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protein coding gene - orc6 (SPBC2A9.12) - origin recognition complex subunit Orc6

Gene summary

Standard name
orc6
Systematic ID
SPBC2A9.12
Product
origin recognition complex subunit Orc6
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPBC2D10.02
UniProt ID
O74796
ORFeome ID
11/11C03
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 2967253..2968262 forward strand

Annotation

Disease association

MONDO:0016817 - Meier-Gorlin syndrome

References:

MONDO:0013430 - Meier-Gorlin syndrome 3

References:

GO biological process

GO:0006270 - DNA replication initiation

References:

GO cellular component

GO:0000785 - chromatin

References:

GO:0005829 - cytosol

References:

GO:0031261 - DNA replication preinitiation complex

References:

GO:0005664 - nuclear origin of replication recognition complex

References:

GO:0005656 - nuclear pre-replicative complex

References:

GO:0043596 - nuclear replication fork

References:

GO:0005634 - nucleus

References:

GO molecular function

GO:0003688 - DNA replication origin binding

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000059 - abnormal mitotic cell cycle

References:

Genotypes:

FYPO:0001490 - inviable elongated vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0001511 - inviable vegetative cell, abnormal cell shape, normal cell size

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF05460ORC6ORC6_cyclin_firstPfam
PTHR13394ORC6_met/plnPANTHER

Orthologs

References / Literature

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:12185500 - Fission yeast Cdc23 interactions with DNA replication initiation proteins.
Hart EA et al. Curr Genet 2002 Aug;41(5):342-8
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:10535928 - Identification and reconstitution of the origin recognition complex from Schizosaccharomyces pombe.
Moon KY et al. Proc Natl Acad Sci U S A 1999 Oct 26;96(22):12367-72
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:18723846 - Multiple mechanisms contribute to Schizosaccharomyces pombe origin recognition complex-DNA interactions.
Houchens CR et al. J Biol Chem 2008 Oct 31;283(44):30216-24
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PB_REF:0000003 - Disease Association Curation
PMID:31474649 - Identification of 15 New Bypassable Essential Genes of Fission Yeast.
Takeda A et al. Cell Struct Funct 2019 Sep 27;44(2):113-119
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:11850415 - Purification and characterization of the Schizosaccharomyces pombe origin recognition complex: interaction with origin DNA and Cdc18 protein.
Chuang RY et al. J Biol Chem 2002 May 10;277(19):16920-7
PMID:11689699 - Site-specific DNA binding of the Schizosaccharomyces pombe origin recognition complex is determined by the Orc4 subunit.
Kong D et al. Mol Cell Biol 2001 Dec;21(23):8095-103
PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.
Egan ED et al. RNA 2014 Jun;20(6):867-81
PMID:11717425 - The Schizosaccharomyces pombe origin recognition complex interacts with multiple AT-rich regions of the replication origin DNA by means of the AT-hook domains of the spOrc4 protein.
Lee JK et al. Proc Natl Acad Sci U S A 2001 Nov 20;98(24):13589-94