protein coding gene - cwf7 (SPBC28F2.04c) - Prp19 complex subunit Cwf7

Gene summary

Standard name

cwf7

Systematic ID

SPBC28F2.04c

Product

Prp19 complex subunit Cwf7

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

spf27

UniProt ID

Q9USV3

ORFeome ID

42/42D04

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 1577407..1578069 reverse strand

Annotation

Protein features

Orthologs

• BCAS2 (HGNC:975) Homo sapiens
• cwf7 (SJAG_03711) Schizosaccharomyces japonicus
• SNT309 (YPR101W) Saccharomyces cerevisiae

References / Literature

PMID:15755920 - Dim1p is required for efficient splicing and export of mRNA encoding lid1p, a component of the fission yeast anaphase-promoting complex.

Carnahan RH et al. Eukaryot Cell 2005 Mar;4(3):577-87

PMID:10409726 - Myb-related fission yeast cdc5p is a component of a 40S snRNP-containing complex and is essential for pre-mRNA splicing.

McDonald WH et al. Mol Cell Biol 1999 Aug;19(8):5352-62

PMID:11884590 - Proteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs.

Ohi MD et al. Mol Cell Biol 2002 Apr;22(7):2011-24

PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.

Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7

PMID:39833470 - Structures of aberrant spliceosome intermediates on their way to disassembly.

Soni K et al. Nat Struct Mol Biol 2025 Jan 20;

PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.

Køhler JB et al. Nat Commun 2015 Nov 05;6:8827

PMID:28446597 - The histone variant H2A.Z promotes splicing of weak introns.

Nissen KE et al. Genes Dev 2017 Apr 01;31(7):688-701

PMID:24442611 - Endogenous U2·U5·U6 snRNA complexes in S. pombe are intron lariat spliceosomes.

Chen W et al. RNA 2014 Mar;20(3):308-20

PMID:21386897 - Systematic two-hybrid and comparative proteomic analyses reveal novel yeast pre-mRNA splicing factors connected to Prp19.

Ren L et al. PLoS One 2011 Feb 28;6(2):e16719

PMID:36361590 - Defining the Functional Interactome of Spliceosome-Associated G-Patch Protein Gpl1 in the Fission Yeast Schizosaccharomyces pombe .

Selicky T et al. Int J Mol Sci 2022 Oct 24;23(21)

PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.

Egan ED et al. RNA 2014 Jun;20(6):867-81

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:28947618 - Sde2 is an intron-specific pre-mRNA splicing regulator activated by ubiquitin-like processing.

Thakran P et al. EMBO J 2018 Jan 04;37(1):89-101

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:25274039 - A systematic genetic screen identifies new factors influencing centromeric heterochromatin integrity in fission yeast.

Bayne EH et al. Genome Biol 2014;15(10):481

PMID:31474649 - Identification of 15 New Bypassable Essential Genes of Fission Yeast.

Takeda A et al. Cell Struct Funct 2019 Sep 27;44(2):113-119

PMID:31219728 - Identification of proteins associated with splicing factors Ntr1, Ntr2, Brr2 and Gpl1 in the fission yeast Schizosaccharomyces pombe .

Cipakova I et al. Cell Cycle 2019 Jul;18(14):1532-1536

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:24874881 - The proper splicing of RNAi factors is critical for pericentric heterochromatin assembly in fission yeast.

Kallgren SP et al. PLoS Genet 2014;10(5):e1004334

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:24014766 - Structural and functional characterization of the N terminus of Schizosaccharomyces pombe Cwf10.

Livesay SB et al. Eukaryot Cell 2013 Nov;12(11):1472-89

PMID:12088152 - Characterization of interactions among the Cef1p-Prp19p-associated splicing complex.

Ohi MD et al. RNA 2002 Jun;8(6):798-815

PMID:26292707 - Structure of a yeast spliceosome at 3.6-angstrom resolution.

Yan C et al. Science 2015 Sep 11;349(6253):1182-91

PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41