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protein coding gene - tri1 (SPBC29A10.09c) - triman, ribonuclease involved in priRNA formation Tri1

Gene summary

Standard name
tri1
Systematic ID
SPBC29A10.09c
Product
triman, ribonuclease involved in priRNA formation Tri1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O94386
ORFeome ID
51/51D05
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 2554177..2556947 reverse strand

Annotation

Disease association

MONDO:0014600 - dyskeratosis congenita, autosomal recessive 6

References:

MONDO:0014612 - pulmonary fibrosis and/or bone marrow failure, Telomere-related, 4

References:

GO biological process

GO:1990431 - priRNA 3'-end processing

References:

GO:0031048 - regulatory ncRNA-mediated heterochromatin formation

References:

GO:1990432 - siRNA 3'-end processing

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GO cellular component

GO:0000779 - condensed chromosome, centromeric region

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GO:0005634 - nucleus

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GO molecular function

GO:0000175 - 3'-5'-RNA exonuclease activity

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GO:0004535 - poly(A)-specific ribonuclease activity

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GO:0003723 - RNA binding

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Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0003098 - abnormal heterochromatin assembly at centromere outer repeat during vegetative growth

References:

Genotypes:

FYPO:0000151 - abnormal meiotic chromosome segregation

References:

Genotypes:

FYPO:0002064 - abolished 3'-5'-exoribonuclease activity

References:

Genotypes:

FYPO:0000250 - decreased cell population growth on proline nitrogen source

References:

Genotypes:

FYPO:0003094 - decreased centromeric outer repeat transcript level

References:

Genotypes:

FYPO:0007223 - decreased establishment of chromatin silencing at centromere outer repeat region

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Genotypes:

FYPO:0003101 - decreased heterochromatin assembly at protein coding gene

References:

Genotypes:

FYPO:0003096 - decreased histone H3-K9 methylation at centromere outer repeat during vegetative growth

References:

Genotypes:

FYPO:0003103 - decreased mRNA-derived small RNA level

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Genotypes:

FYPO:0002134 - decreased protein-RNA interaction

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Genotypes:

FYPO:0003093 - increased Argonaute-associated RNA length

References:

Genotypes:

FYPO:0009098 - increased cell population growth on mannitol carbon source

References:

Genotypes:

FYPO:0006070 - increased small RNA 3' adenylation

References:

Genotypes:

FYPO:0004557 - increased vegetative cell population growth

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Genotypes:

FYPO:0003100 - normal heterochromatin assembly at protein coding gene

References:

Genotypes:

FYPO:0009036 - resistance to benzamidine

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Genotypes:

FYPO:0002693 - resistance to diamide

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Genotypes:

FYPO:0002578 - resistance to hydroxyurea

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Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000725 - resistance to methyl methanesulfonate

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Genotypes:

FYPO:0009039 - resistance to potassium chloride

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Genotypes:

FYPO:0009081 - resistance to potassium chloride and methyl methanesulfonate

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

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Genotypes:

FYPO:0001034 - resistance to tunicamycin

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Genotypes:

FYPO:0007931 - sensitive to egtazic acid

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Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0000055 - no apparent S. cerevisiae ortholog

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF04857CAF1RNase_CAF1Pfam
G3DSA:3.30.420.10RNaseH_sfCATH-Gene3D
SSF53098RNaseH-like_sfSUPERFAMILY
PTHR15092CAF1_poly(A)_ribonucleasesPANTHER

Orthologs

References / Literature

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:28541282 - Tailing and degradation of Argonaute-bound small RNAs protect the genome from uncontrolled RNAi.
Pisacane P et al. Nat Commun 2017 May 25;8:15332
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:40063661 - Fission yeast Caprin protein is required for efficient heterochromatin establishment.
Zhang H et al. PLoS Genet 2025 Mar 10;21(3):e1011620
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:24095277 - Argonaute and Triman generate dicer-independent priRNAs and mature siRNAs to initiate heterochromatin formation.
Marasovic M et al. Mol Cell 2013 Oct 24;52(2):173-83
PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.
Blyth J et al. Genetics 2018 Feb;208(2):589-603
PMID:19430462 - Decapping is preceded by 3' uridylation in a novel pathway of bulk mRNA turnover.
Rissland OS et al. Nat Struct Mol Biol 2009 Jun;16(6):616-23