protein coding gene - orc1 (SPBC29A10.15) - origin recognition complex subunit Orc1

Gene summary

Standard name

orc1

Systematic ID

SPBC29A10.15

Product

origin recognition complex subunit Orc1

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

orp1, cdc30, rid1

UniProt ID

P54789

ORFeome ID

51/51E07

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 2571101..2573477 forward strand

Annotation

Protein features

Orthologs

• ORC1 (HGNC:8487) Homo sapiens
• orc1 (SJAG_03927) Schizosaccharomyces japonicus
• ORC1 (YML065W) Saccharomyces cerevisiae

References / Literature

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:31474649 - Identification of 15 New Bypassable Essential Genes of Fission Yeast.

Takeda A et al. Cell Struct Funct 2019 Sep 27;44(2):113-119

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:11606526 - Characterization of Schizosaccharomyces pombe mcm7(+) and cdc23(+) (MCM10) and interactions with replication checkpoints.

Liang DT et al. Genetics 2001 Oct;159(2):471-86

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:12574132 - Multiple ORC-binding sites are required for efficient MCM loading and origin firing in fission yeast.

Takahashi T et al. EMBO J 2003 Feb 17;22(4):964-74

PMID:29036220 - Defective replication initiation results in locus specific chromosome breakage and a ribosomal RNA deficiency in yeast.

Sanchez JC et al. PLoS Genet 2017 Oct;13(10):e1007041

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:28718400 - Histone H3G34R mutation causes replication stress, homologous recombination defects and genomic instability in S. pombe .

Yadav RK et al. Elife 2017 Jul 18;6

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PMID:10588642 - Nuclear localization of Schizosaccharomyces pombe Mcm2/Cdc19p requires MCM complex assembly.

Pasion SG et al. Mol Biol Cell 1999 Dec;10(12):4043-57

GO_REF:0000002 - Comments

PMID:11683912 - Interaction of fission yeast ORC with essential adenine/thymine stretches in replication origins.

Takahashi T et al. Genes Cells 2001 Oct;6(10):837-49

PMID:15314153 - The B-subunit of DNA polymerase alpha-primase associates with the origin recognition complex for initiation of DNA replication.

Uchiyama M et al. Mol Cell Biol 2004 Sep;24(17):7419-34

PMID:16199868 - Schizosaccharomyces pombe mst2+ encodes a MYST family histone acetyltransferase that negatively regulates telomere silencing.

Gómez EB et al. Mol Cell Biol 2005 Oct;25(20):8887-903

PMID:23322785 - The fission yeast minichromosome maintenance (MCM)-binding protein (MCM-BP), Mcb1, regulates MCM function during prereplicative complex formation in DNA replication.

Santosa V et al. J Biol Chem 2013 Mar 08;288(10):6864-80

PMID:9914167 - Reduced dosage of a single fission yeast MCM protein causes genetic instability and S phase delay.

Liang DT et al. J Cell Sci 1999 Feb;112 ( Pt 4):559-67

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:7502077 - Conserved initiator proteins in eukaryotes.

Gavin KA et al. Science 1995 Dec 08;270(5242):1667-71

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:11027263 - Schizosaccharomyces pombe Hsk1p is a potential cds1p target required for genome integrity.

Snaith HA et al. Mol Cell Biol 2000 Nov;20(21):7922-32

PMID:8895665 - The ORC1 homolog orp1 in fission yeast plays a key role in regulating onset of S phase.

Grallert B et al. Genes Dev 1996 Oct 15;10(20):2644-54

PMID:12185500 - Fission yeast Cdc23 interactions with DNA replication initiation proteins.

Hart EA et al. Curr Genet 2002 Aug;41(5):342-8

PMID:17112379 - The CENP-B homolog, Abp1, interacts with the initiation protein Cdc23 (MCM10) and is required for efficient DNA replication in fission yeast.

Locovei AM et al. Cell Div 2006 Nov 17;1:27

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:27984725 - CDK Substrate Phosphorylation and Ordering the Cell Cycle.

Swaffer MP et al. Cell 2016 Dec 15;167(7):1750-1761.e16

PMID:10523506 - The fission yeast origin recognition complex is constitutively associated with chromatin and is differentially modified through the cell cycle.

Lygerou Z et al. J Cell Sci 1999 Nov;112 ( Pt 21):3703-12

PMID:10490657 - Association of fission yeast Orp1 and Mcm6 proteins with chromosomal replication origins.

Ogawa Y et al. Mol Cell Biol 1999 Oct;19(10):7228-36

PMID:11717425 - The Schizosaccharomyces pombe origin recognition complex interacts with multiple AT-rich regions of the replication origin DNA by means of the AT-hook domains of the spOrc4 protein.

