protein coding gene - trt1 (SPBC29A3.14c) - telomerase reverse transcriptase 1 protein Trt1

Gene summary

Standard name

trt1

Systematic ID

SPBC29A3.14c

Product

telomerase reverse transcriptase 1 protein Trt1

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

O13339

ORFeome ID

41/41A09

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 2062472..2066110 reverse strand

Annotation

Protein features

Orthologs

• TERT (HGNC:11730) Homo sapiens
• trt1 (SJAG_05979) Schizosaccharomyces japonicus
• EST2 (YLR318W) Saccharomyces cerevisiae

References / Literature

PMID:11349150 - Pot1, the putative telomere end-binding protein in fission yeast and humans.

Baumann P et al. Science 2001 May 11;292(5519):1171-5

PMID:21760946 - Identification of genes affecting the toxicity of anti-cancer drug bortezomib by genome-wide screening in S. pombe.

Takeda K et al. PLoS One 2011;6(7):e22021

PMID:25245948 - Tls1 regulates splicing of shelterin components to control telomeric heterochromatin assembly and telomere length.

Wang J et al. Nucleic Acids Res 2014 Oct;42(18):11419-32

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:31289327 - Telomere DNA length-dependent regulation of DNA replication timing at internal late replication origins.

Hasegawa Y et al. Sci Rep 2019 Jul 09;9(1):9946

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:22215813 - Schizosaccharomyces pombe Ccq1 and TER1 bind the 14-3-3-like domain of Est1, which promotes and stabilizes telomerase-telomere association.

Webb CJ et al. Genes Dev 2012 Jan 01;26(1):82-91

PB_REF:0000003 - Disease Association Curation

PMID:22252817 - A genomewide screen in Schizosaccharomyces pombe for genes affecting the sensitivity of antifungal drugs that target ergosterol biosynthesis.

Fang Y et al. Antimicrob Agents Chemother 2012 Apr;56(4):1949-59

PMID:24013504 - Tpz1 controls a telomerase-nonextendible telomeric state and coordinates switching to an extendible state via Ccq1.

Jun HI et al. Genes Dev 2013 Sep 01;27(17):1917-31

PMID:26804021 - Shugoshin forms a specialized chromatin domain at subtelomeres that regulates transcription and replication timing.

Tashiro S et al. Nat Commun 2016 Jan 25;7:10393

PMID:12058079 - Schizosaccharomyces pombe pfh1+ encodes an essential 5' to 3' DNA helicase that is a member of the PIF1 subfamily of DNA helicases.

Zhou JQ et al. Mol Biol Cell 2002 Jun;13(6):2180-91

PMID:22302936 - Tel1(ATM) and Rad3(ATR) phosphorylate the telomere protein Ccq1 to recruit telomerase and elongate telomeres in fission yeast.

Yamazaki H et al. Genes Dev 2012 Feb 01;26(3):241-6

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:15485922 - Fission yeast Dna2 is required for generation of the telomeric single-strand overhang.

Tomita K et al. Mol Cell Biol 2004 Nov;24(21):9557-67

PMID:12697806 - Replication proteins influence the maintenance of telomere length and telomerase protein stability.

Dahlén M et al. Mol Cell Biol 2003 May;23(9):3031-42

PMID:18157152 - TER1, the RNA subunit of fission yeast telomerase.

Leonardi J et al. Nat Struct Mol Biol 2008 Jan;15(1):26-33

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:24925530 - Tpz1TPP1 SUMOylation reveals evolutionary conservation of SUMO-dependent Stn1 telomere association.

Garg M et al. EMBO Rep 2014 Aug;15(8):871-7

PMID:29422503 - LARP7-like protein Pof8 regulates telomerase assembly and poly(A)+TERRA expression in fission yeast.

Mennie AK et al. Nat Commun 2018 Feb 08;9(1):586

PMID:26896847 - Ensembl comparative genomics resources.

Herrero J et al. Database (Oxford) 2016;2016

PMID:28981863 - Subtelomeres constitute a safeguard for gene expression and chromosome homeostasis.

Tashiro S et al. Nucleic Acids Res 2017 Oct 13;45(18):10333-10349

PMID:35277511 - The methyl phosphate capping enzyme Bmc1/Bin3 is a stable component of the fission yeast telomerase holoenzyme.

