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protein coding gene - tor1 (SPBC30D10.10c) - TORC2 serine/threonine protein kinase Tor1

Gene summary

Standard name
tor1
Systematic ID
SPBC30D10.10c
Product
TORC2 serine/threonine protein kinase Tor1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O14356
ORFeome ID
48/48H11
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 3075748..3083248 forward strand

Annotation

PBO:0002663 - 2.7.1.137

Disease association

MONDO:0011818 - isolated focal cortical dysplasia type II

References:

MONDO:0014716 - macrocephaly-intellectual disability-neurodevelopmental disorder-small thorax syndrome

References:

MONDO:0100283 - overgrowth syndrome and/or cerebral malformations due to abnormalities in MTOR pathway genes

References:

GO biological process

GO:0010972 - negative regulation of G2/M transition of mitotic cell cycle

References:

GO:0061188 - negative regulation of rDNA heterochromatin formation

References:

GO:0000122 - negative regulation of transcription by RNA polymerase II

References:

GO:0031139 - positive regulation of conjugation with cellular fusion

References:

GO:0010971 - positive regulation of G2/M transition of mitotic cell cycle

References:

GO:0045944 - positive regulation of transcription by RNA polymerase II

References:

GO:0043610 - regulation of carbohydrate utilization

References:

GO:0038203 - TORC2 signaling

References:

GO cellular component

GO:0005938 - cell cortex

References:

GO:0000785 - chromatin

References:

GO:0005737 - cytoplasm

References:

GO:0005829 - cytosol

References:

GO:0030874 - nucleolar chromatin

References:

GO:0031932 - TORC2 complex

References:

GO molecular function

GO:0005515 - protein binding

References:

GO:0004672 - protein kinase activity

References:

GO:0004674 - protein serine/threonine kinase activity

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

MOD:00696 - phosphorylated residue

References:

Multi-locus phenotype

FYPO:0000400 - abnormal cell cycle arrest at mitotic G2/M phase transition

References:

Genotypes:

FYPO:0000444 - abnormal mitotic cell cycle arrest with replicated DNA

References:

Genotypes:

FYPO:0001430 - abnormal mitotic cell cycle arrest with unreplicated DNA

References:

Genotypes:

FYPO:0004481 - abolished cell population growth at high temperature

References:

Genotypes:

FYPO:0000229 - cut

References:

Genotypes:

FYPO:0000082 - decreased cell population growth at high temperature

References:

Genotypes:

FYPO:0008378 - decreased histone H2A phosphorylation during cellular response to camptothecin

References:

Genotypes:

FYPO:0008379 - decreased histone H2A phosphorylation during nitrogen starvation

References:

Genotypes:

FYPO:0001140 - decreased leucine import

References:

Genotypes:

FYPO:0000708 - decreased mating efficiency

References:

Genotypes:

FYPO:0006470 - decreased mature rRNA level

References:

Genotypes:

FYPO:0005034 - decreased protein phosphorylation during nitrogen starvation

References:

Genotypes:

FYPO:0001838 - decreased protein phosphorylation during vegetative growth

References:

Genotypes:

FYPO:0002975 - decreased RNA level during cellular response to hydroxyurea

References:

Genotypes:

FYPO:0001117 - decreased RNA level during vegetative growth

References:

Genotypes:

FYPO:0004085 - decreased vegetative cell growth

References:

Genotypes:

FYPO:0002019 - elongated telomeres during vegetative growth

References:

Genotypes:

FYPO:0001122 - elongated vegetative cell

References:

Genotypes:

FYPO:0000761 - increased conjugation frequency

References:

Genotypes:

FYPO:0006074 - increased histone H3-K9 dimethylation at rDNA during vegetative growth

References:

Genotypes:

FYPO:0007526 - increased protein phosphorylation during cellular response to salt stress

References:

Genotypes:

FYPO:0001309 - increased viability in stationary phase

References:

Genotypes:

FYPO:0002262 - inviable after spore germination, multiple cell divisions, elongated cell

References:

Genotypes:

FYPO:0001490 - inviable elongated vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0000674 - normal cell population growth at high temperature

References:

Genotypes:

FYPO:0004765 - normal cell population growth during glucose starvation

References:

Genotypes:

FYPO:0003086 - normal chromatin binding

References:

Genotypes:

