protein coding gene - rpb1 (SPBC28F2.12) - DNA-directed RNA polymerase II complex large subunit Rpb1

Gene summary

Standard name

rpb1

Systematic ID

SPBC28F2.12

Product

DNA-directed RNA polymerase II complex large subunit Rpb1

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

P36594

ORFeome ID

41/41B01

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 1591140..1596744 forward strand

Annotation

Protein features

Orthologs

• POLR2A (HGNC:9187) Homo sapiens
• rpb1 (SJAG_01713) Schizosaccharomyces japonicus
• RPO21 (YDL140C) Saccharomyces cerevisiae

References / Literature

PMID:11839823 - Formation of a carboxy-terminal domain phosphatase (Fcp1)/TFIIF/RNA polymerase II (pol II) complex in Schizosaccharomyces pombe involves direct interaction between Fcp1 and the Rpb4 subunit of pol II.

Kimura M et al. Mol Cell Biol 2002 Mar;22(5):1577-88

PMID:11572939 - Analysis of Schizosaccharomyces pombe mediator reveals a set of essential subunits conserved between yeast and metazoan cells.

Spåhr H et al. Proc Natl Acad Sci U S A 2001 Oct 09;98(21):11985-90

PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41

PMID:33771877 - RNA polymerase backtracking results in the accumulation of fission yeast condensin at active genes.

Rivosecchi J et al. Life Sci Alliance 2021 Jun;4(6)

PMID:9645434 - Alteration of the largest subunit of RNA polymerase II and its effect on chromosome stability in Schizosaccharomyces pombe.

Sugaya K et al. Mol Gen Genet 1998 May;258(3):279-87

PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.

Køhler JB et al. Nat Commun 2015 Nov 05;6:8827

PMID:15620689 - Glyceraldehyde-3-phosphate dehydrogenase and actin associate with RNA polymerase II and interact with its Rpb7 subunit.

Mitsuzawa H et al. FEBS Lett 2005 Jan 03;579(1):48-52

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:15798214 - A novel domain in Set2 mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation.

Kizer KO et al. Mol Cell Biol 2005 Apr;25(8):3305-16

PMID:19458260 - Schizosacharomyces pombe RNA polymerase II at 3.6-A resolution.

Spåhr H et al. Proc Natl Acad Sci U S A 2009 Jun 09;106(23):9185-90

PMID:20231361 - Separable functions of the fission yeast Spt5 carboxyl-terminal domain (CTD) in capping enzyme binding and transcription elongation overlap with those of the RNA polymerase II CTD.

Schneider S et al. Mol Cell Biol 2010 May;30(10):2353-64

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:8557037 - Identification of a cdk-activating kinase in fission yeast.

Buck V et al. EMBO J 1995 Dec 15;14(24):6173-83

PMID:26792892 - Histone H3K36 trimethylation is essential for multiple silencing mechanisms in fission yeast.

Suzuki S et al. Nucleic Acids Res 2016 May 19;44(9):4147-62

PMID:16428435 - Cyclin-dependent kinase 9 (Cdk9) of fission yeast is activated by the CDK-activating kinase Csk1, overlaps functionally with the TFIIH-associated kinase Mcs6, and associates with the mRNA cap methyltransferase Pcm1 in vivo.

Pei Y et al. Mol Cell Biol 2006 Feb;26(3):777-88

PMID:34389684 - Genetic screen for suppression of transcriptional interference identifies a gain-of-function mutation in Pol2 termination factor Seb1.

Schwer B et al. Proc Natl Acad Sci U S A 2021 Aug 17;118(33)

PMID:33711009 - Structure-function analysis of fission yeast cleavage and polyadenylation factor (CPF) subunit Ppn1 and its interactions with Dis2 and Swd22.

Benjamin B et al. PLoS Genet 2021 Mar;17(3):e1009452

PMID:30355493 - Expanded Interactome of the Intrinsically Disordered Protein Dss1.

Schenstrøm SM et al. Cell Rep 2018 Oct 23;25(4):862-870

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:15743411 - Studies of Schizosaccharomyces pombe TFIIE indicate conformational and functional changes in RNA polymerase II at transcription initiation.

