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protein coding gene - spt7 (SPBC25H2.11c) - SAGA complex bromodomain subunit Spt7

Gene summary

Standard name
spt7
Systematic ID
SPBC25H2.11c
Product
SAGA complex bromodomain subunit Spt7
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
P87152
ORFeome ID
30/30D05
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 3263270..3266875 forward strand

Annotation

Comment

PBO:0000206 - deletion mutant expression profiling

References:

Disease association

MONDO:0700301 - Fischer-Zirnsak progeroid syndrome

References:

GO biological process

GO:0006357 - regulation of transcription by RNA polymerase II

References:

GO:0045815 - transcription initiation-coupled chromatin remodeling

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GO cellular component

GO:0000785 - chromatin

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GO:0005634 - nucleus

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GO:0005721 - pericentric heterochromatin

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GO:0000124 - SAGA complex

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GO molecular function

GO:0140378 - protein complex scaffold activity

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GO:0003713 - transcription coactivator activity

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Modification

MOD:00046 - O-phospho-L-serine

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MOD:00047 - O-phospho-L-threonine

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MOD:00696 - phosphorylated residue

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MOD:01149 - sumoylated lysine

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Multi-locus phenotype

FYPO:0006060 - abolished protein localization to septin ring

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Genotypes:

FYPO:0000134 - branched, elongated, multiseptate cell

References:

Genotypes:

FYPO:0001252 - multinucleate multiseptate vegetative cell

References:

Genotypes:

Protein features

PBO:0111788 - bromodomain

PBO:0111763 - histone fold

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0006060 - abolished protein localization to septin ring

References:

Genotypes:

FYPO:0001512 - branched, elongated cell

References:

Genotypes:

FYPO:0000082 - decreased cell population growth at high temperature

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Genotypes:

FYPO:0004903 - decreased level of cell separation after cytokinesis gene mRNA during vegetative growth

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Genotypes:

FYPO:0000708 - decreased mating efficiency

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Genotypes:

FYPO:0001117 - decreased RNA level during vegetative growth

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Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0000223 - elongated multiseptate vegetative cell

References:

Genotypes:

FYPO:0002317 - increased cellular squalene level

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Genotypes:

FYPO:0001252 - multinucleate multiseptate vegetative cell

References:

Genotypes:

FYPO:0002567 - normal centromeric outer repeat transcript level

References:

Genotypes:

FYPO:0004742 - normal chromatin silencing at centromere outer repeat

References:

Genotypes:

FYPO:0000962 - normal growth on hydrogen peroxide

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Genotypes:

FYPO:0000957 - normal growth on methyl methanesulfonate

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Genotypes:

FYPO:0000097 - sensitive to caffeine during vegetative growth

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Genotypes:

FYPO:0000099 - sensitive to canavanine

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Genotypes:

FYPO:0001245 - sensitive to cobalt

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Genotypes:

FYPO:0000104 - sensitive to cycloheximide

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Genotypes:

FYPO:0007556 - sensitive to diethylstilbestrol

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Genotypes:

FYPO:0007555 - sensitive to econazole

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Genotypes:

FYPO:0000087 - sensitive to hydrogen peroxide

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Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

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Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

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Genotypes:

FYPO:0003358 - sensitive to miconazole

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Genotypes:

FYPO:0001214 - sensitive to potassium chloride

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Genotypes:

FYPO:0001207 - sensitive to raffinose

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Genotypes:

FYPO:0000111 - sensitive to rapamycin

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Genotypes:

FYPO:0002328 - sensitive to terbinafine

References:

Genotypes:

FYPO:0007554 - sensitive to tolnaftate

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Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000070 - gene structure updated

References:

