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protein coding gene - kap109 (SPBC30B4.05) - karyopherin/importin beta family nuclear export signal receptor Kap109

Gene summary

Standard name
kap109
Systematic ID
SPBC30B4.05
Product
karyopherin/importin beta family nuclear export signal receptor Kap109
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O13671
ORFeome ID
47/47E12
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 1313207..1316375 forward strand

Annotation

GO biological process

GO:0006611 - protein export from nucleus

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GO cellular component

GO:0005829 - cytosol

References:

GO:0005635 - nuclear envelope

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GO:0034399 - nuclear periphery

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GO molecular function

GO:0005525 - GTP binding

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GO:0005049 - nuclear export signal receptor activity

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GO:0031267 - small GTPase binding

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Modification

MOD:00047 - O-phospho-L-threonine

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Protein features

PBO:0111765 - HEAT repeat

PBO:0111795 - importin family

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

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Genotypes:

FYPO:0004114 - inviable after spore germination, without cell division, abnormal septum morphology

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0003358 - sensitive to miconazole

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Genotypes:

FYPO:0003612 - viable spore population

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF03378CAS_CSE1XPO2_CPFAM
PF03810IBN_NImportin-beta_NPFAM
PF08506Cse1XPO2_centralPFAM
PS50166IMPORTIN_B_NTImportin-beta_NPROSITE_PROFILES
SM00913IBN_N_2Importin-beta_NSMART
G3DSA:1.25.10.10:FF:000057FUNFAM
SSF48371ARM repeatARM-type_foldSUPERFAMILY
G3DSA:1.25.10.10ARM-likeGENE3D
PTHR10997IMPORTIN-7, 8, 11PANTHER

Orthologs

References / Literature

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:19371376 - Schizosaccharomyces pombe cell division cycle under limited glucose requires Ssp1 kinase, the putative CaMKK, and Sds23, a PP2A-related phosphatase inhibitor.
Hanyu Y et al. Genes Cells 2009 May;14(5):539-54
GO_REF:0000051 - S. pombe keyword mapping
PMID:23163955 - Analysis of stress-induced duplex destabilization (SIDD) properties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe.
Yadav MP et al. BMC Res Notes 2012 Nov 19;5:643
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:21340088 - Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.
Arita Y et al. Mol Biosyst 2011 May;7(5):1463-72
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
GO_REF:0000002 - Comments
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:15116432 - Identification of genes encoding putative nucleoporins and transport factors in the fission yeast Schizosaccharomyces pombe: a deletion analysis.
Chen XQ et al. Yeast 2004 Apr 30;21(6):495-509
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:10759889 - Large-scale screening of intracellular protein localization in living fission yeast cells by the use of a GFP-fusion genomic DNA library.
Ding DQ et al. Genes Cells 2000 Mar;5(3):169-90
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323