Hayashi K et al. Genes Cells 2005 Mar;10(3):207-24

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:17502918 - A cyclin-dependent kinase that promotes cytokinesis through modulating phosphorylation of the carboxy terminal domain of the RNA Pol II Rpb1p sub-unit.

Karagiannis J et al. PLoS One 2007 May 09;2(5):e433

PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.

Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684

PMID:9738888 - Mapping of Rpb3 and Rpb5 contact sites on two large subunits, Rpb1 and Rpb2, of the RNA polymerase II from fission yeast.

Miyao T et al. Mol Gen Genet 1998 Jul;259(1):123-9

PMID:17512405 - RNAi-dependent and -independent RNA turnover mechanisms contribute to heterochromatic gene silencing.

Bühler M et al. Cell 2007 May 18;129(4):707-21

PMID:17339332 - Rct1, a nuclear RNA recognition motif-containing cyclophilin, regulates phosphorylation of the RNA polymerase II C-terminal domain.

Gullerova M et al. Mol Cell Biol 2007 May;27(10):3601-11

PMID:12738880 - TRAP230/ARC240 and TRAP240/ARC250 Mediator subunits are functionally conserved through evolution.

Samuelsen CO et al. Proc Natl Acad Sci U S A 2003 May 27;100(11):6422-7

PMID:26443059 - Sgf73, a subunit of SAGA complex, is required for the assembly of RITS complex in fission yeast.

Deng X et al. Sci Rep 2015 Oct 07;5:14707

PMID:26264592 - RNA polymerase II CTD phospho-sites Ser5 and Ser7 govern phosphate homeostasis in fission yeast.

Schwer B et al. RNA 2015 Oct;21(10):1770-80

PMID:17434129 - S. pombe LSD1 homologs regulate heterochromatin propagation and euchromatic gene transcription.

Lan F et al. Mol Cell 2007 Apr 13;26(1):89-101

PMID:31269446 - CPF Recruitment to Non-canonical Transcription Termination Sites Triggers Heterochromatin Assembly and Gene Silencing.

Vo TV et al. Cell Rep 2019 Jul 02;28(1):267-281.e5

PMID:32101745 - Dense Transposon Integration Reveals Essential Cleavage and Polyadenylation Factors Promote Heterochromatin Formation.

Lee SY et al. Cell Rep 2020 Feb 25;30(8):2686-2698.e8

PMID:28241144 - Mediator structure and rearrangements required for holoenzyme formation.

Tsai KL et al. Nature 2017 Apr 13;544(7649):196-201

PMID:16087749 - Histone H3 K36 methylation is associated with transcription elongation in Schizosaccharomyces pombe.

Morris SA et al. Eukaryot Cell 2005 Aug;4(8):1446-54

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:10648788 - Involvement of multiple subunit-subunit contacts in the assembly of RNA polymerase II.

Kimura M et al. Nucleic Acids Res 2000 Feb 15;28(4):952-9

PMID:21725325 - Coordination of DNA replication and histone modification by the Rik1-Dos2 complex.

Li F et al. Nature 2011 Jul 03;475(7355):244-8

PMID:22540037 - Predicting the fission yeast protein interaction network.

Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67

PMID:30282034 - Elongation/Termination Factor Exchange Mediated by PP1 Phosphatase Orchestrates Transcription Termination.

Kecman T et al. Cell Rep 2018 Oct 02;25(1):259-269.e5

PMID:30355770 - RNA polymerase II CTD interactome with 3' processing and termination factors in fission yeast and its impact on phosphate homeostasis.

Sanchez AM et al. Proc Natl Acad Sci U S A 2018 Nov 06;115(45):E10652-E10661

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:24583182 - A novel method for purification of the endogenously expressed fission yeast Set2 complex.

Suzuki S et al. Protein Expr Purif 2014 May;97:44-9

PMID:12904290 - Characterization of the Schizosaccharomyces pombe Cdk9/Pch1 protein kinase: Spt5 phosphorylation, autophosphorylation, and mutational analysis.

Pei Y et al. J Biol Chem 2003 Oct 31;278(44):43346-56

PMID:28515143 - Cyclin C influences the timing of mitosis in fission yeast.

