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protein coding gene - rpl802 (SPBC2F12.07c) - 60S ribosomal protein L8/L2

Gene summary

Standard name
rpl802
Systematic ID
SPBC2F12.07c
Product
60S ribosomal protein L8/L2
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
rpl8-2, rpk37, rpk5b
UniProt ID
P0CT71
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 1726665..1727577 forward strand

Annotation

GO biological process

GO:0002181 - cytoplasmic translation

References:

GO cellular component

GO:0022625 - cytosolic large ribosomal subunit

References:

GO molecular function

GO:0019843 - rRNA binding

References:

GO:0003735 - structural constituent of ribosome

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:01148 - ubiquitinylated lysine

References:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0001491 - viable vegetative cell

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF00181Ribosomal_L2_NRibosomal_uL2_RNA-bd_domPfam
PF03947Ribosomal_L2_CRibosomal_uL2_CPfam
PS00467RIBOSOMAL_L2Ribosomal_uL2_CSPROSITE patterns
SM01382Ribosomal_L2_CRibosomal_uL2_CSMART
SM01383Ribosomal_L2Ribosomal_uL2_RNA-bd_domSMART
G3DSA:2.30.30.30:FF:000006CATH-FunFam
G3DSA:2.40.50.140:FF:000020CATH-FunFam
G3DSA:4.10.950.10:FF:000002CATH-FunFam
G3DSA:2.30.30.30Rib_uL2_dom2CATH-Gene3D
G3DSA:2.40.50.140NA-bd_OB-foldCATH-Gene3D
G3DSA:4.10.950.10Ribosomal_uL2_dom3CATH-Gene3D
SSF50104Translation_prot_SH3-like_sfSUPERFAMILY
SSF50249NA-bd_OB-foldSUPERFAMILY
PTHR13691Ribosomal_uL2PANTHER
PIRSF002158Ribosomal_L2Ribosomal_uL2PIRSF

Orthologs

References / Literature

PMID:30321377 - Proteomic profiling and functional characterization of post-translational modifications of the fission yeast RNA exosome.
Telekawa C et al. Nucleic Acids Res 2018 Nov 30;46(21):11169-11183
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:21652630 - Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.
Snaith HA et al. J Cell Sci 2011 Jul 01;124(Pt 13):2187-99
PMID:26152728 - A Two-step Protein Quality Control Pathway for a Misfolded DJ-1 Variant in Fission Yeast.
Mathiassen SG et al. J Biol Chem 2015 Aug 21;290(34):21141-21153
PMID:39358553 - Ageing-associated long non-coding RNA extends lifespan and reduces translation in non-dividing cells.
Anver S et al. EMBO Rep 2024 Oct 02;
PMID:8367312 - The primary sequence of the Schizosaccharomyces pombe protein homologous to S.cerevisiae ribosomal protein L2.
Presutti C et al. Nucleic Acids Res 1993 Aug 11;21(16):3900
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
PMID:27168121 - Discovery of genes involved in mitosis, cell division, cell wall integrity and chromosome segregation through construction of Schizosaccharomyces pombe deletion strains.
Chen JS et al. Yeast 2016 Sep;33(9):507-17
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
GO_REF:0000050 - Manual transfer of GO annotation data to genes by curator judgment of sequence model
PMID:20403971 - Proteomic and functional analysis of the noncanonical poly(A) polymerase Cid14.
Keller C et al. RNA 2010 Jun;16(6):1124-9
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:26896847 - Ensembl comparative genomics resources.
Herrero J et al. Database (Oxford) 2016;2016
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:3029717 - Sequence and regulatory responses of a ribosomal protein gene from the fission yeast Schizosaccharomyces pombe.
Nischt R et al. Nucleic Acids Res 1987 Feb 25;15(4):1477-92
PMID:38051102 - Fission Yeast TORC1 Promotes Cell Proliferation through Sfp1, a Transcription Factor Involved in Ribosome Biogenesis.
Tai YT et al. Mol Cell Biol 2023 Dec 05;:1-18
PMID:2611912 - A ribosomal protein gene family from Schizosaccharomyces pombe consisting of three active members.
Gatermann KB et al. Curr Genet 1989 Dec;16(5-6):361-7