PomBase home

protein coding gene - mrm2 (SPBC2G2.15c) - mitochondrial 2' O-ribose methyltransferase Mrm2

Gene summary

Standard name
mrm2
Systematic ID
SPBC2G2.15c
Product
mitochondrial 2' O-ribose methyltransferase Mrm2
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
P78860
ORFeome ID
10/10G09
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 3462585..3464069 reverse strand

Annotation

Disease association

MONDO:0018158 - mitochondrial DNA depletion syndrome

References:

MONDO:0032815 - mitochondrial DNA depletion syndrome 17

References:

GO biological process

GO:1902775 - mitochondrial large ribosomal subunit assembly

References:

GO:0031167 - rRNA methylation

References:

GO cellular component

GO:0005759 - mitochondrial matrix

References:

GO:0005739 - mitochondrion

References:

GO molecular function

GO:0008650 - rRNA (uridine-2'-O-ribose)-methyltransferase activity

References:

Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

References:

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0009094 - increased cell population growth on lysine and proline nitrogen source

References:

Genotypes:

FYPO:0002693 - resistance to diamide

References:

Genotypes:

FYPO:0009038 - resistance to egtazic acid

References:

Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0004325 - sensitive to 5-fluorouracil

References:

Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

References:

Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF01728FtsJRNA_MeTrfase_FtsJ_domPFAM
G3DSA:3.40.50.150:FF:000005FUNFAM
SSF53335S-adenosyl-L-methionine-dependent methyltransferasesSAM-dependent_MTases_sfSUPERFAMILY
G3DSA:3.40.50.150Vaccinia Virus protein VP39SAM-dependent_MTases_sfGENE3D
PTHR10920RIBOSOMAL RNA METHYLTRANSFERASERNA_methyltr_RlmEPANTHER
PIRSF00546123S_rRNA_mtaserRNA-MeTfrase_EPIRSF
MF_01547RNA_methyltr_ErRNA-MeTfrase_EHAMAP

Orthologs

References / Literature

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:32282918 - Genetic interactions and transcriptomics implicate fission yeast CTD prolyl isomerase Pin1 as an agent of RNA 3' processing and transcription termination that functions via its effects on CTD phosphatase Ssu72.
Sanchez AM et al. Nucleic Acids Res 2020 May 21;48(9):4811-4826
PB_REF:0000003 - Disease Association Curation
PMID:24223771 - New insights into the RNA-based mechanism of action of the anticancer drug 5'-fluorouracil in eukaryotic cells.
Mojardín L et al. PLoS One 2013;8(11):e78172
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
GO_REF:0000033 - Annotation inferences using phylogenetic trees
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:27255861 - Genetic evidence for involvement of membrane trafficking in the action of 5-fluorouracil.
Hu L et al. Fungal Genet Biol 2016 Aug;93:17-24
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623