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protein coding gene - gas2 (SPBC29A10.08) - cell wall 1,3-beta-glucanosyltransferase Gas2

Gene summary

Standard name
gas2
Systematic ID
SPBC29A10.08
Product
cell wall 1,3-beta-glucanosyltransferase Gas2
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9USU5
ORFeome ID
51/51D07
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 2553939..2555531 forward strand

Annotation

GO biological process

GO:0071970 - fungal-type cell wall (1->3)-beta-D-glucan biosynthetic process

References:

GO:0031505 - fungal-type cell wall organization

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GO cellular component

GO:0043188 - cell septum edging

References:

GO:0051286 - cell tip

References:

GO:0009897 - external side of plasma membrane

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GO:0005576 - extracellular region

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GO molecular function

GO:0042124 - 1,3-beta-glucanosyltransferase activity

References:

Modification

MOD:00689 - disulfide crosslinked residues

References:

MOD:00818 - glycosylphosphatidylinositolated residue

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MOD:00006 - N-glycosylated residue

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Multi-locus phenotype

FYPO:0000182 - abnormal cell wall organization during vegetative growth

References:

Genotypes:

FYPO:0005158 - decreased cell wall (1->6)-beta-D-glucan level

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

Protein sequence feature

SO:0000418 - signal_peptide

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Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000018 - protein level increased

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PomGeneEx:0000012 - RNA level decreased

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PomGeneEx:0000017 - RNA level fluctuates

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0005158 - decreased cell wall (1->6)-beta-D-glucan level

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Genotypes:

FYPO:0000155 - increased flocculation

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

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Genotypes:

FYPO:0001453 - resistance to ethanol

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Genotypes:

FYPO:0001103 - resistance to hydrogen peroxide

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Genotypes:

FYPO:0001583 - resistance to lithium

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000095 - sensitive to bleomycin

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Genotypes:

FYPO:0007931 - sensitive to egtazic acid

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011063 - conserved in fungi only

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF07983X8X8PFAM
PF03198Glyco_hydro_72GlucanosyltransferasePFAM
SM00768X8_clsX8SMART
G3DSA:3.20.20.80:FF:000038FUNFAM
SSF51445(Trans)glycosidasesGH_hydrolase_sfSUPERFAMILY
G3DSA:3.20.20.80GlycosidasesGENE3D
G3DSA:1.20.58.1040GENE3D
PTHR314681,3-BETA-GLUCANOSYLTRANSFERASE GAS1GlucanosyltransferasePANTHER

Orthologs

References / Literature

PMID:40063661 - Fission yeast Caprin protein is required for efficient heterochromatin establishment.
Zhang H et al. PLoS Genet 2025 Mar 10;21(3):e1011620
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:38511077 - Generation and characterization of temperature-sensitive alleles of the glucanosyltransferase Gas1 in Schizosaccharomyces pombe.
Howard IV et al. MicroPubl Biol 2024;2024
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PB_REF:0000001 - Protein modification annotation by manual transfer of experimentally-verified annotation data to orthologs based on curator judgment of sequence features.
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:39660919 - Efn1 and Efn2 are extracellular 5'-nucleotidases induced during the fission yeast response to phosphate starvation.
Innokentev A et al. mBio 2024 Dec 11;:e0299224
PMID:38180730 - LAMMER Kinase Governs the Expression and Cellular Localization of Gas2, a Key Regulator of Flocculation in Schizosaccharomyces pombe.
Kang WH et al. J Microbiol 2024 Jan 05;
PMID:21124977 - β(1,3)-glucanosyl-transferase activity is essential for cell wall integrity and viability of Schizosaccharomyces pombe.
de Medina-Redondo M et al. PLoS One 2010 Nov 18;5(11):e14046
PMID:22633491 - Mapping N-glycosylation sites across seven evolutionarily distant species reveals a divergent substrate proteome despite a common core machinery.
Zielinska DF et al. Mol Cell 2012 May 25;46(4):542-8
PMID:27974503 - Traffic Through the Trans-Golgi Network and the Endosomal System Requires Collaboration Between Exomer and Clathrin Adaptors in Fission Yeast.
Hoya M et al. Genetics 2017 Feb;205(2):673-690
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:23236291 - Deciphering the transcriptional-regulatory network of flocculation in Schizosaccharomyces pombe.
Kwon EJ et al. PLoS Genet 2012;8(12):e1003104
PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.
Rallis C et al. Sci Rep 2017 Mar 10;7:44257
PMID:23066505 - The unfolded protein response in fission yeast modulates stability of select mRNAs to maintain protein homeostasis.
Kimmig P et al. Elife 2012 Oct 15;1:e00048
PMID:12845604 - Genome-wide identification of fungal GPI proteins.
De Groot PW et al. Yeast 2003 Jul 15;20(9):781-96
PMID:23956636 - Possible Roles of LAMMER Kinase Lkh1 in Fission Yeast by Comparative Proteome Analysis.
Cho SJ et al. Mycobiology 2010 Jun;38(2):108-12
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:38360270 - A KDELR-mediated ER-retrieval system modulates mitochondrial functions via the unfolded protein response in fission yeast.
Zhu M et al. J Biol Chem 2024 Feb 13;:105754
PMID:28821619 - Dsc E3 ligase localization to the Golgi requires the ATPase Cdc48 and cofactor Ufd1 for activation of sterol regulatory element-binding protein in fission yeast.
Burr R et al. J Biol Chem 2017 Sep 29;292(39):16333-16350
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23163955 - Analysis of stress-induced duplex destabilization (SIDD) properties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe.
Yadav MP et al. BMC Res Notes 2012 Nov 19;5:643
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36