protein coding gene - sfr1 (SPBC28F2.07) - DNA recombination mediator Sfr1

Gene summary

Standard name

sfr1

Systematic ID

SPBC28F2.07

Product

DNA recombination mediator Sfr1

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

dds20, mug13

UniProt ID

Q9USV1

ORFeome ID

12/12D03

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 1580456..1581880 forward strand

Annotation

Protein features

Orthologs

• SFR1 (HGNC:29574) Homo sapiens
• sfr1 (SJAG_01708) Schizosaccharomyces japonicus
• MEI5 (YPL121C) Saccharomyces cerevisiae

References / Literature

PMID:25864229 - Mutants of Schizosaccharomyces pombe which sporulate in the haploid state.

Lino Y et al. Mol Gen Genet 1985;198(3):416-21

PMID:18769921 - Genetic analysis reveals different roles of Schizosaccharomyces pombe sfr1/dds20 in meiotic and mitotic DNA recombination and repair.

Khasanov FK et al. Curr Genet 2008 Oct;54(4):197-211

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:16080597 - [The dds20+ gene controls a novel Rad51Sp-dependent pathway of recombinational repair in Schizosaccharomyces pombe].

Salakhova AF et al. Genetika 2005 Jun;41(6):736-45

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PMID:30297419 - Swi5-Sfr1 stimulates Rad51 recombinase filament assembly by modulating Rad51 dissociation.

Lu CH et al. Proc Natl Acad Sci U S A 2018 Oct 23;115(43):E10059-E10068

PMID:24186976 - Dual regulation of Dmc1-driven DNA strand exchange by Swi5-Sfr1 activation and Rad22 inhibition.

Murayama Y et al. Genes Dev 2013 Nov 01;27(21):2299-304

PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.

Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85

PMID:27984725 - CDK Substrate Phosphorylation and Ordering the Cell Cycle.

Swaffer MP et al. Cell 2016 Dec 15;167(7):1750-1761.e16

PMID:18231579 - The CDK-activating kinase (CAK) Csk1 is required for normal levels of homologous recombination and resistance to DNA damage in fission yeast.

Gerber HB et al. PLoS One 2008 Jan 30;3(1):e1492

PMID:16615890 - Meiotic proteins bqt1 and bqt2 tether telomeres to form the bouquet arrangement of chromosomes.

Chikashige Y et al. Cell 2006 Apr 07;125(1):59-69

PMID:23628481 - A proteome-wide visual screen identifies fission yeast proteins localizing to DNA double-strand breaks.

Yu Y et al. DNA Repair (Amst) 2013 Jun 01;12(6):433-43

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:25165823 - Multiple regulation of Rad51-mediated homologous recombination by fission yeast Fbh1.

Tsutsui Y et al. PLoS Genet 2014 Aug;10(8):e1004542

PMID:20625380 - A genome-wide screen for Schizosaccharomyces pombe deletion mutants that affect telomere length.

Liu NN et al. Cell Res 2010 Aug;20(8):963-5

PMID:19037101 - Mus81, Rhp51(Rad51), and Rqh1 form an epistatic pathway required for the S-phase DNA damage checkpoint.

Willis N et al. Mol Biol Cell 2009 Feb;20(3):819-33

PMID:21183410 - Schizosaccharomyces pombe Mms1 channels repair of perturbed replication into Rhp51 independent homologous recombination.

Vejrup-Hansen R et al. DNA Repair (Amst) 2011 Mar 07;10(3):283-95

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:22405003 - Mechanistic insights into the activation of Rad51-mediated strand exchange from the structure of a recombination activator, the Swi5-Sfr1 complex.

Kuwabara N et al. Structure 2012 Mar 07;20(3):440-9

PMID:14663140 - Two different Swi5-containing protein complexes are involved in mating-type switching and recombination repair in fission yeast.

Akamatsu Y et al. Proc Natl Acad Sci U S A 2003 Dec 23;100(26):15770-5

PMID:25414342 - Rad51/Dmc1 paralogs and mediators oppose DNA helicases to limit hybrid DNA formation and promote crossovers during meiotic recombination.

Lorenz A et al. Nucleic Acids Res 2014 Dec 16;42(22):13723-35

PMID:29323270 - Two three-strand intermediates are processed during Rad51-driven DNA strand exchange.

Ito K et al. Nat Struct Mol Biol 2018 Jan;25(1):29-36

PMID:31064814 - Proximity-dependent biotinylation mediated by TurboID to identify protein-protein interaction networks in yeast.

Larochelle M et al. J Cell Sci 2019 May 31;132(11)

PMID:20823543 - Expression, purification and crystallization of Swi5 and the Swi5-Sfr1 complex from fission yeast.

Kuwabara N et al. Acta Crystallogr Sect F Struct Biol Cryst Commun 2010 Sep 01;66(Pt 9):1124-6

PMID:23828040 - Involvement of Schizosaccharomyces pombe rrp1+ and rrp2+ in the Srs2- and Swi5/Sfr1-dependent pathway in response to DNA damage and replication inhibition.

