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protein coding gene - tom40 (SPBC27B12.13) - mitochondrial TOM complex translocase subunit Tom40

Gene summary

Standard name
tom40
Systematic ID
SPBC27B12.13
Product
mitochondrial TOM complex translocase subunit Tom40
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPBC8D2.22
UniProt ID
O13656
ORFeome ID
41/41H03
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 1356187..1357927 forward strand

Annotation

GO biological process

GO:7770063 - beta barrel protein insertion into mitochondrial outer membrane

References:

GO:0045041 - protein import into mitochondrial intermembrane space

References:

GO:0030150 - protein import into mitochondrial matrix

References:

GO:7770061 - TOM-TIM22-mediated mitochondrial inner membrane protein insertion

References:

GO:7770060 - TOM-TIM23-SORT-mediated protein insertion into the mitochondrial inner membrane

References:

GO cellular component

GO:0005739 - mitochondrion

References:

GO:0140596 - TOM complex

References:

GO molecular function

GO:0008320 - transmembrane protein transporter activity

References:

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0003412 - decreased chromatin silencing at centromere outer repeat

References:

Genotypes:

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF01459Porin_3Porin_Euk/Tom40Pfam
cd07305Porin3_Tom40Tom40CDD
G3DSA:2.40.160.10:FF:000009CATH-FunFam
G3DSA:2.40.160.10Porin_dom_sfCATH-Gene3D
PTHR10802Tom40PANTHER
TIGR009893a0801s07tom40Tom40_fungiNCBIFAM

Orthologs

References / Literature

PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:32101745 - Dense Transposon Integration Reveals Essential Cleavage and Polyadenylation Factors Promote Heterochromatin Formation.
Lee SY et al. Cell Rep 2020 Feb 25;30(8):2686-2698.e8
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
GO_REF:0000033 - Annotation inferences using phylogenetic trees