Banyai G et al. Mol Biol Cell 2017 Jul 01;28(13):1738-1744

PMID:11387325 - The length, phosphorylation state, and primary structure of the RNA polymerase II carboxyl-terminal domain dictate interactions with mRNA capping enzymes.

Pei Y et al. J Biol Chem 2001 Jul 27;276(30):28075-82

PMID:12475973 - Interactions between fission yeast Cdk9, its cyclin partner Pch1, and mRNA capping enzyme Pct1 suggest an elongation checkpoint for mRNA quality control.

Pei Y et al. J Biol Chem 2003 Feb 28;278(9):7180-8

PMID:21340088 - Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.

Arita Y et al. Mol Biosyst 2011 May;7(5):1463-72

PMID:26219431 - Structure of Ctk3, a subunit of the RNA polymerase II CTD kinase complex, reveals a noncanonical CTD-interacting domain fold.

Mühlbacher W et al. Proteins 2015 Oct;83(10):1849-58

PMID:32059768 - Size-Dependent Increase in RNA Polymerase II Initiation Rates Mediates Gene Expression Scaling with Cell Size.

Sun XM et al. Curr Biol 2020 Apr 06;30(7):1217-1230.e7

PMID:9077438 - Molecular assembly of RNA polymerase II from the fission yeast Schizosaccharomyces pombe: subunit-subunit contact network involving Rpb5.

Miyao T et al. Genes Cells 1996 Sep;1(9):843-54

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:18257517 - Phosphoproteome analysis of fission yeast.

Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97

PMID:21931816 - Global gene expression analysis of fission yeast mutants impaired in Ser-2 phosphorylation of the RNA pol II carboxy terminal domain.

Saberianfar R et al. PLoS One 2011;6(9):e24694

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Lee J et al. Nat Commun 2017 Feb 20;8:14527

PMID:9325316 - RNA polymerase II subunits 2, 3, and 11 form a core subassembly with DNA binding activity.

Kimura M et al. J Biol Chem 1997 Oct 10;272(41):25851-5

PMID:28366642 - Spt5 Plays Vital Roles in the Control of Sense and Antisense Transcription Elongation.

Shetty A et al. Mol Cell 2017 Apr 06;66(1):77-88.e5

PMID:11168400 - Intracellular contents and assembly states of all 12 subunits of the RNA polymerase II in the fission yeast Schizosaccharomyces pombe.

Kimura M et al. Eur J Biochem 2001 Feb;268(3):612-9

PMID:29237752 - Ser7 of RNAPII-CTD facilitates heterochromatin formation by linking ncRNA to RNAi.

Kajitani T et al. Proc Natl Acad Sci U S A 2017 Dec 26;114(52):E11208-E11217

PMID:10625684 - Purification and characterization of RNA polymerase II holoenzyme from Schizosaccharomyces pombe.

Spåhr H et al. J Biol Chem 2000 Jan 14;275(2):1351-6

PMID:31276588 - Inositol pyrophosphates impact phosphate homeostasis via modulation of RNA 3' processing and transcription termination.

Sanchez AM et al. Nucleic Acids Res 2019 Sep 19;47(16):8452-8469

PMID:32496538 - Cdk9 and H2Bub1 signal to Clr6-CII/Rpd3S to suppress aberrant antisense transcription.

Sansó M et al. Nucleic Acids Res 2020 Jul 27;48(13):7154-7168

PMID:24939935 - How an mRNA capping enzyme reads distinct RNA polymerase II and Spt5 CTD phosphorylation codes.

Doamekpor SK et al. Genes Dev 2014 Jun 15;28(12):1323-36

PMID:19026779 - The structure of Fcp1, an essential RNA polymerase II CTD phosphatase.

Ghosh A et al. Mol Cell 2008 Nov 21;32(4):478-90

PMID:32062975 - Phosphoproteomics Reveals Novel Targets and Phosphoprotein Networks in Cell Cycle Mediated by Dsk1 Kinase.

Wu M et al. J Proteome Res 2020 Apr 03;19(4):1776-1787

PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134

PMID:28367989 - The conserved protein Seb1 drives transcription termination by binding RNA polymerase II and nascent RNA.