FYPO:0002336 - normal chromatin silencing at silent mating-type cassette

References:

Genotypes:

FYPO:0003555 - normal chromatin silencing at subtelomere

References:

Genotypes:

FYPO:0001021 - normal growth during cellular response to osmotic stress

References:

Genotypes:

FYPO:0001688 - normal growth on brefeldin A

References:

Genotypes:

FYPO:0001522 - normal growth on caffeine

References:

Genotypes:

FYPO:0000960 - normal growth on ethanol

References:

Genotypes:

FYPO:0001164 - normal growth on glucose carbon source

References:

Genotypes:

FYPO:0003809 - normal growth on latrunculin A

References:

Genotypes:

FYPO:0008380 - normal histone H2A phosphorylation during cellular response to camptothecin

References:

Genotypes:

FYPO:0006395 - normal histone H3-K9 acetylation at subtelomeric heterochromatin during vegetative growth

References:

Genotypes:

FYPO:0003223 - normal histone H3-K9 acetylation during vegetative growth

References:

Genotypes:

FYPO:0008364 - normal histone H3-K9 trimethylation at silent mating-type cassette during vegetative growth

References:

Genotypes:

FYPO:0005572 - normal protein localization to cell periphery

References:

Genotypes:

FYPO:0003576 - normal protein localization to subtelomeric heterochromatin

References:

Genotypes:

FYPO:0004422 - normal protein phosphorylation

References:

Genotypes:

FYPO:0005602 - normal subtelomeric heterochromatin RNA level

References:

Genotypes:

FYPO:0006742 - normal transcription from MCB promoter

References:

Genotypes:

FYPO:0001032 - resistance to camptothecin

References:

Genotypes:

FYPO:0002578 - resistance to hydroxyurea

References:

Genotypes:

FYPO:0001501 - sensitive to brefeldin A

References:

Genotypes:

FYPO:0000098 - sensitive to calcium

References:

Genotypes:

FYPO:0000085 - sensitive to camptothecin

References:

Genotypes:

FYPO:0000099 - sensitive to canavanine

References:

Genotypes:

FYPO:0000081 - sensitive to high osmolarity

References:

Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

References:

Genotypes:

FYPO:0001525 - sensitive to L-thialysine

References:

Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

References:

Genotypes:

FYPO:0000111 - sensitive to rapamycin

References:

Genotypes:

FYPO:0000271 - sensitive to salt stress

References:

Genotypes:

FYPO:0000091 - sensitive to thiabendazole

References:

Genotypes:

FYPO:0002239 - shortened telomeres during vegetative growth

References:

Genotypes:

FYPO:0002788 - small vacuoles during vegetative growth

References:

Genotypes:

FYPO:0000280 - sterile

References:

Genotypes:

FYPO:0001492 - viable elongated vegetative cell

References:

Genotypes:

FYPO:0003481 - viable elongated vegetative cell, elongated upon mitotic entry

References:

Genotypes:

FYPO:0006822 - viable small vegetative cell with normal cell growth rate

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0004840 - abnormal high-affinity glucose import

References:

Genotypes:

FYPO:0000710 - abnormal mitotic cell cycle arrest in response to nitrogen starvation

References:

Genotypes:

FYPO:0005189 - abnormal re-entry into mitotic cell cycle after arrest in response to hydroxyurea

References:

Genotypes:

FYPO:0003345 - abolished cell cycle arrest in mitotic G1 phase in response to nitrogen starvation

References:

Genotypes:

FYPO:0004481 - abolished cell population growth at high temperature

References:

Genotypes:

FYPO:0003255 - abolished proline import

References:

Genotypes:

FYPO:0001384 - abolished protein kinase activity

References:

Genotypes:

FYPO:0005571 - abolished protein localization to cell periphery during vegetative growth

References:

Genotypes:

FYPO:0004839 - abolished protein localization to plasma membrane, with protein mislocalized to cytoplasm, during glucose starvation

References:

Genotypes:

FYPO:0002678 - abolished protein phosphorylation

References:

Genotypes:

FYPO:0002033 - abolished protein phosphorylation during vegetative growth

References:

Genotypes:

FYPO:0000705 - abolished protein-protein interaction

References:

Genotypes:

FYPO:0003425 - abolished protein-protein interaction during cellular response to rapamycin

