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protein coding gene - atf21 (SPBC2F12.09c) - DNA-binding transcription factor, Atf-CREB family Atf21

Gene summary

Standard name
atf21
Systematic ID
SPBC2F12.09c
Product
DNA-binding transcription factor, Atf-CREB family Atf21
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
P78962
ORFeome ID
32/32D09
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 1723013..1724450 forward strand

Annotation

Comment

PBO:0000206 - deletion mutant expression profiling

References:

GO biological process

GO:0006357 - regulation of transcription by RNA polymerase II

References:

GO:0060905 - regulation of induction of conjugation upon nitrogen starvation

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GO cellular component

GO:0005634 - nucleus

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GO molecular function

GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

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GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding

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Modification

MOD:00046 - O-phospho-L-serine

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MOD:00047 - O-phospho-L-threonine

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Multi-locus phenotype

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0005127 - increased level of late meiotic gene mRNA during vegetative growth

References:

Genotypes:

Protein features

PBO:0111895 - Atf-CREB subfamily

PBO:0111793 - bZIP (basic leucine zipper) transcription factor family

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PomGeneEx:0000011 - RNA level increased

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PomGeneEx:0000013 - RNA level unchanged

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000117 - abnormal septum assembly

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Genotypes:

FYPO:0000121 - abnormal sporulation

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Genotypes:

FYPO:0000046 - decreased cell population growth

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Genotypes:

FYPO:0004750 - elongated septated vegetative cell

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Genotypes:

FYPO:0009072 - increased cell population growth on lysine nitrogen source

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Genotypes:

FYPO:0002664 - increased level of stress responsive gene mRNA during vegetative growth

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Genotypes:

FYPO:0006518 - loss of viability in G0

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Genotypes:

FYPO:0001000 - normal cell cycle arrest in mitotic G1 phase during nitrogen starvation

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Genotypes:

FYPO:0007553 - normal G1 to G0 transition

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Genotypes:

FYPO:0001022 - normal growth during cellular response to high osmolarity

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Genotypes:

FYPO:0001037 - normal growth during cellular response to salt stress

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Genotypes:

FYPO:0001147 - normal mating efficiency

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Genotypes:

FYPO:0002693 - resistance to diamide

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Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0001034 - resistance to tunicamycin

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Genotypes:

FYPO:0006680 - sensitive to bisphenol A

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Genotypes:

FYPO:0007931 - sensitive to egtazic acid

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Genotypes:

FYPO:0003656 - sensitive to vanadate

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Genotypes:

FYPO:0001492 - viable elongated vegetative cell

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0000110 - orthologs cannot be distinguished

Protein features

IDNameInterPro nameDB name
PF00170bZIP_1bZIPPfam
cd14687bZIP_ATF2CDD
PS00036BZIP_BASICbZIPPROSITE patterns
PS50217BZIPbZIPPROSITE profiles
SM00338BRLZbZIPSMART
PR00043LEUZIPPRJUNLeuzip_JunPRINTS
G3DSA:1.20.5.170:FF:000010CATH-FunFam
G3DSA:1.20.5.170CATH-Gene3D
SSF57959bZIP_sfSUPERFAMILY
PTHR19304PANTHER
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder
mobidb-lite-Polardisorder_predictionMobiDB-Polar

Orthologs

References / Literature

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:28388826 - Sulfur restriction extends fission yeast chronological lifespan through Ecl1 family genes by downregulation of ribosome.
Ohtsuka H et al. Mol Microbiol 2017 Jul;105(1):84-97
PMID:35924983 - Genetic-interaction screens uncover novel biological roles and regulators of transcription factors in fission yeast.
Chatfield-Reed K et al. G3 (Bethesda) 2022 Aug 25;12(9)
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:17927811 - Transcriptional regulatory network for sexual differentiation in fission yeast.
Mata J et al. Genome Biol 2007;8(10):R217
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:39105351 - A novel transcription factor Sdr1 involving sulfur depletion response in fission yeast.
Ohtsuka H et al. Genes Cells 2024 Aug;29(8):667-680
PMID:28357272 - A central role for TOR signalling in a yeast model for juvenile CLN3 disease.
Bond ME et al. Microb Cell 2015 Nov 11;2(12):466-480
PMID:10102365 - Isolation of multicopy suppressors of the calcium sensitivity of a mutant lacking the bZIP transcription factor Atf1 in fission yeast.
Ohmiya R et al. Mol Gen Genet 1999 Mar;261(2):297-306
PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.
Blyth J et al. Genetics 2018 Feb;208(2):589-603
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
Paulo JA et al. J Proteomics 2020 Jan 06;210:103531
PMID:22910366 - Organellar mechanosensitive channels in fission yeast regulate the hypo-osmotic shock response.
Nakayama Y et al. Nat Commun 2012;3:1020
PMID:12529438 - Global transcriptional responses of fission yeast to environmental stress.
Chen D et al. Mol Biol Cell 2003 Jan;14(1):214-29
PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.
Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838
PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.
Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)
PMID:36794724 - Cellular responses to long-term phosphate starvation of fission yeast: Maf1 determines fate choice between quiescence and death associated with aberrant tRNA biogenesis.
Garg A et al. Nucleic Acids Res 2023 Apr 24;51(7):3094-3115
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:23695302 - Functional characterization of fission yeast transcription factors by overexpression analysis.
Vachon L et al. Genetics 2013 Aug;194(4):873-84
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:8824587 - Conjugation, meiosis, and the osmotic stress response are regulated by Spc1 kinase through Atf1 transcription factor in fission yeast.
Shiozaki K et al. Genes Dev 1996 Sep 15;10(18):2276-88
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.
Rallis C et al. Sci Rep 2017 Mar 10;7:44257
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.
Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
PMID:30647105 - Comparative Genomic Screen in Two Yeasts Reveals Conserved Pathways in the Response Network to Phenol Stress.
Alhoch B et al. G3 (Bethesda) 2019 Mar 07;9(3):639-650