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protein coding gene - lsm4 (SPBC30D10.06) - Lsm2-8 complex subunit Lsm4

Gene summary

Standard name
lsm4
Systematic ID
SPBC30D10.06
Product
Lsm2-8 complex subunit Lsm4
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O14352
ORFeome ID
04/04C09
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 3086053..3088916 reverse strand

Annotation

GO biological process

GO:0045292 - mRNA cis splicing, via spliceosome

References:

GO:0000956 - nuclear-transcribed mRNA catabolic process

References:

GO:0033962 - P-body assembly

References:

GO:0000387 - spliceosomal snRNP assembly

References:

GO:1905323 - telomerase holoenzyme complex assembly

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:1990726 - Lsm1-7-Pat1 complex

References:

GO:0120115 - Lsm2-8 complex

References:

GO:0005730 - nucleolus

References:

GO:0005634 - nucleus

References:

GO:0000932 - P-body

References:

GO:0005686 - U2 snRNP

References:

GO:0046540 - U4/U6 x U5 tri-snRNP complex

References:

GO:0005682 - U5 snRNP

References:

GO:0005688 - U6 snRNP

References:

GO molecular function

GO:0005515 - protein binding

References:

GO:0140691 - RNA folding chaperone

References:

GO:0030620 - U2 snRNA binding

References:

GO:0017070 - U6 snRNA binding

References:

Modification

MOD:01148 - ubiquitinylated lysine

References:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000059 - abnormal mitotic cell cycle

References:

Genotypes:

FYPO:0000314 - inviable after spore germination with elongated germ tube

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF01423LSMSm_dom_euk/arcPFAM
cd01723LSm4Lsm4CDD
PS52002SMSmPROSITE_PROFILES
SM00651Sm3Sm_dom_euk/arcSMART
G3DSA:2.30.30.100:FF:000024FUNFAM
SSF50182Sm-like ribonucleoproteinsLSM_dom_sfSUPERFAMILY
G3DSA:2.30.30.100GENE3D
PTHR23338SMALL NUCLEAR RIBONUCLEOPROTEIN SMLSm4/Sm_D1/D3PANTHER
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder
mobidb-lite-Positive-Polyelectrolytedisorder_predictionMOBIDB-Positive-Polyelectrolyte

Orthologs

References / Literature

PMID:33378677 - Quality-Control Mechanism for Telomerase RNA Folding in the Cell.
Hu X et al. Cell Rep 2020 Dec 29;33(13):108568
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
GO_REF:0000002 - Comments
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:29422501 - LARP7 family proteins have conserved function in telomerase assembly.
Collopy LC et al. Nat Commun 2018 Feb 08;9(1):557
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:29422664 - Pof8 is a La-related protein and a constitutive component of telomerase in fission yeast.
Páez-Moscoso DJ et al. Nat Commun 2018 Feb 08;9(1):587
PMID:22615807 - Crystal structures of Lsm3, Lsm4 and Lsm5/6/7 from Schizosaccharomyces pombe.
Wu D et al. PLoS One 2012;7(5):e36768
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.
Egan ED et al. RNA 2014 Jun;20(6):867-81
PMID:32518066 - Molecular basis for the distinct cellular functions of the Lsm1-7 and Lsm2-8 complexes.
Montemayor EJ et al. RNA 2020 Oct;26(10):1400-1413
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:22446625 - Telomerase RNA biogenesis involves sequential binding by Sm and Lsm complexes.
Tang W et al. Nature 2012 Mar 25;484(7393):260-4
PMID:22001694 - Structure of the LSm657 complex: an assembly intermediate of the LSm1-7 and LSm2-8 rings.
Mund M et al. J Mol Biol 2011 Nov 25;414(2):165-76
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:26292707 - Structure of a yeast spliceosome at 3.6-angstrom resolution.
Yan C et al. Science 2015 Sep 11;349(6253):1182-91
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
GO_REF:0000033 - Annotation inferences using phylogenetic trees