Lee JK et al. Proc Natl Acad Sci U S A 2001 Nov 20;98(24):13589-94

PMID:16849602 - Regulation of DNA replication machinery by Mrc1 in fission yeast.

Nitani N et al. Genetics 2006 Sep;174(1):155-65

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.

PMID:10888871 - Mitotic replication initiation proteins are not required for pre-meiotic S phase.

Forsburg SL et al. Nat Genet 2000 Jul;25(3):263-8

PMID:11850415 - Purification and characterization of the Schizosaccharomyces pombe origin recognition complex: interaction with origin DNA and Cdc18 protein.

Chuang RY et al. J Biol Chem 2002 May 10;277(19):16920-7

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:9392077 - Measurement of nuclear DNA content in fission yeast by flow cytometry.

Carlson CR et al. Yeast 1997 Nov;13(14):1329-35

PMID:20799962 - A genetic screen for replication initiation defective (rid) mutants in Schizosaccharomyces pombe.

Locovei AM et al. Cell Div 2010 Aug 27;5:20

PMID:10747035 - Chromatin binding of the fission yeast replication factor mcm4 occurs during anaphase and requires ORC and cdc18.

Kearsey SE et al. EMBO J 2000 Apr 03;19(7):1681-90

PMID:18667534 - Activation of the DNA damage checkpoint in mutants defective in DNA replication initiation.

Yin L et al. Mol Biol Cell 2008 Oct;19(10):4374-82

PMID:11689699 - Site-specific DNA binding of the Schizosaccharomyces pombe origin recognition complex is determined by the Orc4 subunit.

Kong D et al. Mol Cell Biol 2001 Dec;21(23):8095-103

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:12419251 - Stable association of mitotic cyclin B/Cdc2 to replication origins prevents endoreduplication.

Wuarin J et al. Cell 2002 Nov 01;111(3):419-31

PMID:22366461 - Brc1-dependent recovery from replication stress.

Bass KL et al. J Cell Sci 2012 Jun 01;125(Pt 11):2753-64

PMID:10535928 - Identification and reconstitution of the origin recognition complex from Schizosaccharomyces pombe.

Moon KY et al. Proc Natl Acad Sci U S A 1999 Oct 26;96(22):12367-72

PMID:18505873 - Schizosaccharomyces pombe histone acetyltransferase Mst1 (KAT5) is an essential protein required for damage response and chromosome segregation.

Gómez EB et al. Genetics 2008 Jun;179(2):757-71

PMID:15194812 - A novel intermediate in initiation complex assembly for fission yeast DNA replication.

Yamada Y et al. Mol Biol Cell 2004 Aug;15(8):3740-50

PMID:18257517 - Phosphoproteome analysis of fission yeast.

Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97

PMID:18723846 - Multiple mechanisms contribute to Schizosaccharomyces pombe origin recognition complex-DNA interactions.

Houchens CR et al. J Biol Chem 2008 Oct 31;283(44):30216-24

PMID:17304213 - Genome-wide localization of pre-RC sites and identification of replication origins in fission yeast.

Hayashi M et al. EMBO J 2007 Mar 07;26(5):1327-39

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:10388806 - Rereplication phenomenon in fission yeast requires MCM proteins and other S phase genes.

Snaith HA et al. Genetics 1999 Jul;152(3):839-51

PMID:11988741 - Maintenance of replication forks and the S-phase checkpoint by Cdc18p and Orp1p.

Murakami H et al. Nat Cell Biol 2002 May;4(5):384-8

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:12186947 - A novel chk1-dependent G1/M checkpoint in fission yeast.

Synnes M et al. J Cell Sci 2002 Sep 15;115(Pt 18):3609-18

PMID:23349636 - Coordinated degradation of replisome components ensures genome stability upon replication stress in the absence of the replication fork protection complex.

Roseaulin LC et al. PLoS Genet 2013;9(1):e1003213

PMID:8618924 - Orp1, a member of the Cdc18/Cdc6 family of S-phase regulators, is homologous to a component of the origin recognition complex.

Muzi-Falconi M et al. Proc Natl Acad Sci U S A 1995 Dec 19;92(26):12475-9

PMID:15388803 - Identification and cloning of two putative subunits of DNA polymerase epsilon in fission yeast.

Spiga MG et al. Nucleic Acids Res 2004;32(16):4945-53

PMID:12840006 - Xenopus origin recognition complex (ORC) initiates DNA replication preferentially at sequences targeted by Schizosaccharomyces pombe ORC.

Kong D et al. EMBO J 2003 Jul 01;22(13):3441-50