Wittmann S et al. Nat Commun 2017 Apr 03;8:14861

PMID:35012333 - Cleavage-Polyadenylation Factor Cft1 and SPX Domain Proteins Are Agents of Inositol Pyrophosphate Toxicosis in Fission Yeast.

Schwer B et al. mBio 2022 Feb 22;13(1):e0347621

PMID:38899862 - Suppression of inositol pyrophosphate toxicosis and hyper-repression of the fission yeast PHO regulon by loss-of-function mutations in chromatin remodelers Snf22 and Sol1.

Schwer B et al. mBio 2024 Jun 20;:e0125224

PMID:24013502 - Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries.

Wang J et al. Genes Dev 2013 Sep 01;27(17):1886-902

PMID:11893740 - Interactions between fission yeast mRNA capping enzymes and elongation factor Spt5.

Pei Y et al. J Biol Chem 2002 May 31;277(22):19639-48

PMID:19111658 - HP1 proteins form distinct complexes and mediate heterochromatic gene silencing by nonoverlapping mechanisms.

Motamedi MR et al. Mol Cell 2008 Dec 26;32(6):778-90

PMID:26275777 - Functional interaction of Rpb1 and Spt5 C-terminal domains in co-transcriptional histone modification.

Mbogning J et al. Nucleic Acids Res 2015 Nov 16;43(20):9766-75

PMID:39746995 - DSIF factor Spt5 coordinates transcription, maturation and exoribonucleolysis of RNA polymerase II transcripts.

Kuś K et al. Nat Commun 2025 Jan 02;16(1):10

PMID:28479325 - Size-Dependent Expression of the Mitotic Activator Cdc25 Suggests a Mechanism of Size Control in Fission Yeast.

Keifenheim D et al. Curr Biol 2017 May 22;27(10):1491-1497.e4

PMID:37279920 - A dual, catalytic role for the fission yeast Ccr4-Not complex in gene silencing and heterochromatin spreading.

Challal D et al. Genetics 2023 Aug 09;224(4)

PMID:22144909 - The fission yeast stress-responsive MAPK pathway promotes meiosis via the phosphorylation of Pol II CTD in response to environmental and feedback cues.

Sukegawa Y et al. PLoS Genet 2011 Dec;7(12):e1002387

PMID:22508988 - Separate domains of fission yeast Cdk9 (P-TEFb) are required for capping enzyme recruitment and primed (Ser7-phosphorylated) Rpb1 carboxyl-terminal domain substrate recognition.

St Amour CV et al. Mol Cell Biol 2012 Jul;32(13):2372-83

PMID:36882296 - Duf89 abets lncRNA control of fission yeast phosphate homeostasis via its antagonism of precocious lncRNA transcription termination.

Sanchez AM et al. RNA 2023 Jun;29(6):808-825

PMID:30652128 - Heterochromatin suppresses gross chromosomal rearrangements at centromeres by repressing Tfs1/TFIIS-dependent transcription.

Okita AK et al. Commun Biol 2019;2:17

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:11918671 - Level of the RNA polymerase II in the fission yeast stays constant but phosphorylation of its carboxyl terminal domain varies depending on the phase and rate of cell growth.

Sakurai H et al. Genes Cells 2002 Mar;7(3):273-84

PMID:32499400 - Nutrient-dependent control of RNA polymerase II elongation rate regulates specific gene expression programs by alternative polyadenylation.

Yague-Sanz C et al. Genes Dev 2020 Jul 01;34(13-14):883-897

PMID:20605454 - A gene-specific requirement of RNA polymerase II CTD phosphorylation for sexual differentiation in S. pombe.

Coudreuse D et al. Curr Biol 2010 Jun 22;20(12):1053-64

PMID:29618061 - Histone deacetylation promotes transcriptional silencing at facultative heterochromatin.

Watts BR et al. Nucleic Acids Res 2018 Jun 20;46(11):5426-5440

PMID:34967420 - Genetic screen for suppression of transcriptional interference reveals fission yeast 14-3-3 protein Rad24 as an antagonist of precocious Pol2 transcription termination.

Garg A et al. Nucleic Acids Res 2022 Jan 25;50(2):803-819

PMID:40132111 - A fission yeast CENP-B homologue Abp1 prevents RNAi-mediated heterochromatin formation at ribosomal DNA repeats.