Protein features

IDNameInterPro nameDB name
PF00439BromodomainBromodomainPfam
PF07524Bromo_TPBTPPfam
cd05510Bromo_SPT7_likeCDD
cd22927HFD_SPT7CDD
PS00633BROMODOMAIN_1Bromodomain_CSPROSITE patterns
PS50014BROMODOMAIN_2BromodomainPROSITE profiles
SM00297BROMOBromodomainSMART
SM00576BTPBTPSMART
PR00503BROMODOMAINBromodomainPRINTS
G3DSA:1.20.920.10:FF:000032CATH-FunFam
G3DSA:1.10.20.10Histone-foldCATH-Gene3D
G3DSA:1.20.920.10Bromodomain-like_sfCATH-Gene3D
SSF47370Bromodomain-like_sfSUPERFAMILY
PTHR47343Spt7PANTHER
CoilCOILS
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder
mobidb-lite-Negative-Polyelectrolytedisorder_predictionMobiDB-Negative-Polyelectrolyte
mobidb-lite-Polardisorder_predictionMobiDB-Polar
mobidb-lite-Polyampholytedisorder_predictionMobiDB-Polyampholyte

Orthologs

References / Literature

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:29079657 - TORC1 and TORC2 converge to regulate the SAGA co-activator in response to nutrient availability.
Laboucarié T et al. EMBO Rep 2017 Dec;18(12):2197-2218
PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:21642955 - Tra1 has specific regulatory roles, rather than global functions, within the SAGA co-activator complex.
Helmlinger D et al. EMBO J 2011 Jun 03;30(14):2843-52
PMID:19056896 - The S. pombe SAGA complex controls the switch from proliferation to sexual differentiation through the opposing roles of its subunits Gcn5 and Spt8.
Helmlinger D et al. Genes Dev 2008 Nov 15;22(22):3184-95
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:22540037 - Predicting the fission yeast protein interaction network.
Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:35157728 - TOR complex 2 contributes to regulation of gene expression via inhibiting Gcn5 recruitment to subtelomeric and DNA replication stress genes.
Cohen A et al. PLoS Genet 2022 Feb;18(2):e1010061
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.
Køhler JB et al. Nat Commun 2015 Nov 05;6:8827
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:25015293 - Septin ring assembly is regulated by Spt20, a structural subunit of the SAGA complex.
Lei B et al. J Cell Sci 2014 Sep 15;127(Pt 18):4024-36
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:26443059 - Sgf73, a subunit of SAGA complex, is required for the assembly of RITS complex in fission yeast.
Deng X et al. Sci Rep 2015 Oct 07;5:14707
PMID:31748520 - Chaperone-mediated ordered assembly of the SAGA and NuA4 transcription co-activator complexes in yeast.
Elías-Villalobos A et al. Nat Commun 2019 Nov 20;10(1):5237
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:21270388 - Augmented annotation of the Schizosaccharomyces pombe genome reveals additional genes required for growth and viability.
Bitton DA et al. Genetics 2011 Apr;187(4):1207-17
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.
Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85
PMID:35286199 - Mitotic spindle formation in the absence of Polo kinase.
Kim J et al. Proc Natl Acad Sci U S A 2022 Mar 22;119(12):e2114429119
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.
Lee J et al. Nat Commun 2017 Feb 20;8:14527
PMID:18257517 - Phosphoproteome analysis of fission yeast.
Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97
PMID:23950735 - Global analysis of fission yeast mating genes reveals new autophagy factors.
Sun LL et al. PLoS Genet 2013;9(8):e1003715
PMID:31969703 - Structure of the transcription coactivator SAGA.
Wang H et al. Nature 2020 Jan;577(7792):717-720
PMID:33223513 - Systematic Target Screening Revealed That Tif302 Could Be an Off-Target of the Antifungal Terbinafine in Fission Yeast.
Lee S et al. Biomol Ther (Seoul) 2021 Mar 01;29(2):234-247
PMID:30573453 - Anti-silencing factor Epe1 associates with SAGA to regulate transcription within heterochromatin.
Bao K et al. Genes Dev 2019 Jan 01;33(1-2):116-126