Porat J et al. Nat Commun 2022 Mar 11;13(1):1277

PMID:20625380 - A genome-wide screen for Schizosaccharomyces pombe deletion mutants that affect telomere length.

Liu NN et al. Cell Res 2010 Aug;20(8):963-5

PMID:29298360 - Chromosome passenger complex is required for the survival of cells with ring chromosomes in fission yeast.

Habib AGK et al. PLoS One 2018;13(1):e0190523

PMID:17429064 - Fission yeast Taz1 and RPA are synergistically required to prevent rapid telomere loss.

Kibe T et al. Mol Biol Cell 2007 Jun;18(6):2378-87

PMID:27253066 - Multi-step coordination of telomerase recruitment in fission yeast through two coupled telomere-telomerase interfaces.

Hu X et al. Elife 2016 Jun 02;5

PMID:29216371 - Fission yeast Ccq1 is a modulator of telomerase activity.

Armstrong CA et al. Nucleic Acids Res 2018 Jan 25;46(2):704-716

PMID:20505337 - Roles of the checkpoint sensor clamp Rad9-Rad1-Hus1 (911)-complex and the clamp loaders Rad17-RFC and Ctf18-RFC in Schizosaccharomyces pombe telomere maintenance.

Khair L et al. Cell Cycle 2010 Jun 01;9(11):2237-48

PMID:15642092 - Global expression changes resulting from loss of telomeric DNA in fission yeast.

Mandell JG et al. Genome Biol 2005;6(1):R1

PMID:23188080 - The fission yeast MRN complex tethers dysfunctional telomeres for NHEJ repair.

Reis CC et al. EMBO J 2012 Dec 12;31(24):4576-86

PMID:26305931 - Telomerase RNA stem terminus element affects template boundary element function, telomere sequence, and shelterin binding.

Webb CJ et al. Proc Natl Acad Sci U S A 2015 Sep 08;112(36):11312-7

PMID:29422501 - LARP7 family proteins have conserved function in telomerase assembly.

Collopy LC et al. Nat Commun 2018 Feb 08;9(1):557

PMID:18157149 - Identification and characterization of the Schizosaccharomyces pombe TER1 telomerase RNA.

Webb CJ et al. Nat Struct Mol Biol 2008 Jan;15(1):34-42

PMID:29654060 - RNAi drives nonreciprocal translocations at eroding chromosome ends to establish telomere-free linear chromosomes.

Begnis M et al. Genes Dev 2018 Apr 01;32(7-8):537-554

PMID:23335786 - Spontaneous telomere to telomere fusions occur in unperturbed fission yeast cells.

Almeida H et al. Nucleic Acids Res 2013 Mar 01;41(5):3056-67

PMID:12861005 - Competition between the Rad50 complex and the Ku heterodimer reveals a role for Exo1 in processing double-strand breaks but not telomeres.

Tomita K et al. Mol Cell Biol 2003 Aug;23(15):5186-97

PMID:30148840 - Tdp1 processes chromate-induced single-strand DNA breaks that collapse replication forks.

Ganguly A et al. PLoS Genet 2018 Aug;14(8):e1007595

PMID:30321377 - Proteomic profiling and functional characterization of post-translational modifications of the fission yeast RNA exosome.

Telekawa C et al. Nucleic Acids Res 2018 Nov 30;46(21):11169-11183

PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.

Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)

PMID:25131669 - Telomerase activation after recruitment in fission yeast.

Armstrong CA et al. Curr Biol 2014 Sep 08;24(17):2006-11

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:25330395 - Tpz1-Ccq1 and Tpz1-Poz1 interactions within fission yeast shelterin modulate Ccq1 Thr93 phosphorylation and telomerase recruitment.

Harland JL et al. PLoS Genet 2014 Oct;10(10):e1004708

PMID:26628015 - Characterization of Tamoxifen as an Antifungal Agent Using the Yeast Schizosaccharomyces Pombe Model Organism.

Zhang X et al. Kobe J Med Sci 2015 Oct 09;61(2):E54-63

PMID:19264558 - Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.

Deshpande GP et al. DNA Repair (Amst) 2009 May 01;8(5):672-9

PMID:9336465 - Identification and characterization of a telomerase activity from Schizosaccharomyces pombe.

