protein coding gene - rec8 (SPBC29A10.14) - meiotic cohesin complex kleisin subunit Rec8

Gene summary

Standard name

rec8

Systematic ID

SPBC29A10.14

Product

meiotic cohesin complex kleisin subunit Rec8

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

P36626

ORFeome ID

51/51E03

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 2568938..2570993 forward strand

Annotation

Protein features

Orthologs

• REC8 (HGNC:16879) Homo sapiens
• rec8 (SJAG_03926) Schizosaccharomyces japonicus
• REC8 (YPR007C) Saccharomyces cerevisiae

References / Literature

PMID:20421495 - RNAi and heterochromatin repress centromeric meiotic recombination.

Ellermeier C et al. Proc Natl Acad Sci U S A 2010 May 11;107(19):8701-5

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:10207075 - Rec8p, a meiotic recombination and sister chromatid cohesion phosphoprotein of the Rad21p family conserved from fission yeast to humans.

Parisi S et al. Mol Cell Biol 1999 May;19(5):3515-28

PMID:28765164 - Selective termination of lncRNA transcription promotes heterochromatin silencing and cell differentiation.

Touat-Todeschini L et al. EMBO J 2017 Sep 01;36(17):2626-2641

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:16043696 - Cohesins are required for meiotic DNA breakage and recombination in Schizosaccharomyces pombe.

Ellermeier C et al. Proc Natl Acad Sci U S A 2005 Aug 02;102(31):10952-7

PMID:25579976 - Phosphorylation of cohesin Rec11/SA3 by casein kinase 1 promotes homologous recombination by assembling the meiotic chromosome axis.

Sakuno T et al. Dev Cell 2015 Jan 26;32(2):220-30

PMID:38448160 - Phosphorylation of Rec8 cohesin complexes regulates mono-orientation of kinetochores in meiosis I.

Liu Y et al. Life Sci Alliance 2024 May;7(5)

PMID:20383139 - Shugoshin-PP2A counteracts casein-kinase-1-dependent cleavage of Rec8 by separase.

Ishiguro T et al. Nat Cell Biol 2010 May;12(5):500-6

PMID:22912768 - Rhn1, a nuclear protein, is required for suppression of meiotic mRNAs in mitotically dividing fission yeast.

Sugiyama T et al. PLoS One 2012;7(8):e42962

PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.

Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101

PMID:8299939 - Region-specific activators of meiotic recombination in Schizosaccharomyces pombe.

DeVeaux LC et al. Genes Dev 1994 Jan;8(2):203-10

PMID:26670050 - Regulation of mRNA Levels by Decay-Promoting Introns that Recruit the Exosome Specificity Factor Mmi1.

Kilchert C et al. Cell Rep 2015 Dec 22;13(11):2504-2515

PMID:29898918 - Mutations that prevent methylation of cohesin render sensitivity to DNA damage in S. pombe .

Sanyal S et al. J Cell Sci 2018 Jul 06;131(13)

PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.

Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838

PMID:23658229 - Red5 and three nuclear pore components are essential for efficient suppression of specific mRNAs during vegetative growth of fission yeast.

Sugiyama T et al. Nucleic Acids Res 2013 Jul;41(13):6674-86

PMID:21920317 - Repositioning of aurora B promoted by chiasmata ensures sister chromatid mono-orientation in meiosis I.

Sakuno T et al. Dev Cell 2011 Sep 13;21(3):534-45

PMID:19454013 - Conserved features of cohesin binding along fission yeast chromosomes.

Schmidt CK et al. Genome Biol 2009;10(5):R52

PMID:2806887 - Meiotic recombination-deficient mutants of Schizosaccharomyces pombe.

Ponticelli AS et al. Genetics 1989 Sep;123(1):45-54

PMID:27365210 - The fission yeast MTREC and EJC orthologs ensure the maturation of meiotic transcripts during meiosis.

Marayati BF et al. RNA 2016 Sep;22(9):1349-59

PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.

Blyth J et al. Genetics 2018 Feb;208(2):589-603

PMID:14648198 - DSC1-MCB regulation of meiotic transcription in Schizosaccharomyces pombe.

Cunliffe L et al. Mol Genet Genomics 2004 Feb;271(1):60-71

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:23862021 - The C-terminus of S. pombe DDK subunit Dfp1 is required for meiosis-specific transcription and cohesin cleavage.

Le AH et al. Biol Open 2013 Jul 15;2(7):728-38

PMID:14730319 - The conserved kinetochore protein shugoshin protects centromeric cohesion during meiosis.

Kitajima TS et al. Nature 2004 Feb 05;427(6974):510-7

PMID:15226405 - S. pombe meiotic linear elements contain proteins related to synaptonemal complex components.

Lorenz A et al. J Cell Sci 2004 Jul 01;117(Pt 15):3343-51

PMID:16360688 - Control of Shugoshin function during fission-yeast meiosis.