Dziadkowiec D et al. Nucleic Acids Res 2013 Sep;41(17):8196-209

PMID:23695164 - Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.

Das J et al. Sci Signal 2013 May 21;6(276):ra38

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:25552606 - Identification of new players in cell division, DNA damage response, and morphogenesis through construction of Schizosaccharomyces pombe deletion strains.

Chen JS et al. G3 (Bethesda) 2014 Dec 31;5(3):361-70

PMID:23324799 - Characterisation of an intrinsically disordered protein complex of Swi5-Sfr1 by ion mobility mass spectrometry and small-angle X-ray scattering.

Saikusa K et al. Analyst 2013 Mar 07;138(5):1441-9

PMID:16303567 - A large-scale screen in S. pombe identifies seven novel genes required for critical meiotic events.

Martín-Castellanos C et al. Curr Biol 2005 Nov 22;15(22):2056-62

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.

Mata J et al. Nat Genet 2002 Sep;32(1):143-7

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:22723423 - The fission yeast FANCM ortholog directs non-crossover recombination during meiosis.

Lorenz A et al. Science 2012 Jun 22;336(6088):1585-8

PMID:32414915 - Two auxiliary factors promote Dmc1-driven DNA strand exchange via stepwise mechanisms.

Tsubouchi H et al. Proc Natl Acad Sci U S A 2020 Jun 02;117(22):12062-12070

PMID:30824696 - Systematic analysis reveals the prevalence and principles of bypassable gene essentiality.

Li J et al. Nat Commun 2019 Mar 01;10(1):1002

PMID:18416603 - Reconstitution of DNA strand exchange mediated by Rhp51 recombinase and two mediators.

Kurokawa Y et al. PLoS Biol 2008 Apr 15;6(4):e88

PMID:32204793 - Cooperative interactions facilitate stimulation of Rad51 by the Swi5-Sfr1 auxiliary factor complex.

Argunhan B et al. Elife 2020 Mar 24;9

PMID:29898918 - Mutations that prevent methylation of cohesin render sensitivity to DNA damage in S. pombe .

Sanyal S et al. J Cell Sci 2018 Jul 06;131(13)

PMID:20065069 - The fission yeast Rad32(Mre11)-Rad50-Nbs1 complex acts both upstream and downstream of checkpoint signaling in the S-phase DNA damage checkpoint.

Willis N et al. Genetics 2010 Apr;184(4):887-97

PMID:34208949 - Mapping and Analysis of Swi5 and Sfr1 Phosphorylation Sites.

Sevcovicova A et al. Genes (Basel) 2021 Jun 30;12(7)

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:17304215 - Fission yeast Swi5/Sfr1 and Rhp55/Rhp57 differentially regulate Rhp51-dependent recombination outcomes.

Akamatsu Y et al. EMBO J 2007 Mar 07;26(5):1352-62

PMID:39174851 - CDK phosphorylation of Sfr1 downregulates Rad51 function in late-meiotic homolog invasions.

Palacios-Blanco I et al. EMBO J 2024 Aug 22;

PMID:19185548 - The role of novel genes rrp1(+) and rrp2(+) in the repair of DNA damage in Schizosaccharomyces pombe.

Dziadkowiec D et al. DNA Repair (Amst) 2009 May 01;8(5):627-36

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:16921379 - The Swi5-Sfr1 complex stimulates Rhp51/Rad51- and Dmc1-mediated DNA strand exchange in vitro.

Haruta N et al. Nat Struct Mol Biol 2006 Sep;13(9):823-30

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:27304859 - Dbl2 Regulates Rad51 and DNA Joint Molecule Metabolism to Ensure Proper Meiotic Chromosome Segregation.

Polakova S et al. PLoS Genet 2016 Jun;12(6):e1006102

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:29550859 - Genetic interactions between the chromosome axis-associated protein Hop1 and homologous recombination determinants in Schizosaccharomyces pombe.

Brown SD et al. Curr Genet 2018 Oct;64(5):1089-1104

PMID:39340300 - The Swi5-Sfr1 complex regulates Dmc1- and Rad51-driven DNA strand exchange proceeding through two distinct three-stranded intermediates by different mechanisms.

Ito K et al. Nucleic Acids Res 2024 Sep 28;

PMID:20885790 - Critical functions of Rpa3/Ssb3 in S-phase DNA damage responses in fission yeast.

Cavero S et al. PLoS Genet 2010 Sep 23;6(9):e1001138

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:22033972 - Fission yeast Swi5-Sfr1 protein complex, an activator of Rad51 recombinase, forms an extremely elongated dogleg-shaped structure.

Kokabu Y et al. J Biol Chem 2011 Dec 16;286(50):43569-76

PMID:37330173 - Phosphoregulation of DNA repair via the Rad51 auxiliary factor Swi5-Sfr1.

Liang P et al. J Biol Chem 2023 Aug;299(8):104929

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6