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protein coding gene - mpi1 (SPBC2G2.16) - mannose-6-phosphate isomerase Mpi1

Gene summary

Standard name
mpi1
Systematic ID
SPBC2G2.16
Product
mannose-6-phosphate isomerase Mpi1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O43014
ORFeome ID
22/22C11
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 3464820..3466309 forward strand

Annotation

PBO:0004524 - 5.3.1.8

Disease association

MONDO:0015286 - congenital disorder of glycosylation

References:

MONDO:0005066 - metabolic disease

References:

MONDO:0011257 - MPI-congenital disorder of glycosylation

References:

GO biological process

GO:0009298 - GDP-mannose biosynthetic process

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0005634 - nucleus

References:

GO molecular function

GO:0004476 - mannose-6-phosphate isomerase activity

References:

GO:0008270 - zinc ion binding

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:01148 - ubiquitinylated lysine

References:

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF01238PMI_typeI_CPMI_typeI_CPfam
PF20511PMI_typeI_catPMI_typeI_catPfam
PF20512PMI_typeI_helPMI_typeI_helPfam
cd07011cupin_PMI_type_I_NCDD
PS00965PMI_I_1Pmannose_isomerase-type1_CSPROSITE patterns
PR00714MAN6PISMRASEMannose-6-P_IsomerasePRINTS
G3DSA:1.10.441.10:FF:000003CATH-FunFam
G3DSA:1.10.441.10CATH-Gene3D
G3DSA:2.60.120.10RmlC-like_jellyrollCATH-Gene3D
SSF51182RmlC_Cupin_sfSUPERFAMILY
PTHR10309Mannose-6-P_IsomerasePANTHER
PIRSF001480Mannose-6-phosphate_isomeraseMannose-6-P_IsomerasePIRSF
TIGR00218manAMan6P_Isoase-1NCBIFAM

Orthologs

References / Literature

GO_REF:0000033 - Annotation inferences using phylogenetic trees
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
GO_REF:0000002 - Comments
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PB_REF:0000003 - Disease Association Curation