Vaur S et al. Curr Biol 2005 Dec 20;15(24):2263-70

PMID:16541024 - Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I.

Riedel CG et al. Nature 2006 May 04;441(7089):53-61

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:23348717 - Essential role of Ubr11, but not Ubr1, as an N-end rule ubiquitin ligase in Schizosaccharomyces pombe.

Fujiwara H et al. Yeast 2013 Jan;30(1):1-11

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:31665745 - Conserved HORMA domain-containing protein Hop1 stabilizes interaction between proteins of meiotic DNA break hotspots and chromosome axis.

Kariyazono R et al. Nucleic Acids Res 2019 Nov 04;47(19):10166-10180

PMID:16303567 - A large-scale screen in S. pombe identifies seven novel genes required for critical meiotic events.

Martín-Castellanos C et al. Curr Biol 2005 Nov 22;15(22):2056-62

PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.

Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684

PMID:1339382 - Meiotically induced rec7 and rec8 genes of Schizosaccharomyces pombe.

Lin Y et al. Genetics 1992 Sep;132(1):75-85

PMID:33888556 - Meikin synergizes with shugoshin to protect cohesin Rec8 during meiosis I.

Ma W et al. Genes Dev 2021 May 01;35(9-10):692-697

PMID:18079700 - Cell-cycle regulation of cohesin stability along fission yeast chromosomes.

Bernard P et al. EMBO J 2008 Jan 09;27(1):111-21

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:10440376 - Cohesin Rec8 is required for reductional chromosome segregation at meiosis.

Watanabe Y et al. Nature 1999 Jul 29;400(6743):461-4

PMID:21317872 - Red1 promotes the elimination of meiosis-specific mRNAs in vegetatively growing fission yeast.

Sugiyama T et al. EMBO J 2011 Mar 16;30(6):1027-39

PMID:9671035 - Global control of meiotic recombination genes by Schizosaccharomyces pombe rec16 (rep1).

Ding R et al. Mol Gen Genet 1998 Jun;258(6):663-70

PMID:12727894 - Monopolar spindle attachment of sister chromatids is ensured by two distinct mechanisms at the first meiotic division in fission yeast.

Yamamoto A et al. EMBO J 2003 May 01;22(9):2284-96

PMID:12606573 - Function of Cdc2p-dependent Bub1p phosphorylation and Bub1p kinase activity in the mitotic and meiotic spindle checkpoint.

Yamaguchi S et al. EMBO J 2003 Mar 03;22(5):1075-87

PMID:12665553 - Linear element formation and their role in meiotic sister chromatid cohesion and chromosome pairing.

Molnar M et al. J Cell Sci 2003 May 01;116(Pt 9):1719-31

PMID:11331883 - Fission yeast Bub1 is essential in setting up the meiotic pattern of chromosome segregation.

Bernard P et al. Nat Cell Biol 2001 May;3(5):522-6

PMID:27851962 - Reconstitution of Targeted Deadenylation by the Ccr4-Not Complex and the YTH Domain Protein Mmi1.

Stowell JAW et al. Cell Rep 2016 Nov 15;17(8):1978-1989

PMID:31147914 - Analysis of the Chromosomal Localization of Yeast SMC Complexes by Chromatin Immunoprecipitation.

Makrantoni V et al. Methods Mol Biol 2019;2004:119-138

PMID:16615890 - Meiotic proteins bqt1 and bqt2 tether telomeres to form the bouquet arrangement of chromosomes.

Chikashige Y et al. Cell 2006 Apr 07;125(1):59-69

PMID:9778252 - RNA-assisted nuclear transport of the meiotic regulator Mei2p in fission yeast.

Yamashita A et al. Cell 1998 Oct 02;95(1):115-23

PMID:16823445 - Selective elimination of messenger RNA prevents an incidence of untimely meiosis.

Harigaya Y et al. Nature 2006 Jul 06;442(7098):45-50

PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.

Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7

PMID:23980030 - A novel factor Iss10 regulates Mmi1-mediated selective elimination of meiotic transcripts.

Yamashita A et al. Nucleic Acids Res 2013 Nov;41(21):9680-7

PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.

Egan ED et al. RNA 2014 Jun;20(6):867-81

PMID:34851403 - Direct evaluation of cohesin-mediated sister kinetochore associations at meiosis I in fission yeast.

Nambu M et al. J Cell Sci 2022 Jan 01;135(1)

PMID:18780734 - Cohesin and recombination proteins influence the G1-to-S transition in azygotic meiosis in Schizosaccharomyces pombe.

Doll E et al. Genetics 2008 Oct;180(2):727-40

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.

Mata J et al. Nat Genet 2002 Sep;32(1):143-7

PMID:16541025 - Shugoshin collaborates with protein phosphatase 2A to protect cohesin.

Kitajima TS et al. Nature 2006 May 04;441(7089):46-52

PMID:19965387 - Phosphorylation of H2A by Bub1 prevents chromosomal instability through localizing shugoshin.

