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protein coding gene - lam1 (SPBC29A10.17) - Ragulator complex subunit, human LAMTOR1 ortholog

Gene summary

Standard name
lam1
Systematic ID
SPBC29A10.17
Product
Ragulator complex subunit, human LAMTOR1 ortholog
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
C6Y4C6
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 2573746..2575822 forward strand

Annotation

GO biological process

GO:1903432 - regulation of TORC1 signaling

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GO cellular component

GO:0000329 - fungal-type vacuole membrane

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GO:0071986 - Ragulator complex

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Modification

MOD:00046 - O-phospho-L-serine

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MOD:00047 - O-phospho-L-threonine

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MOD:01148 - ubiquitinylated lysine

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Multi-locus phenotype

FYPO:0001407 - decreased cell population growth on glucose carbon source

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Genotypes:

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0004249 - abnormal protein localization to vacuolar membrane

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Genotypes:

FYPO:0004250 - abolished protein localization to vacuolar membrane

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Genotypes:

FYPO:0001407 - decreased cell population growth on glucose carbon source

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Genotypes:

FYPO:0001522 - normal growth on caffeine

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Genotypes:

FYPO:0002672 - normal growth on rapamycin

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Genotypes:

FYPO:0004248 - normal protein localization to vacuolar membrane

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Genotypes:

FYPO:0006344 - protein mislocalized to plasma membrane during vegetative growth

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Genotypes:

FYPO:0001029 - resistance to canavanine

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Genotypes:

FYPO:0001453 - resistance to ethanol

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

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PBO:0011071 - conserved in eukaryotes only

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PBO:0011064 - conserved in fungi

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PBO:0011069 - conserved in metazoa

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PBO:0011070 - conserved in vertebrates

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PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000070 - gene structure updated

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PBO:0000082 - new gene

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Protein features

IDNameInterPro nameDB name
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder
mobidb-lite-Polardisorder_predictionMobiDB-Polar

Orthologs

References / Literature

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:29199950 - Ragulator and GATOR1 complexes promote fission yeast growth by attenuating TOR complex 1 through Rag GTPases.
Chia KH et al. Elife 2017 Dec 04;6
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:34296454 - The TOR-dependent phosphoproteome and regulation of cellular protein synthesis.
Mak T et al. EMBO J 2021 Aug 16;40(16):e107911
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.
Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838
PMID:18488015 - Dynamic repertoire of a eukaryotic transcriptome surveyed at single-nucleotide resolution.
Wilhelm BT et al. Nature 2008 Jun 26;453(7199):1239-43
PMID:21270388 - Augmented annotation of the Schizosaccharomyces pombe genome reveals additional genes required for growth and viability.
Bitton DA et al. Genetics 2011 Apr;187(4):1207-17
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87