protein coding gene - spo5 (SPBC29A10.02) - meiotic RNA-binding protein 1

Gene summary

Standard name

spo5

Systematic ID

SPBC29A10.02

Product

meiotic RNA-binding protein 1

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

mrb1, mug12, SPBC365.18

UniProt ID

Q2L4W6

ORFeome ID

45/45H09

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 2536150..2538254 forward strand

Annotation

Protein features

Orthologs

• RBMS3 (HGNC:13427) Homo sapiens
• RBMS1 (HGNC:9907) Homo sapiens
• RBMS2 (HGNC:9909) Homo sapiens
• spo5 (SJAG_04271) Schizosaccharomyces japonicus

References / Literature

PMID:28765164 - Selective termination of lncRNA transcription promotes heterochromatin silencing and cell differentiation.

Touat-Todeschini L et al. EMBO J 2017 Sep 01;36(17):2626-2641

PMID:22912768 - Rhn1, a nuclear protein, is required for suppression of meiotic mRNAs in mitotically dividing fission yeast.

Sugiyama T et al. PLoS One 2012;7(8):e42962

PMID:3442824 - Genetic mapping of eleven spo genes essential for ascospore formation in the fission yeast Schizosaccharomyces pombe.

Kishida M et al. Curr Genet 1986;10(6):443-7

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:23173672 - Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.

Pan X et al. BMC Genomics 2012 Nov 23;13:662

PMID:1417417 - Electron microscopic examination of sporulation-deficient mutants of the fission yeast Schizosaccharomyces pombe.

Hirata A et al. Arch Microbiol 1992;158(4):249-55

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:29084823 - Phosphorylation of the RNA-binding protein Zfs1 modulates sexual differentiation in fission yeast.

Navarro FJ et al. J Cell Sci 2017 Dec 15;130(24):4144-4154

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:16303567 - A large-scale screen in S. pombe identifies seven novel genes required for critical meiotic events.

Martín-Castellanos C et al. Curr Biol 2005 Nov 22;15(22):2056-62

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.

Paulo JA et al. J Proteomics 2020 Jan 06;210:103531

PMID:24506453 - The RNA-binding protein Spo5 promotes meiosis II by regulating cyclin Cdc13 in fission yeast.

Arata M et al. Genes Cells 2014 Mar;19(3):225-38

PMID:21340088 - Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.

Arita Y et al. Mol Biosyst 2011 May;7(5):1463-72

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.

Rallis C et al. Sci Rep 2017 Mar 10;7:44257

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:21317872 - Red1 promotes the elimination of meiosis-specific mRNAs in vegetatively growing fission yeast.

Sugiyama T et al. EMBO J 2011 Mar 16;30(6):1027-39

PMID:20404563 - High-throughput knockout screen in Schizosaccharomyces pombe identifies a novel gene required for efficient homolog disjunction during meiosis I.

Rumpf C et al. Cell Cycle 2010 May;9(9):1802-8

PMID:23980030 - A novel factor Iss10 regulates Mmi1-mediated selective elimination of meiotic transcripts.

Yamashita A et al. Nucleic Acids Res 2013 Nov;41(21):9680-7

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.

Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101

PMID:28841135 - Ubiquitination-dependent control of sexual differentiation in fission yeast.

Simonetti F et al. Elife 2017 Aug 25;6

PMID:29694900 - Importin α and vNEBD Control Meiotic Spindle Disassembly in Fission Yeast.

Flor-Parra I et al. Cell Rep 2018 Apr 24;23(4):933-941

PMID:16896214 - Spo5/Mug12, a putative meiosis-specific RNA-binding protein, is essential for meiotic progression and forms Mei2 dot-like nuclear foci.

Kasama T et al. Eukaryot Cell 2006 Aug;5(8):1301-13

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:32012158 - Meiotic gene silencing complex MTREC/NURS recruits the nuclear exosome to YTH-RNA-binding protein Mmi1.

Shichino Y et al. PLoS Genet 2020 Feb;16(2):e1008598

PMID:24727291 - A genome-wide screen for sporulation-defective mutants in Schizosaccharomyces pombe.

Ucisik-Akkaya E et al. G3 (Bethesda) 2014 Apr 11;4(6):1173-82

PMID:23370392 - A knockout screen for protein kinases required for the proper meiotic segregation of chromosomes in the fission yeast Schizosaccharomyces pombe.

Kovacikova I et al. Cell Cycle 2013 Feb 15;12(4):618-24

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:20622014 - Negative regulation of meiotic gene expression by the nuclear poly(a)-binding protein in fission yeast.

St-André O et al. J Biol Chem 2010 Sep 03;285(36):27859-68

PMID:23658229 - Red5 and three nuclear pore components are essential for efficient suppression of specific mRNAs during vegetative growth of fission yeast.

Sugiyama T et al. Nucleic Acids Res 2013 Jul;41(13):6674-86

PMID:20970342 - Virtual breakdown of the nuclear envelope in fission yeast meiosis.

Asakawa H et al. Curr Biol 2010 Nov 09;20(21):1919-25

PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.

Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684

PMID:16823445 - Selective elimination of messenger RNA prevents an incidence of untimely meiosis.

Harigaya Y et al. Nature 2006 Jul 06;442(7098):45-50

PMID:35820914 - Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging.

Vega M et al. BMC Biol 2022 Jul 12;20(1):160

PMID:16615890 - Meiotic proteins bqt1 and bqt2 tether telomeres to form the bouquet arrangement of chromosomes.

Chikashige Y et al. Cell 2006 Apr 07;125(1):59-69

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:26670050 - Regulation of mRNA Levels by Decay-Promoting Introns that Recruit the Exosome Specificity Factor Mmi1.

Kilchert C et al. Cell Rep 2015 Dec 22;13(11):2504-2515

PMID:8203159 - Structural modification of spindle pole bodies during meiosis II is essential for the normal formation of ascospores in Schizosaccharomyces pombe: ultrastructural analysis of spo mutants.

Hirata A et al. Yeast 1994 Feb;10(2):173-83

PMID:25023750 - Functional significance of nuclear export and mRNA binding of meiotic regulator Spo5 in fission yeast.

Togashi N et al. BMC Microbiol 2014 Jul 15;14:188

PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.

Egan ED et al. RNA 2014 Jun;20(6):867-81