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protein coding gene - mdm12 (SPBC28F2.06c) - ERMES complex subunit, membrane tether and lipid transfer protein Mdm12

Gene summary

Standard name
mdm12
Systematic ID
SPBC28F2.06c
Product
ERMES complex subunit, membrane tether and lipid transfer protein Mdm12
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q92377
ORFeome ID
31/31H11
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 1579042..1580258 reverse strand

Annotation

GO biological process

GO:0120010 - intermembrane phospholipid transfer

References:

GO:0007006 - mitochondrial membrane organization

References:

GO:1990456 - mitochondrion-endoplasmic reticulum membrane tethering

References:

GO cellular component

GO:0032865 - ERMES complex

References:

GO molecular function

GO:0008289 - lipid binding

References:

GO:0140474 - mitochondrion-endoplasmic reticulum membrane tether activity

References:

GO:0120014 - phospholipid transfer activity

References:

GO:0005515 - protein binding

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011063 - conserved in fungi only

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF26544Mdm12Mdm12PFAM
cd21672SMP_Mdm12CDD
PS51847SMPSMP_LBDPROSITE_PROFILES
PTHR28204MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 12Mdm12PANTHER
MF_03104Mdm12Mdm12HAMAP
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder

Orthologs

References / Literature

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:33483504 - Emr1 regulates the number of foci of the endoplasmic reticulum-mitochondria encounter structure complex.
Rasul F et al. Nat Commun 2021 Jan 22;12(1):521
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:29279306 - Structure-function insights into direct lipid transfer between membranes by Mmm1-Mdm12 of ERMES.
Kawano S et al. J Cell Biol 2018 Mar 05;217(3):959-974
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:9024686 - Mdm12p, a component required for mitochondrial inheritance that is conserved between budding and fission yeast.
Berger KH et al. J Cell Biol 1997 Feb 10;136(3):545-53
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:30824696 - Systematic analysis reveals the prevalence and principles of bypassable gene essentiality.
Li J et al. Nat Commun 2019 Mar 01;10(1):1002
GO_REF:0000002 - Comments
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference