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protein coding gene - rep1 (SPBC2D10.06) - MBF transcription factor activator Rep1

Gene summary

Standard name
rep1
Systematic ID
SPBC2D10.06
Product
MBF transcription factor activator Rep1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
rec16
UniProt ID
P40379
ORFeome ID
40/40E08
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 2976698..2978838 forward strand

Annotation

Comment

PBO:0000206 - deletion mutant expression profiling

References:

GO biological process

GO:0006357 - regulation of transcription by RNA polymerase II

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GO cellular component

GO:0005634 - nucleus

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GO molecular function

GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding

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GO:0003713 - transcription coactivator activity

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Modification

MOD:00046 - O-phospho-L-serine

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MOD:00047 - O-phospho-L-threonine

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Multi-locus phenotype

FYPO:0000474 - abolished meiosis

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Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0002173 - increased level of meiotic gene mRNA during vegetative growth

References:

Genotypes:

Protein features

PBO:0111745 - zf-C2H2 type

PBO:0111743 - zinc finger protein

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0002736 - abnormal mitotic cell cycle phase

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Genotypes:

FYPO:0000117 - abnormal septum assembly

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Genotypes:

FYPO:0003066 - abnormal sporulation resulting in formation of ascus with fewer than four spores

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Genotypes:

FYPO:0002044 - abolished premeiotic DNA replication

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Genotypes:

FYPO:0000046 - decreased cell population growth

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Genotypes:

FYPO:0000476 - decreased frequency of meiosis

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Genotypes:

FYPO:0003179 - decreased intragenic meiotic recombination

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Genotypes:

FYPO:0005121 - decreased level of early meiotic gene mRNA during meiotic cell cycle

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Genotypes:

FYPO:0002959 - decreased RNA level during meiosis

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Genotypes:

FYPO:0004630 - decreased RNA level during meiotic cell cycle

References:

Genotypes:

FYPO:0000581 - decreased spore germination frequency

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Genotypes:

FYPO:0000584 - decreased sporulation frequency

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Genotypes:

FYPO:0004628 - delayed onset of premeiotic DNA replication

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Genotypes:

FYPO:0005125 - increased level of nitrogen starvation gene mRNA during meiotic cell cycle

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Genotypes:

FYPO:0005120 - increased RNA level during meiotic cell cycle

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Genotypes:

FYPO:0004665 - linear elements absent from cell

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Genotypes:

FYPO:0006518 - loss of viability in G0

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Genotypes:

FYPO:0007553 - normal G1 to G0 transition

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Genotypes:

FYPO:0000760 - normal mating

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Genotypes:

FYPO:0004629 - normal mitotic DNA replication

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

FYPO:0009068 - resistance to ciclopirox olamine

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Genotypes:

FYPO:0000764 - resistance to cycloheximide

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Genotypes:

FYPO:0001583 - resistance to lithium

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0005253 - resistance to tamoxifen

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Genotypes:

FYPO:0003372 - RNA absent from cell during meiosis

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Genotypes:

FYPO:0006975 - RNA absent from cell during meiotic cell cycle

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Genotypes:

FYPO:0000799 - sensitive to diamide

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Genotypes:

FYPO:0001492 - viable elongated vegetative cell

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0000110 - orthologs cannot be distinguished

