protein coding gene - swi3 (SPBC30D10.04) - replication fork protection complex subunit Swi3

Gene summary

Standard name

swi3

Systematic ID

SPBC30D10.04

Product

replication fork protection complex subunit Swi3

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

O14350

ORFeome ID

03/03H05

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 3090859..3091856 reverse strand

Annotation

Protein features

Orthologs

• TIPIN (HGNC:30750) Homo sapiens
• swi3 (SJAG_03097) Schizosaccharomyces japonicus
• CSM3 (YMR048W) Saccharomyces cerevisiae

References / Literature

PMID:20537132 - Global fitness profiling of fission yeast deletion strains by barcode sequencing.

Han TX et al. Genome Biol 2010;11(6):R60

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:29852001 - New insights into donor directionality of mating-type switching in Schizosaccharomyces pombe.

Maki T et al. PLoS Genet 2018 May;14(5):e1007424

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:18723894 - Rtf1-mediated eukaryotic site-specific replication termination.

Eydmann T et al. Genetics 2008 Sep;180(1):27-39

PMID:15059961 - RNase-sensitive DNA modification(s) initiates S. pombe mating-type switching.

Vengrova S et al. Genes Dev 2004 Apr 01;18(7):794-804

PMID:26201080 - The DNA-Binding Domain of S. pombe Mrc1 (Claspin) Acts to Enhance Stalling at Replication Barriers.

Zech J et al. PLoS One 2015;10(7):e0132595

PMID:39094570 - A replisome-associated histone H3-H4 chaperone required for epigenetic inheritance.

Yu J et al. Cell 2024 Sep 05;187(18):5010-5028.e24

PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.

Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7

PMID:19264558 - Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.

Deshpande GP et al. DNA Repair (Amst) 2009 May 01;8(5):672-9

PMID:20967229 - Checkpoint-dependent and -independent roles of Swi3 in replication fork recovery and sister chromatid cohesion in fission yeast.

Rapp JB et al. PLoS One 2010 Oct 12;5(10):e13379

PMID:18667534 - Activation of the DNA damage checkpoint in mutants defective in DNA replication initiation.

Yin L et al. Mol Biol Cell 2008 Oct;19(10):4374-82

PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134

PMID:27172183 - Interconnections Between RNA-Processing Pathways Revealed by a Sequencing-Based Genetic Screen for Pre-mRNA Splicing Mutants in Fission Yeast.

Larson A et al. G3 (Bethesda) 2016 Jun 01;6(6):1513-23

PMID:28228545 - Ablation of RNA interference and retrotransposons accompany acquisition and evolution of transposases to heterochromatin protein CENPB.

Upadhyay U et al. Mol Biol Cell 2017 Apr 15;28(8):1132-1146

PMID:25795664 - Genetic Interaction Landscape Reveals Critical Requirements for Schizosaccharomyces pombe Brc1 in DNA Damage Response Mutants.

Sánchez A et al. G3 (Bethesda) 2015 Mar 19;5(5):953-62

PMID:20885790 - Critical functions of Rpa3/Ssb3 in S-phase DNA damage responses in fission yeast.

Cavero S et al. PLoS Genet 2010 Sep 23;6(9):e1001138

PMID:18931302 - Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes.

Dixon SJ et al. Proc Natl Acad Sci U S A 2008 Oct 28;105(43):16653-8

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:24875629 - Essential domains of Schizosaccharomyces pombe Rad8 required for DNA damage response.

Ding L et al. G3 (Bethesda) 2014 May 28;4(8):1373-84

PMID:25483073 - Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.

Mojardín L et al. Cell Cycle 2015;14(2):206-18

PMID:39094566 - Mrc1 regulates parental histone segregation and heterochromatin inheritance.

Toda T et al. Mol Cell 2024 Jul 23;

PMID:23050226 - A genetic screen to discover pathways affecting cohesin function in Schizosaccharomyces pombe identifies chromatin effectors.

Chen Z et al. G3 (Bethesda) 2012 Oct;2(10):1161-8

PMID:12840005 - Complex mechanism of site-specific DNA replication termination in fission yeast.

Codlin S et al. EMBO J 2003 Jul 01;22(13):3431-40

PMID:24189946 - Gene activation by copy transposition in mating-type switching of a homothallic fission yeast.

Egel R et al. Curr Genet 1981 Apr;3(1):5-12

PMID:30824696 - Systematic analysis reveals the prevalence and principles of bypassable gene essentiality.

Li J et al. Nat Commun 2019 Mar 01;10(1):1002

PMID:6587363 - Genes required for initiation and resolution steps of mating-type switching in fission yeast.

Egel R et al. Proc Natl Acad Sci U S A 1984 Jun;81(11):3481-5

PMID:24719968 - Switching genes in Schizosaccharomyces pombe.

Gutz H et al. Curr Genet 1985;9(5):325-31

PMID:27473316 - Characterization of a Novel MMS-Sensitive Allele of Schizosaccharomyces pombe mcm4.

Ranatunga NS et al. G3 (Bethesda) 2016 Oct 13;6(10):3049-3063

PMID:18045993 - RFCCtf18 and the Swi1-Swi3 complex function in separate and redundant pathways required for the stabilization of replication forks to facilitate sister chromatid cohesion in Schizosaccharomyces pombe.

Ansbach AB et al. Mol Biol Cell 2008 Feb;19(2):595-607

PMID:17151242 - Sap1 promotes the association of the replication fork protection complex with chromatin and is involved in the replication checkpoint in Schizosaccharomyces pombe.

