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protein coding gene - tfb4 (SPBC30B4.07c) - transcription factor TFIIH complex subunit Tfb4

Gene summary

Standard name
tfb4
Systematic ID
SPBC30B4.07c
Product
transcription factor TFIIH complex subunit Tfb4
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O74366
ORFeome ID
13/13E03
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 1319070..1320576 reverse strand

Annotation

GO biological process

GO:0006289 - nucleotide-excision repair

References:

GO:0006367 - transcription initiation at RNA polymerase II promoter

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0005634 - nucleus

References:

GO:0000439 - transcription factor TFIIH core complex

References:

GO:0005675 - transcription factor TFIIH holo complex

References:

GO molecular function

GO:0016251 - RNA polymerase II general transcription initiation factor activity

References:

Protein features

PBO:0111777 - zf-CCCH type

PBO:0111743 - zinc finger protein

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0006926 - increased nucleus:cytoplasm ratio

References:

Genotypes:

FYPO:0002170 - inviable after spore germination, multiple cell divisions, branched, elongated cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF03850Tfb4TFIIH_Tfb4/GTF2H3Pfam
G3DSA:3.40.50.410vWFA_dom_sfCATH-Gene3D
PTHR12831TFIIH_Tfb4/GTF2H3PANTHER
TIGR00627tfb4TFIIH_Tfb4/GTF2H3NCBIFAM

Orthologs

References / Literature

PMID:29084823 - Phosphorylation of the RNA-binding protein Zfs1 modulates sexual differentiation in fission yeast.
Navarro FJ et al. J Cell Sci 2017 Dec 15;130(24):4144-4154
PMID:14534314 - Mediator influences Schizosaccharomyces pombe RNA polymerase II-dependent transcription in vitro.
Spahr H et al. J Biol Chem 2003 Dec 19;278(51):51301-6
PMID:8303296 - RNA polymerase II initiation factor interactions and transcription start site selection.
Li Y et al. Science 1994 Feb 11;263(5148):805-7
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:30759079 - A systematic genetic screen identifies essential factors involved in nuclear size control.
Cantwell H et al. PLoS Genet 2019 Feb;15(2):e1007929
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:22907753 - Posttranscriptional regulation of cell-cell interaction protein-encoding transcripts by Zfs1p in Schizosaccharomyces pombe.
Wells ML et al. Mol Cell Biol 2012 Oct;32(20):4206-14