protein coding gene - bpl1 (SPBC30D10.07c) - biotin-protein ligase Bpl1

Gene summary

Standard name: bpl1
Systematic ID: SPBC30D10.07c
Product: biotin-protein ligase Bpl1
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: O14353
ORFeome ID: 46/46A11
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome II: 3085966..3088899 forward strand

Annotation

PBO:0004349 - 6.3.4.15

Disease association

MONDO:0009666 - holocarboxylase synthetase deficiency

References:

PB_REF:0000006

MONDO:0005066 - metabolic disease

References:

PB_REF:0000003

MONDO:0015454 - multiple carboxylase deficiency

References:

PB_REF:0000003

GO biological process

GO:0051604 - protein maturation

References:

GO_REF:0000051

GO cellular component

GO:0005829 - cytosol

References:

GO_REF:0000111

GO molecular function

GO:0004077 - biotin--[biotin carboxyl-carrier protein] ligase activity

References:

GO_REF:0000033

Modification

MOD:01148 - ubiquitinylated lysine

References:

PMID:37970674

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PMID:39367033

PomGeneEx:0000012 - RNA level decreased

References:

PMID:33313903

PomGeneEx:0000011 - RNA level increased

References:

PMID:12161753

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0002021 - dispersed actin cortical patch localization during vegetative growth

References:

PMID:23697806

Genotypes:

bpl1delta

FYPO:0002148 - inviable after spore germination, multiple cell divisions, abnormal morphology

References:

PMID:23697806

Genotypes:

bpl1delta

FYPO:0002061 - inviable vegetative cell population

References:

PMID:20473289

Genotypes:

bpl1delta

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF03099	BPL_LplA_LipB	BPL_LPL_catalytic	PFAM
PF09825	BPL_N	Biotin-prot_ligase_N	PFAM
PF02237	BPL_C	BPL_C	PFAM
cd16442	BPL	Biotin_CoA_COase_ligase	CDD
cd03144	GATase1_ScBLP_like		CDD
PS51733	BPL_LPL_CATALYTIC	BPL_LPL_catalytic	PROSITE_PROFILES
SSF55681	Class II aaRS and biotin synthetases	aa-tRNA-synth_II/BPL/LPL	SUPERFAMILY
SSF52317	Class I glutamine amidotransferase-like	Class_I_gatase-like	SUPERFAMILY
G3DSA:3.40.50.880		Class_I_gatase-like	GENE3D
G3DSA:3.30.930.10	Bira Bifunctional Protein; Domain 2	aa-tRNA-synth_II/BPL/LPL	GENE3D
PTHR12835	BIOTIN PROTEIN LIGASE		PANTHER
TIGR00121	birA_ligase	Biotin_CoA_COase_ligase	NCBIFAM

Orthologs

HLCS (HGNC:4976) Homo sapiens
bpl1 (SJAG_03069) Schizosaccharomyces japonicus
BPL1 (YDL141W) Saccharomyces cerevisiae

References / Literature

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.: Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
GO_REF:0000051 - S. pombe keyword mapping
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.: Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.: Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.: Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.: Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PB_REF:0000003 - Disease Association Curation
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36