Protein features

IDNameInterPro nameDB name
PS00028ZINC_FINGER_C2H2_1Zf-C2H2_typePROSITE patterns

References / Literature

PMID:10779336 - Fission yeast Eso1p is required for establishing sister chromatid cohesion during S phase.
Tanaka K et al. Mol Cell Biol 2000 May;20(10):3459-69
PMID:25373780 - A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.
Graml V et al. Dev Cell 2014 Oct 27;31(2):227-239
PMID:26628015 - Characterization of Tamoxifen as an Antifungal Agent Using the Yeast Schizosaccharomyces Pombe Model Organism.
Zhang X et al. Kobe J Med Sci 2015 Oct 09;61(2):E54-63
PMID:36794724 - Cellular responses to long-term phosphate starvation of fission yeast: Maf1 determines fate choice between quiescence and death associated with aberrant tRNA biogenesis.
Garg A et al. Nucleic Acids Res 2023 Apr 24;51(7):3094-3115
PMID:11795845 - The role of DSC1 components cdc10+, rep1+ and rep2+ in MCB gene transcription at the mitotic G1-S boundary in fission yeast.
White S et al. Curr Genet 2001 Dec;40(4):251-9
PMID:12665553 - Linear element formation and their role in meiotic sister chromatid cohesion and chromosome pairing.
Molnar M et al. J Cell Sci 2003 May 01;116(Pt 9):1719-31
PMID:30824696 - Systematic analysis reveals the prevalence and principles of bypassable gene essentiality.
Li J et al. Nat Commun 2019 Mar 01;10(1):1002
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:15166138 - A novel gene, msa1, inhibits sexual differentiation in Schizosaccharomyces pombe.
Jeong HT et al. Genetics 2004 May;167(1):77-91
PMID:24957674 - Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.
Anver S et al. EMBO Rep 2014 Aug;15(8):894-902
PMID:33536434 - A scaffold lncRNA shapes the mitosis to meiosis switch.
Andric V et al. Nat Commun 2021 Feb 03;12(1):770
PMID:28765164 - Selective termination of lncRNA transcription promotes heterochromatin silencing and cell differentiation.
Touat-Todeschini L et al. EMBO J 2017 Sep 01;36(17):2626-2641
PMID:35924983 - Genetic-interaction screens uncover novel biological roles and regulators of transcription factors in fission yeast.
Chatfield-Reed K et al. G3 (Bethesda) 2022 Aug 25;12(9)
PMID:9671458 - An RNA binding protein negatively controlling differentiation in fission yeast.
Tsukahara K et al. Mol Cell Biol 1998 Aug;18(8):4488-98
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:9671035 - Global control of meiotic recombination genes by Schizosaccharomyces pombe rec16 (rep1).
Ding R et al. Mol Gen Genet 1998 Jun;258(6):663-70
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:28841135 - Ubiquitination-dependent control of sexual differentiation in fission yeast.
Simonetti F et al. Elife 2017 Aug 25;6
PMID:17927811 - Transcriptional regulatory network for sexual differentiation in fission yeast.
Mata J et al. Genome Biol 2007;8(10):R217
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:14648198 - DSC1-MCB regulation of meiotic transcription in Schizosaccharomyces pombe.
Cunliffe L et al. Mol Genet Genomics 2004 Feb;271(1):60-71
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:23658229 - Red5 and three nuclear pore components are essential for efficient suppression of specific mRNAs during vegetative growth of fission yeast.
Sugiyama T et al. Nucleic Acids Res 2013 Jul;41(13):6674-86
PMID:7588609 - Fission yeast Rep2 is a putative transcriptional activator subunit for the cell cycle 'start' function of Res2-Cdc10.
Nakashima N et al. EMBO J 1995 Oct 02;14(19):4794-802
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:21317872 - Red1 promotes the elimination of meiosis-specific mRNAs in vegetatively growing fission yeast.
Sugiyama T et al. EMBO J 2011 Mar 16;30(6):1027-39
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:26670050 - Regulation of mRNA Levels by Decay-Promoting Introns that Recruit the Exosome Specificity Factor Mmi1.
Kilchert C et al. Cell Rep 2015 Dec 22;13(11):2504-2515
PMID:23695302 - Functional characterization of fission yeast transcription factors by overexpression analysis.
Vachon L et al. Genetics 2013 Aug;194(4):873-84
PMID:9136000 - The Schizosaccharomyces pombe rec16 gene product regulates multiple meiotic events.
Li YF et al. Genetics 1997 May;146(1):57-67
PMID:8168486 - A zinc finger protein controls the onset of premeiotic DNA synthesis of fission yeast in a Mei2-independent cascade.
Sugiyama A et al. EMBO J 1994 Apr 15;13(8):1881-7
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.
Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)