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protein coding gene - bmc1 (SPBC2A9.10) - snRNA and snoRNA methyltransferase Bmc1

Gene summary

Standard name
bmc1
Systematic ID
SPBC2A9.10
Product
snRNA and snoRNA methyltransferase Bmc1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
bin3
UniProt ID
Q9Y7L2
ORFeome ID
11/11B04
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 2964103..2965576 forward strand

Annotation

GO biological process

GO:0016180 - snRNA processing

References:

GO:0000723 - telomere maintenance

References:

GO cellular component

GO:0005732 - sno(s)RNA-containing ribonucleoprotein complex

References:

GO:0005697 - telomerase holoenzyme complex

References:

GO molecular function

GO:1990276 - RNA 5'-gamma-phosphate methyltransferase activity

References:

GO:0030515 - snoRNA binding

References:

GO:0017069 - snRNA binding

References:

Multi-locus phenotype

FYPO:0006849 - increased total RNA level during vegetative growth

References:

Genotypes:

FYPO:0002239 - shortened telomeres during vegetative growth

References:

Genotypes:

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0008112 - abnormal U6 snRNP assembly

References:

Genotypes:

FYPO:0002133 - abolished protein-RNA interaction

References:

Genotypes:

FYPO:0003244 - decreased mRNA splicing, via spliceosome, intron-specific

References:

Genotypes:

FYPO:0002134 - decreased protein-RNA interaction

References:

Genotypes:

FYPO:0005540 - decreased telomerase RNA reverse transcriptase activity

References:

Genotypes:

FYPO:0006848 - decreased total RNA level during vegetative growth

References:

Genotypes:

FYPO:0008110 - decreased U6 2'-O-snRNA methylation at residue A64

References:

Genotypes:

FYPO:0008113 - increased intron retention

References:

Genotypes:

FYPO:0002239 - shortened telomeres during vegetative growth

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0000055 - no apparent S. cerevisiae ortholog

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF06859Bin3Bin3_CPfam
PF13649Methyltransf_25Methyltransf_25Pfam
cd02440AdoMet_MTasesCDD
PS51515BIN3_SAMBIN3_SAM-bd_domPROSITE profiles
G3DSA:3.40.50.150SAM-dependent_MTases_sfCATH-Gene3D
SSF53335SAM-dependent_MTases_sfSUPERFAMILY
PTHR12315Bin3-likePANTHER

Orthologs

References / Literature

GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:37403782 - The fission yeast methyl phosphate capping enzyme Bmc1 guides 2'-O-methylation of the U6 snRNA.
Porat J et al. Nucleic Acids Res 2023 Sep 08;51(16):8805-8819
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:35277511 - The methyl phosphate capping enzyme Bmc1/Bin3 is a stable component of the fission yeast telomerase holoenzyme.
Porat J et al. Nat Commun 2022 Mar 11;13(1):1277
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83