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protein coding gene - cbp4 (SPBC27B12.14) - mitochondrial respiratory chain complex III assembly protein Cbp4

Gene summary

Standard name
cbp4
Systematic ID
SPBC27B12.14
Product
mitochondrial respiratory chain complex III assembly protein Cbp4
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9USV6
ORFeome ID
31/31E01
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 1348285..1349882 forward strand

Annotation

Disease association

MONDO:0014496 - mitochondrial complex III deficiency nuclear type 9

References:

GO biological process

GO:0034551 - mitochondrial respiratory chain complex III assembly

References:

GO:0006457 - protein folding

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GO cellular component

GO:0005743 - mitochondrial inner membrane

References:

GO:0005739 - mitochondrion

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GO molecular function

GO:0044183 - protein folding chaperone

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Protein sequence feature

SO:0000418 - signal_peptide

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0009073 - decreased cell population growth on lysine nitrogen source

References:

Genotypes:

FYPO:0000636 - increased cell population growth rate

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

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Genotypes:

FYPO:0001501 - sensitive to brefeldin A

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Genotypes:

FYPO:0000096 - sensitive to cadmium

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Genotypes:

FYPO:0009069 - sensitive to ciclopirox olamine

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Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0003656 - sensitive to vanadate

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF07960CBP4Cbp4Pfam
PTHR28202Cbp4PANTHER
Transmembrane alpha helixDeepTMHMM
Signal PeptideSignal-Peptide-DeepTMHMM

Orthologs

References / Literature

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
GO_REF:0000051 - S. pombe keyword mapping
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:25008109 - A mutation in the human CBP4 ortholog UQCC3 impairs complex III assembly, activity and cytochrome b stability.
Wanschers BF et al. Hum Mol Genet 2014 Dec 01;23(23):6356-65
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
GO_REF:0000108 - Automatic assignment of GO terms using logical inference, based on on inter-ontology links.
PMID:25452419 - Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.
Sideri T et al. G3 (Bethesda) 2014 Dec 01;5(1):145-55
PMID:30355493 - Expanded Interactome of the Intrinsically Disordered Protein Dss1.
Schenstrøm SM et al. Cell Rep 2018 Oct 23;25(4):862-870