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protein coding gene - crs1 (SPBC2G2.09c) - meiosis specific cyclin Crs1

Gene summary

Standard name
crs1
Systematic ID
SPBC2G2.09c
Product
meiosis specific cyclin Crs1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
mug17
UniProt ID
O43008
ORFeome ID
10/10F06
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 3452323..3453516 reverse strand

Annotation

Comment

PBO:0091288 - meiosis specific splicing

References:

GO biological process

GO:0000082 - G1/S transition of mitotic cell cycle

References:

GO:1905263 - positive regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination

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GO:1901993 - regulation of meiotic cell cycle phase transition

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GO:0023052 - signaling

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GO cellular component

GO:0000307 - cyclin-dependent protein kinase holoenzyme complex

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GO:0005829 - cytosol

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GO:0035974 - meiotic spindle pole body

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GO:0005654 - nucleoplasm

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GO:0005634 - nucleus

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GO molecular function

GO:0016538 - cyclin-dependent protein serine/threonine kinase regulator activity

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Modification

MOD:00046 - O-phospho-L-serine

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Multi-locus phenotype

FYPO:0006838 - abnormal linear element maturation

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Genotypes:

FYPO:0001370 - abnormal protein localization

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Genotypes:

FYPO:0004608 - abnormal spindle pole body morphology during meiosis II

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Genotypes:

FYPO:0003066 - abnormal sporulation resulting in formation of ascus with fewer than four spores

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Genotypes:

FYPO:0003263 - abnormal sporulation resulting in formation of ascus with more than four spores

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Genotypes:

FYPO:0004077 - abnormal sporulation resulting in formation of ascus with single large spore

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Genotypes:

FYPO:0004760 - abnormal sporulation resulting in formation of azygotic ascus with more than four spores

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Genotypes:

FYPO:0000681 - abnormal sporulation resulting in formation of two-spore ascus

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Genotypes:

FYPO:0004800 - abolished premeiotic DNA replication during azygotic meiotic cell cycle

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Genotypes:

FYPO:0002485 - decreased intergenic meiotic recombination

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Genotypes:

FYPO:0003179 - decreased intragenic meiotic recombination

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Genotypes:

FYPO:0003615 - decreased meiotic DNA double-strand break formation

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Genotypes:

FYPO:0004801 - delayed onset of premeiotic DNA replication during azygotic meiosis

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Genotypes:

FYPO:0002151 - inviable spore

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Genotypes:

FYPO:0000478 - normal meiosis

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Genotypes:

FYPO:0005650 - normal onset of premeiotic DNA replication

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Genotypes:

FYPO:0004993 - normal spore germination frequency

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Genotypes:

Protein features

PBO:0111794 - cyclin

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0003066 - abnormal sporulation resulting in formation of ascus with fewer than four spores

References:

Genotypes:

FYPO:0004605 - decreased distance travelled by the spindle pole body during horsetail movement

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Genotypes:

FYPO:0002485 - decreased intergenic meiotic recombination

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Genotypes:

FYPO:0003179 - decreased intragenic meiotic recombination

References:

Genotypes:

FYPO:0003615 - decreased meiotic DNA double-strand break formation

References:

Genotypes:

FYPO:0008314 - normal initial meiotic spindle pole body separation in meiosis I

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Genotypes:

FYPO:0008313 - normal meiotic spindle pole body insertion into nuclear envelope in meiosis I

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Genotypes:

FYPO:0005650 - normal onset of premeiotic DNA replication

References:

Genotypes:

FYPO:0002043 - normal premeiotic DNA replication

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Genotypes:

FYPO:0004993 - normal spore germination frequency

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Genotypes:

FYPO:0001103 - resistance to hydrogen peroxide

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0001034 - resistance to tunicamycin

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Genotypes:

FYPO:0008310 - unstable meiotic telomere clustering

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0000110 - orthologs cannot be distinguished

Warnings

PBO:0000070 - gene structure updated

References:

Protein features

IDNameInterPro nameDB name
PF00134Cyclin_NCyclin_NPfam
SM00385CYCLINCyclin-like_domSMART
G3DSA:1.10.472.10CATH-Gene3D
SSF47954Cyclin-like_sfSUPERFAMILY

Orthologs

References / Literature

PMID:15893732 - Negative control contributes to an extensive program of meiotic splicing in fission yeast.
Averbeck N et al. Mol Cell 2005 May 13;18(4):491-8
GO_REF:0000051 - S. pombe keyword mapping
PMID:21317872 - Red1 promotes the elimination of meiosis-specific mRNAs in vegetatively growing fission yeast.
Sugiyama T et al. EMBO J 2011 Mar 16;30(6):1027-39
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:16823445 - Selective elimination of messenger RNA prevents an incidence of untimely meiosis.
Harigaya Y et al. Nature 2006 Jul 06;442(7098):45-50
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:22474355 - Heterochromatin protein 1 homologue Swi6 acts in concert with Ers1 to regulate RNAi-directed heterochromatin assembly.
Hayashi A et al. Proc Natl Acad Sci U S A 2012 Apr 17;109(16):6159-64
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:30640914 - CDK contribution to DSB formation and recombination in fission yeast meiosis.
Bustamante-Jaramillo LF et al. PLoS Genet 2019 Jan;15(1):e1007876
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:28841135 - Ubiquitination-dependent control of sexual differentiation in fission yeast.
Simonetti F et al. Elife 2017 Aug 25;6
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.
Egan ED et al. RNA 2014 Jun;20(6):867-81
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:28199302 - Untimely expression of gametogenic genes in vegetative cells causes uniparental disomy.
Folco HD et al. Nature 2017 Mar 02;543(7643):126-130
PMID:16615890 - Meiotic proteins bqt1 and bqt2 tether telomeres to form the bouquet arrangement of chromosomes.
Chikashige Y et al. Cell 2006 Apr 07;125(1):59-69
PMID:34067465 - The Meiosis-Specific Crs1 Cyclin Is Required for Efficient S-Phase Progression and Stable Nuclear Architecture.
Bustamante-Jaramillo LF et al. Int J Mol Sci 2021 May 22;22(11)
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:25891897 - A single cyclin-CDK complex is sufficient for both mitotic and meiotic progression in fission yeast.
Gutiérrez-Escribano P et al. Nat Commun 2015 Apr 20;6:6871
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:23658229 - Red5 and three nuclear pore components are essential for efficient suppression of specific mRNAs during vegetative growth of fission yeast.
Sugiyama T et al. Nucleic Acids Res 2013 Jul;41(13):6674-86
PMID:26670050 - Regulation of mRNA Levels by Decay-Promoting Introns that Recruit the Exosome Specificity Factor Mmi1.
Kilchert C et al. Cell Rep 2015 Dec 22;13(11):2504-2515
PMID:28765164 - Selective termination of lncRNA transcription promotes heterochromatin silencing and cell differentiation.
Touat-Todeschini L et al. EMBO J 2017 Sep 01;36(17):2626-2641
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:16303567 - A large-scale screen in S. pombe identifies seven novel genes required for critical meiotic events.
Martín-Castellanos C et al. Curr Biol 2005 Nov 22;15(22):2056-62