protein coding gene - grx4 (SPBC26H8.06) - CIA machinery monothiol glutaredoxin Grx4

Gene summary

Standard name

grx4

Systematic ID

SPBC26H8.06

Product

CIA machinery monothiol glutaredoxin Grx4

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

O74790

ORFeome ID

08/08H06

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 3957384..3958479 forward strand

Annotation

Protein features

Orthologs

• GLRX3 (HGNC:15987) Homo sapiens
• grx4 (SJAG_00822) Schizosaccharomyces japonicus
• GRX3 (YDR098C) Saccharomyces cerevisiae
• GRX4 (YER174C) Saccharomyces cerevisiae

References / Literature

PMID:21421748 - Grx4 monothiol glutaredoxin is required for iron limitation-dependent inhibition of Fep1.

Jbel M et al. Eukaryot Cell 2011 May;10(5):629-45

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:23695164 - Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.

Das J et al. Sci Signal 2013 May 21;6(276):ra38

PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Lee J et al. Nat Commun 2017 Feb 20;8:14527

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:16175211 - Stress-dependent regulation of a monothiol glutaredoxin gene from Schizosaccharomyces pombe.

Kim HG et al. Can J Microbiol 2005 Jul;51(7):613-20

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:28725905 - Schizosaccharomyces pombe Grx4 regulates the transcriptional repressor Php4 via [2Fe-2S] cluster binding.

Dlouhy AC et al. Metallomics 2017 Aug 16;9(8):1096-1105

PMID:25806539 - A cascade of iron-containing proteins governs the genetic iron starvation response to promote iron uptake and inhibit iron storage in fission yeast.

Encinar del Dedo J et al. PLoS Genet 2015 Mar;11(3):e1005106

PMID:21531205 - Multi-domain CGFS-type glutaredoxin Grx4 regulates iron homeostasis via direct interaction with a repressor Fep1 in fission yeast.

Kim KD et al. Biochem Biophys Res Commun 2011 May 20;408(4):609-14

PMID:24897379 - Fra2 is a co-regulator of Fep1 inhibition in response to iron starvation.

Jacques JF et al. PLoS One 2014;9(6):e98959

PMID:36568394 - Schizosaccharomyces pombe Grx4, Fep1, and Php4: In silico analysis and expression response to different iron concentrations.

Ebrahim A et al. Front Genet 2022;13:1069068

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.

Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101

PMID:23115244 - Cells lacking pfh1, a fission yeast homolog of mammalian frataxin protein, display constitutive activation of the iron starvation response.

Gabrielli N et al. J Biol Chem 2012 Dec 14;287(51):43042-51

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.

Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31

PMID:30355493 - Expanded Interactome of the Intrinsically Disordered Protein Dss1.

Schenstrøm SM et al. Cell Rep 2018 Oct 23;25(4):862-870

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:15796926 - Localization and function of three monothiol glutaredoxins in Schizosaccharomyces pombe.

Chung WH et al. Biochem Biophys Res Commun 2005 May 06;330(2):604-10

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:19502236 - Both Php4 function and subcellular localization are regulated by iron via a multistep mechanism involving the glutaredoxin Grx4 and the exportin Crm1.

Mercier A et al. J Biol Chem 2009 Jul 24;284(30):20249-62

PMID:33064911 - Genes affecting the extension of chronological lifespan in Schizosaccharomyces pombe (fission yeast).

Ohtsuka H et al. Mol Microbiol 2021 Apr;115(4):623-642

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:18182845 - Expression, characterization and regulation of a Saccharomyces cerevisiae monothiol glutaredoxin (Grx6) gene in Schizosaccharomyces pombe.

Lee JH et al. Mol Cells 2007 Dec 31;24(3):316-22

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:22523368 - The monothiol glutaredoxin Grx4 exerts an iron-dependent inhibitory effect on Php4 function.

Vachon P et al. Eukaryot Cell 2012 Jun;11(6):806-19

PMID:37923140 - Iron homeostasis proteins Grx4 and Fra2 control activity of the Schizosaccharomyces pombe iron repressor Fep1 by facilitating [2Fe-2S] cluster removal.

Hati D et al. J Biol Chem 2023 Nov 03;299(12):105419