Tsunemine S et al. Genetics 2025 Mar 25;

PMID:17363370 - HULC, a histone H2B ubiquitinating complex, modulates heterochromatin independent of histone methylation in fission yeast.

Zofall M et al. J Biol Chem 2007 May 11;282(19):14065-72

PMID:17289569 - SHREC, an effector complex for heterochromatic transcriptional silencing.

Sugiyama T et al. Cell 2007 Feb 09;128(3):491-504

PMID:27401558 - The Nrd1-like protein Seb1 coordinates cotranscriptional 3' end processing and polyadenylation site selection.

Lemay JF et al. Genes Dev 2016 Jul 01;30(13):1558-72

PMID:24945319 - CPF-associated phosphatase activity opposes condensin-mediated chromosome condensation.

Vanoosthuyse V et al. PLoS Genet 2014 Jun;10(6):e1004415

PMID:28476936 - Genome-wide screen for cell growth regulators in fission yeast.

Weston L et al. J Cell Sci 2017 Jun 15;130(12):2049-2055

PMID:20299449 - A chromodomain switch mediated by histone H3 Lys 4 acetylation regulates heterochromatin assembly.

Xhemalce B et al. Genes Dev 2010 Apr 01;24(7):647-52

PMID:17150956 - Identification and Characterization of a Schizosaccharomyces pombe RNA Polymerase II Elongation Factor with Similarity to the Metazoan Transcription Factor ELL.

Banks CA et al. J Biol Chem 2007 Feb 23;282(8):5761-9

PMID:29899453 - A Cdk9-PP1 switch regulates the elongation-termination transition of RNA polymerase II.

Parua PK et al. Nature 2018 Jun;558(7710):460-464

PMID:24240238 - Elimination of shelterin components bypasses RNAi for pericentric heterochromatin assembly.

Tadeo X et al. Genes Dev 2013 Nov 15;27(22):2489-99

PMID:25691663 - Fission yeast Cdk7 controls gene expression through both its CAK and C-terminal domain kinase activities.

Devos M et al. Mol Cell Biol 2015 May;35(9):1480-90

PMID:15829570 - Impairment of the TFIIH-associated CDK-activating kinase selectively affects cell cycle-regulated gene expression in fission yeast.

Lee KM et al. Mol Biol Cell 2005 Jun;16(6):2734-45

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:23122962 - Cdk11-cyclinL controls the assembly of the RNA polymerase II mediator complex.

Drogat J et al. Cell Rep 2012 Nov 29;2(5):1068-76

PMID:37772819 - Activities, substrate specificity, and genetic interactions of fission yeast Siw14, a cysteinyl-phosphatase-type inositol pyrophosphatase.

Sanchez AM et al. mBio 2023 Sep 29;14(5):e0205623

PMID:33010152 - A genetic screen for suppressors of hyper-repression of the fission yeast PHO regulon by Pol2 CTD mutation T4A implicates inositol 1-pyrophosphates as agonists of precocious lncRNA transcription termination.

Garg A et al. Nucleic Acids Res 2020 Nov 04;48(19):10739-10752

PMID:26098123 - Promoter nucleosome dynamics regulated by signalling through the CTD code.

Materne P et al. Elife 2015 Jun 22;4:e09008

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:29414789 - A long noncoding (lnc)RNA governs expression of the phosphate transporter Pho84 in fission yeast and has cascading effects on the flanking prt lncRNA and pho1 genes.

Garg A et al. J Biol Chem 2018 Mar 23;293(12):4456-4467

PMID:33579781 - Transcriptional profiling of fission yeast RNA polymerase II CTD mutants.

Garg A et al. RNA 2021 Feb 12;27(5):560-70

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:40402811 - Characterization of oncohistone H2B variants in Schizosaccharomyces pombe reveals a key role of H2B monoubiquitination deficiency in genomic instability by altering gene expression.

Lu G et al. FEMS Yeast Res 2025 May 22;

PMID:16762840 - Swi6/HP1 recruits a JmjC domain protein to facilitate transcription of heterochromatic repeats.

Zofall M et al. Mol Cell 2006 Jun 09;22(5):681-92

PMID:19328067 - TFIIH and P-TEFb coordinate transcription with capping enzyme recruitment at specific genes in fission yeast.