Kawashima SA et al. Science 2010 Jan 08;327(5962):172-7

PMID:23395004 - Protein determinants of meiotic DNA break hot spots.

Fowler KR et al. Mol Cell 2013 Mar 07;49(5):983-96

PMID:10882124 - Meiotic DNA breaks associated with recombination in S. pombe.

Cervantes MD et al. Mol Cell 2000 May;5(5):883-8

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:28199302 - Untimely expression of gametogenic genes in vegetative cells causes uniparental disomy.

Folco HD et al. Nature 2017 Mar 02;543(7643):126-130

PMID:31278118 - Cohesin Impedes Heterochromatin Assembly in Fission Yeast Cells Lacking Pds5.

Folco HD et al. Genetics 2019 Sep;213(1):127-141

PMID:32012158 - Meiotic gene silencing complex MTREC/NURS recruits the nuclear exosome to YTH-RNA-binding protein Mmi1.

Shichino Y et al. PLoS Genet 2020 Feb;16(2):e1008598

PMID:20581463 - Casein kinase 1 is required for efficient removal of Rec8 during meiosis I.

Rumpf C et al. Cell Cycle 2010 Jul 01;9(13):2657-62

PMID:15893732 - Negative control contributes to an extensive program of meiotic splicing in fission yeast.

Averbeck N et al. Mol Cell 2005 May 13;18(4):491-8

PMID:12748297 - Cohesins determine the attachment manner of kinetochores to spindle microtubules at meiosis I in fission yeast.

Yokobayashi S et al. Mol Cell Biol 2003 Jun;23(11):3965-73

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

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PMID:8536990 - The rec8 gene of Schizosaccharomyces pombe is involved in linear element formation, chromosome pairing and sister-chromatid cohesion during meiosis.

Molnar M et al. Genetics 1995 Sep;141(1):61-73

PMID:14972679 - Two fission yeast homologs of Drosophila Mei-S332 are required for chromosome segregation during meiosis I and II.

Rabitsch KP et al. Curr Biol 2004 Feb 17;14(4):287-301

PMID:35333350 - Rec8 Cohesin-mediated Axis-loop chromatin architecture is required for meiotic recombination.

Sakuno T et al. Nucleic Acids Res 2022 Apr 22;50(7):3799-3816

PMID:16532353 - Meiotic recombination proteins localize to linear elements in Schizosaccharomyces pombe.

Lorenz A et al. Chromosoma 2006 Aug;115(4):330-40

PMID:9136000 - The Schizosaccharomyces pombe rec16 gene product regulates multiple meiotic events.

Li YF et al. Genetics 1997 May;146(1):57-67

PMID:32317395 - Translesion synthesis polymerases contribute to meiotic chromosome segregation and cohesin dynamics in S chizosaccharomyces pombe .

Mastro TL et al. J Cell Sci 2020 May 22;133(10)

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:32790622 - Atypical meiosis can be adaptive in outcrossed Schizosaccharomyces pombe due to wtf meiotic drivers.

Bravo Núñez MA et al. Elife 2020 Aug 13;9

PMID:12750522 - Distinct cohesin complexes organize meiotic chromosome domains.

Kitajima TS et al. Science 2003 May 16;300(5622):1152-5

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:10471700 - Meiotic chromosome dynamics dependent upon the rec8(+), rec10(+) and rec11(+) genes of the fission yeast Schizosaccharomyces pombe.

Krawchuk MD et al. Genetics 1999 Sep;153(1):57-68

PMID:16325576 - The kinetochore protein Moa1 enables cohesion-mediated monopolar attachment at meiosis I.

Yokobayashi S et al. Cell 2005 Dec 02;123(5):803-17

PMID:14532136 - Rec8 cleavage by separase is required for meiotic nuclear divisions in fission yeast.

Kitajima TS et al. EMBO J 2003 Oct 15;22(20):5643-53

PMID:22292001 - SCF ensures meiotic chromosome segregation through a resolution of meiotic recombination intermediates.

Okamoto SY et al. PLoS One 2012;7(1):e30622

PMID:41786187 - Shugoshin holds the potential to inhibit APC/C and thereby prevents separase activation.

Zhang K et al. Int J Biol Macromol 2026 Mar 03;:151175

PMID:30217891 - Physical basis for long-distance communication along meiotic chromosomes.

Fowler KR et al. Proc Natl Acad Sci U S A 2018 Oct 02;115(40):E9333-E9342

PMID:25993311 - Casein Kinase 1 and Phosphorylation of Cohesin Subunit Rec11 (SA3) Promote Meiotic Recombination through Linear Element Formation.

Phadnis N et al. PLoS Genet 2015 May;11(5):e1005225

PMID:18514516 - Rec25 and Rec27, novel linear-element components, link cohesin to meiotic DNA breakage and recombination.

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PMID:28841135 - Ubiquitination-dependent control of sexual differentiation in fission yeast.

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