PomBase home

protein coding gene - mmm1 (SPBC27B12.01c) - ERMES complex subunit, membrane tether and lipid transfer protein Mmm1

Gene summary

Standard name
mmm1
Systematic ID
SPBC27B12.01c
Product
ERMES complex subunit, membrane tether and lipid transfer protein Mmm1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPBC30B4.09c
UniProt ID
O74368
ORFeome ID
18/18B07
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 1320982..1323307 reverse strand

Annotation

GO biological process

GO:0015917 - aminophospholipid transport

References:

GO:0120010 - intermembrane phospholipid transfer

References:

GO:0007006 - mitochondrial membrane organization

References:

GO cellular component

GO:0005737 - cytoplasm

References:

GO:0005783 - endoplasmic reticulum

References:

GO:0032865 - ERMES complex

References:

GO molecular function

GO:0008289 - lipid binding

References:

GO:0140474 - mitochondrion-endoplasmic reticulum membrane tether activity

References:

GO:0120014 - phospholipid transfer activity

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

Protein sequence feature

SO:0001812 - transmembrane_helix

References:

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002107 - inviable stubby vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000070 - gene structure updated

References:

Protein features

IDNameInterPro nameDB name
PF10296MMM1MMM1_domPfam
cd21671SMP_Mmm1CDD
PS51847SMPSMP_LBDPROSITE profiles
PTHR13466PANTHER
Transmembrane alpha helixDeepTMHMM
MF_03103Mmm1Mmm1HAMAP
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder
mobidb-lite-Polardisorder_predictionMobiDB-Polar

Orthologs

References / Literature

PMID:33483504 - Emr1 regulates the number of foci of the endoplasmic reticulum-mitochondria encounter structure complex.
Rasul F et al. Nat Commun 2021 Jan 22;12(1):521
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:30824696 - Systematic analysis reveals the prevalence and principles of bypassable gene essentiality.
Li J et al. Nat Commun 2019 Mar 01;10(1):1002
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PANTHER:PTHR13466 - Unknown title
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
Paulo JA et al. J Proteomics 2020 Jan 06;210:103531
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:29279306 - Structure-function insights into direct lipid transfer between membranes by Mmm1-Mdm12 of ERMES.
Kawano S et al. J Cell Biol 2018 Mar 05;217(3):959-974