Viladevall L et al. Mol Cell 2009 Mar 27;33(6):738-51

PMID:32282918 - Genetic interactions and transcriptomics implicate fission yeast CTD prolyl isomerase Pin1 as an agent of RNA 3' processing and transcription termination that functions via its effects on CTD phosphatase Ssu72.

Sanchez AM et al. Nucleic Acids Res 2020 May 21;48(9):4811-4826

PMID:31353023 - De Novo Heterozygous POLR2A Variants Cause a Neurodevelopmental Syndrome with Profound Infantile-Onset Hypotonia.

Haijes HA et al. Am J Hum Genet 2019 Aug 01;105(2):283-301

PMID:16204182 - RNA Pol II subunit Rpb7 promotes centromeric transcription and RNAi-directed chromatin silencing.

Djupedal I et al. Genes Dev 2005 Oct 01;19(19):2301-6

PMID:30503616 - Centromere DNA Destabilizes H3 Nucleosomes to Promote CENP-A Deposition during the Cell Cycle.

Shukla M et al. Curr Biol 2018 Dec 17;28(24):3924-3936.e4

PMID:19336419 - Cotranscriptional recruitment of the nuclear poly(A)-binding protein Pab2 to nascent transcripts and association with translating mRNPs.

Lemieux C et al. Nucleic Acids Res 2009 Jun;37(10):3418-30

PMID:22771993 - Distinct requirement of RNA polymerase II CTD phosphorylations in budding and fission yeast.

Cassart C et al. Transcription 2012;3(5):231-4

PMID:9642054 - Two large subunits of the fission yeast RNA polymerase II provide platforms for the assembly of small subunits.

Ishiguro A et al. J Mol Biol 1998 Jun 19;279(4):703-12

PMID:25883047 - Genetic and structural analysis of the essential fission yeast RNA polymerase II CTD phosphatase Fcp1.

Schwer B et al. RNA 2015 Jun;21(6):1135-46

PMID:33410907 - The fission yeast Pin1 peptidyl-prolyl isomerase promotes dissociation of Sty1 MAPK from RNA polymerase II and recruits Ssu72 phosphatase to facilitate oxidative stress induced transcription.

Wang YT et al. Nucleic Acids Res 2021 Jan 25;49(2):805-817

PMID:9322754 - Gene organization and protein sequence of the small subunits of Schizosaccharomyces pombe RNA polymerase II.

Sakurai H et al. Gene 1997 Sep 01;196(1-2):165-74

PMID:35970865 - The Mis6 inner kinetochore subcomplex maintains CENP-A nucleosomes against centromeric non-coding transcription during mitosis.

Hirai H et al. Commun Biol 2022 Aug 15;5(1):818

PMID:15182371 - Mediator is required for activated transcription in a Schizosaccharomyces pombe in vitro system.

Tamayo E et al. Eur J Biochem 2004 Jun;271(12):2561-72

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:39747188 - PhpC NF-Y transcription factor infiltrates heterochromatin to generate cryptic intron-containing transcripts crucial for small RNA production.

Srivastav MK et al. Nat Commun 2025 Jan 02;16(1):268

PMID:32546512 - Inactivation of fission yeast Erh1 de-represses pho1 expression: evidence that Erh1 is a negative regulator of prt lncRNA termination.

Schwer B et al. RNA 2020 Oct;26(10):1334-1344

PMID:21892171 - Defects in RNA quality control factors reveal RNAi-independent nucleation of heterochromatin.

Reyes-Turcu FE et al. Nat Struct Mol Biol 2011 Sep 04;18(10):1132-8

PMID:30321377 - Proteomic profiling and functional characterization of post-translational modifications of the fission yeast RNA exosome.

Telekawa C et al. Nucleic Acids Res 2018 Nov 30;46(21):11169-11183

PMID:20622014 - Negative regulation of meiotic gene expression by the nuclear poly(a)-binding protein in fission yeast.

St-André O et al. J Biol Chem 2010 Sep 03;285(36):27859-68

PMID:12455993 - Divergent subunit interactions among fungal mRNA 5'-capping machineries.

Takagi T et al. Eukaryot Cell 2002 Jun;1(3):448-57