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protein coding gene - hva22 (SPBC30D10.09c) - ER membrane organization protein, HVA22/TB2/DP1 family protein

Gene summary

Standard name
hva22
Systematic ID
SPBC30D10.09c
Product
ER membrane organization protein, HVA22/TB2/DP1 family protein
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
rop1, yep1
UniProt ID
O14355
ORFeome ID
10/10A04
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 3083400..3084348 forward strand

Annotation

Complementation

PBO:0119270 - functionally complemented by human REEP1

References:

PBO:0119271 - functionally complemented by human REEP2

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PBO:0119272 - functionally complemented by human REEP3

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PBO:0119273 - functionally complemented by human REEP4

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PBO:0119274 - functionally complemented by S. cerevisiae YOR152C

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Disease association

MONDO:0012453 - hereditary spastic paraplegia 31

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MONDO:0014282 - hereditary spastic paraplegia 72

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MONDO:0013884 - neuronopathy, distal hereditary motor, type 5B

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MONDO:0957958 - spastic paraplegia 72b, autosomal recessive

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MONDO:0859279 - spinal muscular atrophy, distal, autosomal recessive, 6

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GO biological process

GO:0000045 - autophagosome assembly

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GO:0006914 - autophagy

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GO:0090158 - endoplasmic reticulum membrane organization

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GO:1990809 - endoplasmic reticulum tubular network membrane organization

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GO:0061736 - engulfment of target by autophagosome

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GO:0016236 - macroautophagy

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GO:0044804 - nucleophagy

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GO:0061709 - reticulophagy

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GO cellular component

GO:0005783 - endoplasmic reticulum

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GO:0061908 - phagophore

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GO:0012506 - vesicle membrane

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GO molecular function

GO:0180020 - membrane bending activity

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Modification

MOD:00046 - O-phospho-L-serine

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Multi-locus phenotype

FYPO:0000164 - abnormal cell separation after cytokinesis

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Genotypes:

FYPO:0006433 - abnormal tubular endoplasmic reticulum morphology

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Genotypes:

FYPO:0000381 - decreased macroautophagy

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Genotypes:

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0008388 - abnormal autophagosomal enclosure during nucleophagy

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Genotypes:

FYPO:0000164 - abnormal cell separation after cytokinesis

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Genotypes:

FYPO:0001013 - abnormal membrane organization

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Genotypes:

FYPO:0008083 - abnormal reticulophagy

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Genotypes:

FYPO:0007445 - abnormal reticulophagy during vegetative growth

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Genotypes:

FYPO:0008385 - abolished nucleophagy during cellular response to Endoplasmic Reticulum stress

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Genotypes:

FYPO:0008086 - abolished nucleophagy during nitrogen starvation

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Genotypes:

FYPO:0000705 - abolished protein-protein interaction

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Genotypes:

FYPO:0007447 - abolished reticulophagy during cellular response to endoplasmic reticulum stress

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Genotypes:

FYPO:0008084 - abolished reticulophagy during nitrogen starvation

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Genotypes:

FYPO:0000684 - decreased cell population growth on glycerol carbon source

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Genotypes:

FYPO:0009091 - decreased cell population growth on lysine and proline nitrogen source

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Genotypes:

FYPO:0009073 - decreased cell population growth on lysine nitrogen source

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Genotypes:

FYPO:0000250 - decreased cell population growth on proline nitrogen source

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Genotypes:

FYPO:0007562 - decreased cell population growth on serine nitrogen source

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Genotypes:

FYPO:0000381 - decreased macroautophagy

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Genotypes:

FYPO:0000470 - decreased mating type switching

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Genotypes:

FYPO:0007596 - decreased mitophagy during nitrogen starvation

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Genotypes:

FYPO:0000526 - decreased peroxisome degradation

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Genotypes:

FYPO:0006376 - decreased protein processing during nitrogen starvation

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Genotypes:

FYPO:0007446 - decreased reticulophagy during cellular response to endoplasmic reticulum stress

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Genotypes:

FYPO:0008197 - decreased reticulophagy during vegetative growth

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Genotypes:

FYPO:0004344 - increased viability upon nitrogen starvation

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Genotypes:

FYPO:0000355 - normal endoplasmic reticulum morphology

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Genotypes:

FYPO:0001030 - normal growth on dithiothreitol

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Genotypes:

FYPO:0007444 - normal macroautophagy during cellular response to endoplasmic reticulum stress

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Genotypes:

FYPO:0006294 - normal macroautophagy during nitrogen starvation

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Genotypes:

FYPO:0008387 - normal protein localization to autophagic structure

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Genotypes:

FYPO:0001357 - normal vegetative cell population growth

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Genotypes:

FYPO:0000763 - resistance to cadmium

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Genotypes:

FYPO:0002693 - resistance to diamide

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

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Genotypes:

FYPO:0006930 - sensitive to butylated hydroxyanisole

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Genotypes:

FYPO:0009069 - sensitive to ciclopirox olamine

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Genotypes:

FYPO:0000843 - sensitive to dithiothreitol

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Genotypes:

FYPO:0007931 - sensitive to egtazic acid

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Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

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Genotypes:

FYPO:0006836 - sensitive to magnesium chloride

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Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

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Genotypes:

FYPO:0000091 - sensitive to thiabendazole

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Warnings

PBO:0000070 - gene structure updated

Protein features

IDNameInterPro nameDB name
PF03134TB2_DP1_HVA22TB2_DP1_HVA22PFAM
PTHR12300HVA22-LIKE PROTEINSTB2_DP1_HVA22PANTHER

Orthologs

References / Literature

PMID:29852001 - New insights into donor directionality of mating-type switching in Schizosaccharomyces pombe.
Maki T et al. PLoS Genet 2018 May;14(5):e1007424
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:33109728 - High-Throughput Identification of Nuclear Envelope Protein Interactions in Schizosaccharomyces pombe Using an Arrayed Membrane Yeast-Two Hybrid Library.
Varberg JM et al. G3 (Bethesda) 2020 Dec 03;10(12):4649-4663
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:37939137 - The ortholog of human REEP1-4 is required for autophagosomal enclosure of ER-phagy/nucleophagy cargos in fission yeast.
Zou CX et al. PLoS Biol 2023 Nov;21(11):e3002372
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:23173672 - Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.
Pan X et al. BMC Genomics 2012 Nov 23;13:662
PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
Paulo JA et al. J Proteomics 2020 Jan 06;210:103531
PMID:37191320 - Hva22, a REEP family protein in fission yeast, promotes reticulophagy in collaboration with a receptor protein.
Fukuda T et al. Autophagy 2023 Oct;19(10):2657-2667
PMID:37553386 - A conserved membrane curvature-generating protein is crucial for autophagosome formation in fission yeast.
Wang N et al. Nat Commun 2023 Aug 08;14(1):4765
PMID:30647105 - Comparative Genomic Screen in Two Yeasts Reveals Conserved Pathways in the Response Network to Phenol Stress.
Alhoch B et al. G3 (Bethesda) 2019 Mar 07;9(3):639-650
PMID:25452419 - Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.
Sideri T et al. G3 (Bethesda) 2014 Dec 01;5(1):145-55
PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.
Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895
PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.
Rallis C et al. Sci Rep 2017 Mar 10;7:44257