protein coding gene - ctu1 (SPBC2G5.03) - cytosolic tRNA-uridine 2-sulfurtransferase subunit Ctu1

Gene summary

Standard name

ctu1

Systematic ID

SPBC2G5.03

Product

cytosolic tRNA-uridine 2-sulfurtransferase subunit Ctu1

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

O94282

ORFeome ID

14/14H09

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 2581935..2583104 forward strand

Annotation

Protein features

Orthologs

• CTU1 (HGNC:29590) Homo sapiens
• ctu1 (SJAG_03932) Schizosaccharomyces japonicus
• NCS6 (YGL211W) Saccharomyces cerevisiae

References / Literature

PMID:18391219 - The conserved Wobble uridine tRNA thiolase Ctu1-Ctu2 is required to maintain genome integrity.

Dewez M et al. Proc Natl Acad Sci U S A 2008 Apr 08;105(14):5459-64

PMID:23874237 - Modification of tRNA(Lys) UUU by elongator is essential for efficient translation of stress mRNAs.

Fernández-Vázquez J et al. PLoS Genet 2013;9(7):e1003647

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:23163955 - Analysis of stress-induced duplex destabilization (SIDD) properties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe.

Yadav MP et al. BMC Res Notes 2012 Nov 19;5:643

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:24223771 - New insights into the RNA-based mechanism of action of the anticancer drug 5'-fluorouracil in eukaryotic cells.

Mojardín L et al. PLoS One 2013;8(11):e78172

PMID:30355493 - Expanded Interactome of the Intrinsically Disordered Protein Dss1.

Schenstrøm SM et al. Cell Rep 2018 Oct 23;25(4):862-870

PMID:25651869 - Chemical genomics approach to identify genes associated with sensitivity to rapamycin in the fission yeast Schizosaccharomyces pombe.

Doi A et al. Genes Cells 2015 Apr;20(4):292-309

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160

PMID:18931302 - Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes.

Dixon SJ et al. Proc Natl Acad Sci U S A 2008 Oct 28;105(43):16653-8

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:18684775 - A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe.

Kennedy PJ et al. Toxicol Sci 2008 Nov;106(1):124-39

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:21504829 - Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Stewart EV et al. Mol Cell 2011 Apr 22;42(2):160-71

PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.

Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684

PMID:22768388 - Translational control of cell division by Elongator.

Bauer F et al. Cell Rep 2012 May 31;1(5):424-33

PMID:27255861 - Genetic evidence for involvement of membrane trafficking in the action of 5-fluorouracil.

Hu L et al. Fungal Genet Biol 2016 Aug;93:17-24

PMID:31064814 - Proximity-dependent biotinylation mediated by TurboID to identify protein-protein interaction networks in yeast.

Larochelle M et al. J Cell Sci 2019 May 31;132(11)

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:24463365 - Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growth.

Rallis C et al. Biol Open 2014 Feb 15;3(2):161-71