharomyces japonicus
TIF11 (YMR260C) Saccharomyces cerevisiae

References / Literature

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:17673174 - Translation initiation factor eIF1A possesses RNA annealing activity in its oligonucleotide-binding fold.: Kwon SH et al. Biochem Biophys Res Commun 2007 Sep 28;361(3):681-6
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.: Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.: Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.: Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:30355493 - Expanded Interactome of the Intrinsically Disordered Protein Dss1.: Schenstrøm SM et al. Cell Rep 2018 Oct 23;25(4):862-870
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.: Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.: Paulo JA et al. J Proteomics 2020 Jan 06;210:103531
PMID:19336419 - Cotranscriptional recruitment of the nuclear poly(A)-binding protein Pab2 to nascent transcripts and association with translating mRNPs.: Lemieux C et al. Nucleic Acids Res 2009 Jun;37(10):3418-30
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.: Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105