Noguchi C et al. Genetics 2007 Feb;175(2):553-66

PMID:25965521 - Ku stabilizes replication forks in the absence of Brc1.

Sánchez A et al. PLoS One 2015;10(5):e0126598

PMID:22952839 - Swi1 associates with chromatin through the DDT domain and recruits Swi3 to preserve genomic integrity.

Noguchi C et al. PLoS One 2012;7(8):e43988

GO_REF:0000002 - Comments

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:26990647 - Swi1Timeless Prevents Repeat Instability at Fission Yeast Telomeres.

Gadaleta MC et al. PLoS Genet 2016 Mar;12(3):e1005943

PMID:17660542 - Mms22 preserves genomic integrity during DNA replication in Schizosaccharomyces pombe.

Dovey CL et al. Genetics 2007 Sep;177(1):47-61

PMID:20924116 - Fission yeast Swi1-Swi3 complex facilitates DNA binding of Mrc1.

Tanaka T et al. J Biol Chem 2010 Dec 17;285(51):39609-22

PMID:30759238 - Role of Cdc23/Mcm10 in generating the ribonucleotide imprint at the mat1 locus in fission yeast.

Singh B et al. Nucleic Acids Res 2019 Apr 23;47(7):3422-3433

PMID:15367656 - Swi1 and Swi3 are components of a replication fork protection complex in fission yeast.

Noguchi E et al. Mol Cell Biol 2004 Oct;24(19):8342-55

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:21760946 - Identification of genes affecting the toxicity of anti-cancer drug bortezomib by genome-wide screening in S. pombe.

Takeda K et al. PLoS One 2011;6(7):e22021

UniProtKB:Q6IUU5 - Unknown title

PMID:1620099 - The switching gene swi6 affects recombination and gene expression in the mating-type region of Schizosaccharomyces pombe.

Lorentz A et al. Mol Gen Genet 1992 Jun;233(3):436-42

PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.

Roguev A et al. Science 2008 Oct 17;322(5900):405-10

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.

Blyth J et al. Genetics 2018 Feb;208(2):589-603

PMID:30104346 - Mre11 complex links sister chromatids to promote repair of a collapsed replication fork.

Zhu M et al. Proc Natl Acad Sci U S A 2018 Aug 28;115(35):8793-8798

PMID:20176980 - Fission yeast Hsk1 (Cdc7) kinase is required after replication initiation for induced mutagenesis and proper response to DNA alkylation damage.

Dolan WP et al. Genetics 2010 May;185(1):39-53

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.

Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)

PMID:19422421 - Interactions between Swi1-Swi3, Mrc1 and S phase kinase, Hsk1 may regulate cellular responses to stalled replication forks in fission yeast.

Shimmoto M et al. Genes Cells 2009 Jun;14(6):669-82

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:30148840 - Tdp1 processes chromate-induced single-strand DNA breaks that collapse replication forks.

Ganguly A et al. PLoS Genet 2018 Aug;14(8):e1007595

PMID:16710300 - Sws1 is a conserved regulator of homologous recombination in eukaryotic cells.

Martín V et al. EMBO J 2006 Jun 07;25(11):2564-74

PMID:15509785 - Biochemical interactions between proteins and mat1 cis-acting sequences required for imprinting in fission yeast.

Lee BS et al. Mol Cell Biol 2004 Nov;24(22):9813-22

PMID:32372157 - Characterisation of unessential genes required for survival under conditions of DNA stress.

Ahmed Ezzat H et al. J Genet Eng Biotechnol 2020 May 06;18(1):14

PMID:23071723 - DNA polymerase α (swi7) and the flap endonuclease Fen1 (rad2) act together in the S-phase alkylation damage response in S. pombe.

Koulintchenko M et al. PLoS One 2012;7(10):e47091

PMID:34608864 - DDK/Hsk1 phosphorylates and targets fission yeast histone deacetylase Hst4 for degradation to stabilize stalled DNA replication forks.

Aricthota S et al. Elife 2021 Oct 05;10

PMID:21504829 - Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Stewart EV et al. Mol Cell 2011 Apr 22;42(2):160-71

PMID:23703609 - TORC2 is required to maintain genome stability during S phase in fission yeast.

Schonbrun M et al. J Biol Chem 2013 Jul 05;288(27):19649-60

PMID:26173815 - Genome-wide screen of fission yeast mutants for sensitivity to 6-azauracil, an inhibitor of transcriptional elongation.

Zhou H et al. Yeast 2015 Oct;32(10):643-55

PMID:15767681 - Schizosaccharomyces pombe Swi1, Swi3, and Hsk1 are components of a novel S-phase response pathway to alkylation damage.

Sommariva E et al. Mol Cell Biol 2005 Apr;25(7):2770-84

PMID:11030618 - swi1 and swi3 perform imprinting, pausing, and termination of DNA replication in S. pombe.

Dalgaard JZ et al. Cell 2000 Sep 15;102(6):745-51

PMID:11387218 - A role for DNA polymerase alpha in epigenetic control of transcriptional silencing in fission yeast.

Nakayama Ji et al. EMBO J 2001 Jun 01;20(11):2857-66

PMID:20661445 - Rad3 decorates critical chromosomal domains with gammaH2A to protect genome integrity during S-Phase in fission yeast.

Rozenzhak S et al. PLoS Genet 2010 Jul 22;6(7):e1001032