protein coding gene - rep2 (SPBC2F12.11c) - MBF transcription factor activator Rep2

Gene summary

Standard name

rep2

Systematic ID

SPBC2F12.11c

Product

MBF transcription factor activator Rep2

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

Q09824

ORFeome ID

40/40A03

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 1717703..1719322 forward strand

Annotation

Orthologs

• rep2 (SJAG_01728) Schizosaccharomyces japonicus

References / Literature

PMID:30824696 - Systematic analysis reveals the prevalence and principles of bypassable gene essentiality.

Li J et al. Nat Commun 2019 Mar 01;10(1):1002

PMID:23173672 - Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.

Pan X et al. BMC Genomics 2012 Nov 23;13:662

PMID:10982385 - A pcl-like cyclin activates the Res2p-Cdc10p cell cycle "start" transcriptional factor complex in fission yeast.

Tanaka K et al. Mol Biol Cell 2000 Sep;11(9):2845-62

PMID:25373780 - A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.

Graml V et al. Dev Cell 2014 Oct 27;31(2):227-239

PMID:21760946 - Identification of genes affecting the toxicity of anti-cancer drug bortezomib by genome-wide screening in S. pombe.

Takeda K et al. PLoS One 2011;6(7):e22021

PMID:8970158 - Domains determining the functional distinction of the fission yeast cell cycle "start" molecules Res1 and Res2.

Sturm S et al. Mol Biol Cell 1996 Dec;7(12):1967-76

PMID:11029045 - A role for the START gene-specific transcription factor complex in the inactivation of cyclin B and Cut2 destruction.

Tournier S et al. Mol Biol Cell 2000 Oct;11(10):3411-24

PMID:21504829 - Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Stewart EV et al. Mol Cell 2011 Apr 22;42(2):160-71

PMID:14648198 - DSC1-MCB regulation of meiotic transcription in Schizosaccharomyces pombe.

Cunliffe L et al. Mol Genet Genomics 2004 Feb;271(1):60-71

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:24957674 - Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

Anver S et al. EMBO Rep 2014 Aug;15(8):894-902

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160

PMID:36478272 - Translation-complex profiling of fission yeast cells reveals dynamic rearrangements of scanning ribosomal subunits upon nutritional stress.

Duncan CDS et al. Nucleic Acids Res 2022 Dec 09;50(22):13011-13025

PMID:9614195 - Functional domains of rep2, a transcriptional activator subunit for Res2-Cdc10, controlling the cell cycle "start".

Tahara S et al. Mol Biol Cell 1998 Jun;9(6):1577-88

PMID:20537132 - Global fitness profiling of fission yeast deletion strains by barcode sequencing.

Han TX et al. Genome Biol 2010;11(6):R60

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:32435206 - Posttranslational Arginylation Enzyme Arginyltransferase1 Shows Genetic Interactions With Specific Cellular Pathways in vivo .

Wiley DJ et al. Front Physiol 2020;11:427

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:7588609 - Fission yeast Rep2 is a putative transcriptional activator subunit for the cell cycle 'start' function of Res2-Cdc10.

Nakashima N et al. EMBO J 1995 Oct 02;14(19):4794-802

PMID:22252817 - A genomewide screen in Schizosaccharomyces pombe for genes affecting the sensitivity of antifungal drugs that target ergosterol biosynthesis.

Fang Y et al. Antimicrob Agents Chemother 2012 Apr;56(4):1949-59

PMID:30257894 - mmi1 and rep2 mRNAs are novel RNA targets of the Mei2 RNA-binding protein during early meiosis in Schizosaccharomyces pombe .

Mukherjee K et al. Open Biol 2018 Sep 26;8(9)

PMID:25076038 - Large scale screening of genetic interaction with sgf73(+) in fission yeast.

Guo Y et al. Yi Chuan 2014 Jul;36(7):723-31

PMID:24463365 - Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growth.

Rallis C et al. Biol Open 2014 Feb 15;3(2):161-71

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:11389847 - Transcriptional termination factors for RNA polymerase II in yeast.

Aranda A et al. Mol Cell 2001 May;7(5):1003-11

PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.

Blyth J et al. Genetics 2018 Feb;208(2):589-603

PMID:26890608 - A functional genome-wide genetic screening identifies new pathways controlling the G1/S transcriptional wave.

Gaspa L et al. Cell Cycle 2016;15(5):720-9

PMID:31260531 - Gcn5-mediated acetylation at MBF-regulated promoters induces the G1/S transcriptional wave.

González-Medina A et al. Nucleic Acids Res 2019 Sep 19;47(16):8439-8451

PMID:30134042 - The INO80 complex activates the transcription of S-phase genes in a cell cycle-regulated manner.

Knezevic I et al. FEBS J 2018 Oct;285(20):3870-3881

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:9303312 - Control of S-phase periodic transcription in the fission yeast mitotic cycle.

Baum B et al. EMBO J 1997 Aug 01;16(15):4676-88

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323