protein coding gene - rga4 (SPBC28E12.03) - RhoGAP Rga4

Gene summary

Standard name

rga4

Systematic ID

SPBC28E12.03

Product

RhoGAP Rga4

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

O74360

ORFeome ID

30/30B03

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 1839416..1843187 forward strand

Annotation

Protein features

Orthologs

• CHN1 (HGNC:1943) Homo sapiens
• CHN2 (HGNC:1944) Homo sapiens
• rga4 (SJAG_04522) Schizosaccharomyces japonicus
• RGA2 (YDR379W) Saccharomyces cerevisiae
• RGA1 (YOR127W) Saccharomyces cerevisiae

References / Literature

PMID:27168121 - Discovery of genes involved in mitosis, cell division, cell wall integrity and chromosome segregation through construction of Schizosaccharomyces pombe deletion strains.

Chen JS et al. Yeast 2016 Sep;33(9):507-17

PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.

Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85

PMID:21849474 - Spatial control of Cdc42 activation determines cell width in fission yeast.

Kelly FD et al. Mol Biol Cell 2011 Oct;22(20):3801-11

PMID:30318352 - A Positive Feedback between Growth and Polarity Provides Directional Persistency and Flexibility to the Process of Tip Growth.

Haupt A et al. Curr Biol 2018 Oct 22;28(20):3342-3351.e3

PMID:24147005 - The coordination of cell growth during fission yeast mating requires Ras1-GTP hydrolysis.

Weston C et al. PLoS One 2013;8(10):e77487

PMID:30279276 - Differential GAP requirement for Cdc42-GTP polarization during proliferation and sexual reproduction.

Gallo Castro D et al. J Cell Biol 2018 Dec 03;217(12):4215-4229

PMID:21057634 - Rga4, a Rho-GAP from fission yeast: Finding specificity within promiscuity.

Cansado J et al. Commun Integr Biol 2010 Sep;3(5):436-9

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PMID:34523683 - Cdc42 reactivation at growth sites is regulated by local cell-cycle-dependent loss of its GTPase-activating protein Rga4 in fission yeast.

Rich-Robinson J et al. J Cell Sci 2021 Oct 01;134(19)

PMID:19646873 - The conserved NDR kinase Orb6 controls polarized cell growth by spatial regulation of the small GTPase Cdc42.

Das M et al. Curr Biol 2009 Aug 11;19(15):1314-9

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:17377067 - Regulation of cell diameter, For3p localization, and cell symmetry by fission yeast Rho-GAP Rga4p.

Das M et al. Mol Biol Cell 2007 Jun;18(6):2090-101

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:30639107 - Reprogramming Cdr2-Dependent Geometry-Based Cell Size Control in Fission Yeast.

Facchetti G et al. Curr Biol 2019 Jan 21;29(2):350-358.e4

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:26960792 - Rga6 is a Fission Yeast Rho GAP Involved in Cdc42 Regulation of Polarized Growth.

Revilla-Guarinos MT et al. Mol Biol Cell 2016 Mar 09;27(9):1524-35

PMID:20870879 - Reorganization of the growth pattern of Schizosaccharomyces pombe in invasive filament formation.

Dodgson J et al. Eukaryot Cell 2010 Nov;9(11):1788-97

PMID:27984725 - CDK Substrate Phosphorylation and Ordering the Cell Cycle.

Swaffer MP et al. Cell 2016 Dec 15;167(7):1750-1761.e16

PMID:18257517 - Phosphoproteome analysis of fission yeast.

Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97

PMID:18328707 - Pom1 DYRK regulates localization of the Rga4 GAP to ensure bipolar activation of Cdc42 in fission yeast.

Tatebe H et al. Curr Biol 2008 Mar 11;18(5):322-30

PMID:23615447 - Compartmentalized nodes control mitotic entry signaling in fission yeast.

Deng L et al. Mol Biol Cell 2013 Jun;24(12):1872-81

PMID:28947618 - Sde2 is an intron-specific pre-mRNA splicing regulator activated by ubiquitin-like processing.

Thakran P et al. EMBO J 2018 Jan 04;37(1):89-101

PMID:20164182 - Rga4 modulates the activity of the fission yeast cell integrity MAPK pathway by acting as a Rho2 GTPase-activating protein.

Soto T et al. J Biol Chem 2010 Apr 09;285(15):11516-25

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:39012625 - Arp2/3-dependent endocytosis ensures Cdc42 oscillations by removing Pak1-mediated negative feedback.

Harrell MA et al. J Cell Biol 2024 Sep 02;223(10)

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:11737264 - Characterization of GTPase-activating proteins for the function of the Rho-family small GTPases in the fission yeast Schizosaccharomyces pombe.

Nakano K et al. Genes Cells 2001 Dec;6(12):1031-42

PMID:39333500 - Cdc42 mobility and membrane flows regulate fission yeast cell shape and survival.

Rutkowski DM et al. Nat Commun 2024 Sep 27;15(1):8363

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:21340088 - Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.

Arita Y et al. Mol Biosyst 2011 May;7(5):1463-72

PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.

Rallis C et al. Sci Rep 2017 Mar 10;7:44257

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:26246599 - Phosphorylation-dependent inhibition of Cdc42 GEF Gef1 by 14-3-3 protein Rad24 spatially regulates Cdc42 GTPase activity and oscillatory dynamics during cell morphogenesis.

Das M et al. Mol Biol Cell 2015 Oct 01;26(19):3520-34

PMID:24146635 - Hsp70-Hsp40 chaperone complex functions in controlling polarized growth by repressing Hsf1-driven heat stress-associated transcription.

Vjestica A et al. PLoS Genet 2013;9(10):e1003886

PMID:29930085 - Local and global Cdc42 guanine nucleotide exchange factors for fission yeast cell polarity are coordinated by microtubules and the Tea1-Tea4-Pom1 axis.

Tay YD et al. J Cell Sci 2018 Jul 19;131(14)

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160

PMID:24554432 - The Tea4-PP1 landmark promotes local growth by dual Cdc42 GEF recruitment and GAP exclusion.

Kokkoris K et al. J Cell Sci 2014 May 01;127(Pt 9):2005-16

PMID:34382996 - Ultrastructural plasma membrane asymmetries in tension and curvature promote yeast cell fusion.

Muriel O et al. J Cell Biol 2021 Oct 04;220(10)

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323