Lue NF et al. Nucleic Acids Res 1997 Nov 01;25(21):4331-7

PMID:23738021 - A genome-wide screening of potential target genes to enhance the antifungal activity of micafungin in Schizosaccharomyces pombe.

Zhou X et al. PLoS One 2013;8(5):e65904

PMID:9252327 - Telomerase catalytic subunit homologs from fission yeast and human.

Nakamura TM et al. Science 1997 Aug 15;277(5328):955-9

PMID:18722173 - Chromosome fusions following telomere loss are mediated by single-strand annealing.

Wang X et al. Mol Cell 2008 Aug 22;31(4):463-473

PMID:20040595 - Roles of heterochromatin and telomere proteins in regulation of fission yeast telomere recombination and telomerase recruitment.

Khair L et al. J Biol Chem 2010 Feb 19;285(8):5327-37

PMID:20537132 - Global fitness profiling of fission yeast deletion strains by barcode sequencing.

Han TX et al. Genome Biol 2010;11(6):R60

PMID:11029034 - Protection of telomeres by the Ku protein in fission yeast.

Baumann P et al. Mol Biol Cell 2000 Oct;11(10):3265-75

PMID:18160711 - Recombination-based telomere maintenance is dependent on Tel1-MRN and Rap1 and inhibited by telomerase, Taz1, and Ku in fission yeast.

Subramanian L et al. Mol Cell Biol 2008 Mar;28(5):1443-55

PMID:33378677 - Quality-Control Mechanism for Telomerase RNA Folding in the Cell.

Hu X et al. Cell Rep 2020 Dec 29;33(13):108568

PMID:22313747 - A double mutant between fission yeast telomerase and RecQ helicase is sensitive to thiabendazole, an anti-microtubule drug.

Ukimori S et al. Biosci Biotechnol Biochem 2012;76(2):264-9

PMID:26990647 - Swi1Timeless Prevents Repeat Instability at Fission Yeast Telomeres.

Gadaleta MC et al. PLoS Genet 2016 Mar;12(3):e1005943

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:25398909 - Fission yeast Cactin restricts telomere transcription and elongation by controlling Rap1 levels.

Lorenzi LE et al. EMBO J 2015 Jan 02;34(1):115-29

PMID:26365187 - Dissecting Fission Yeast Shelterin Interactions via MICro-MS Links Disruption of Shelterin Bridge to Tumorigenesis.

Liu J et al. Cell Rep 2015 Sep 29;12(12):2169-80

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.

PMID:12196391 - Telomere binding of checkpoint sensor and DNA repair proteins contributes to maintenance of functional fission yeast telomeres.

Nakamura TM et al. Genetics 2002 Aug;161(4):1437-52

PMID:24793650 - Structural basis for protein-RNA recognition in telomerase.

Huang J et al. Nat Struct Mol Biol 2014 Jun;21(6):507-12

PMID:25076038 - Large scale screening of genetic interaction with sgf73(+) in fission yeast.

Guo Y et al. Yi Chuan 2014 Jul;36(7):723-31

PMID:12676088 - Telomere maintenance in fission yeast requires an Est1 ortholog.

Beernink HT et al. Curr Biol 2003 Apr 01;13(7):575-80

PMID:22446625 - Telomerase RNA biogenesis involves sequential binding by Sm and Lsm complexes.

Tang W et al. Nature 2012 Mar 25;484(7393):260-4

PMID:24240238 - Elimination of shelterin components bypasses RNAi for pericentric heterochromatin assembly.

Tadeo X et al. Genes Dev 2013 Nov 15;27(22):2489-99

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:19214192 - Differential arrival of leading and lagging strand DNA polymerases at fission yeast telomeres.

Moser BA et al. EMBO J 2009 Apr 08;28(7):810-20

PMID:23950735 - Global analysis of fission yeast mating genes reveals new autophagy factors.

Sun LL et al. PLoS Genet 2013;9(8):e1003715

PMID:30796050 - Ssu72 phosphatase is a conserved telomere replication terminator.

Escandell JM et al. EMBO J 2019 Apr 01;38(7)

PMID:9774280 - Two modes of survival of fission yeast without telomerase.

Nakamura TM et al. Science 1998 Oct 16;282(5388):493-6