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protein coding gene - bpl1 (SPBC30D10.07c) - biotin-protein ligase Bpl1

Gene summary

Standard name
bpl1
Systematic ID
SPBC30D10.07c
Product
biotin-protein ligase Bpl1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O14353
ORFeome ID
46/46A11
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 3085966..3088899 forward strand

Annotation

PBO:0004349 - 6.3.4.15

Disease association

MONDO:0009666 - holocarboxylase synthetase deficiency

References:

MONDO:0005066 - metabolic disease

References:

MONDO:0015454 - multiple carboxylase deficiency

References:

GO biological process

GO:0051604 - protein maturation

References:

GO cellular component

GO:0005829 - cytosol

References:

GO molecular function

GO:0004077 - biotin--[biotin carboxyl-carrier protein] ligase activity

References:

Modification

MOD:01148 - ubiquitinylated lysine

References:

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PomGeneEx:0000012 - RNA level decreased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002021 - dispersed actin cortical patch localization during vegetative growth

References:

Genotypes:

FYPO:0002148 - inviable after spore germination, multiple cell divisions, abnormal morphology

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF02237BPL_CBPL_CPfam
PF03099BPL_LplA_LipBBPL_LPL_catalyticPfam
PF09825BPL_NBiotin-prot_ligase_NPfam
cd03144GATase1_ScBLP_likeCDD
cd16442BPLBiotin_CoA_COase_ligaseCDD
PS51733BPL_LPL_CATALYTICBPL_LPL_catalyticPROSITE profiles
G3DSA:3.30.930.10aa-tRNA-synth_II/BPL/LPLCATH-Gene3D
G3DSA:3.40.50.880Class_I_gatase-likeCATH-Gene3D
SSF52317Class_I_gatase-likeSUPERFAMILY
SSF55681aa-tRNA-synth_II/BPL/LPLSUPERFAMILY
PTHR12835Biotin_CoA_COase_ligasePANTHER
TIGR00121birA_ligaseBiotin_CoA_COase_ligaseNCBIFAM

Orthologs

References / Literature

PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
GO_REF:0000051 - S. pombe keyword mapping
PB_REF:0000003 - Disease Association Curation
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7