References:

Genotypes:

FYPO:0002133 - abolished protein-RNA interaction

References:

Genotypes:

FYPO:0000583 - abolished sporulation

References:

Genotypes:

FYPO:0005430 - aggregated actin cortical patches during vegetative growth

References:

Genotypes:

FYPO:0000711 - decreased cell cycle arrest in mitotic G1 phase in response to nitrogen starvation

References:

Genotypes:

FYPO:0001187 - decreased cell density in stationary phase

References:

Genotypes:

FYPO:0000082 - decreased cell population growth at high temperature

References:

Genotypes:

FYPO:0000080 - decreased cell population growth at low temperature

References:

Genotypes:

FYPO:0003743 - decreased cell population growth during glucose starvation

References:

Genotypes:

FYPO:0009078 - decreased cell population growth on ethanol carbon source

References:

Genotypes:

FYPO:0000251 - decreased cell population growth on galactose carbon source

References:

Genotypes:

FYPO:0001407 - decreased cell population growth on glucose carbon source

References:

Genotypes:

FYPO:0009053 - decreased cell population growth on glutamate nitrogen source

References:

Genotypes:

FYPO:0009100 - decreased cell population growth on glycerol and galactose carbon source

References:

Genotypes:

FYPO:0000684 - decreased cell population growth on glycerol carbon source

References:

Genotypes:

FYPO:0009091 - decreased cell population growth on lysine and proline nitrogen source

References:

Genotypes:

FYPO:0002924 - decreased cell population growth on maltose carbon source

References:

Genotypes:

FYPO:0009099 - decreased cell population growth on mannitol carbon source

References:

Genotypes:

FYPO:0009097 - decreased cell population growth on xylose carbon source

References:

Genotypes:

FYPO:0002827 - decreased chromatin silencing at silent mating-type cassette

References:

Genotypes:

FYPO:0004604 - decreased chromatin silencing at subtelomere

References:

Genotypes:

FYPO:0002340 - decreased DNA recombination during vegetative growth

References:

Genotypes:

FYPO:0000185 - decreased gene conversion during vegetative growth

References:

Genotypes:

FYPO:0006549 - decreased gene expression

References:

Genotypes:

FYPO:0008378 - decreased histone H2A phosphorylation during cellular response to camptothecin

References:

Genotypes:

FYPO:0008438 - decreased histone H2A phosphorylation during cellular response to methyl methanesulfonate

References:

Genotypes:

FYPO:0008379 - decreased histone H2A phosphorylation during nitrogen starvation

References:

Genotypes:

FYPO:0004137 - decreased histone H3-K9 dimethylation at subtelomeric heterochromatin during vegetative growth

References:

Genotypes:

FYPO:0005845 - decreased histone H3-K9 trimethylation at silent mating-type cassette during vegetative growth

References:

Genotypes:

FYPO:0006753 - decreased histone H4-K20 dimethylation at subtelomeric heterochromatin during vegetative growth

References:

Genotypes:

FYPO:0001140 - decreased leucine import

References:

Genotypes:

FYPO:0005187 - decreased level of transport gene mRNA during vegetative growth

References:

Genotypes:

FYPO:0000708 - decreased mating efficiency

References:

Genotypes:

FYPO:0000470 - decreased mating type switching

References:

Genotypes:

FYPO:0001382 - decreased protein kinase activity

References:

Genotypes:

FYPO:0000835 - decreased protein level

References:

Genotypes:

FYPO:0004194 - decreased protein level during cellular response to hydroxyurea

References:

Genotypes:

FYPO:0001324 - decreased protein level during vegetative growth

References:

Genotypes:

FYPO:0002976 - decreased protein localization to chromatin at MCB promoters during cellular response to hydroxyurea

References:

Genotypes:

FYPO:0005314 - decreased protein localization to chromatin at MCB promoters during vegetative growth

References:

Genotypes:

FYPO:0002391 - decreased protein localization to chromatin at rDNA

References:

Genotypes:

FYPO:0002387 - decreased protein localization to subtelomeric heterochromatin during vegetative growth

References:

Genotypes:

FYPO:0002679 - decreased protein phosphorylation

References:

Genotypes:

FYPO:0005034 - decreased protein phosphorylation during nitrogen starvation

References:

Genotypes:

FYPO:0001838 - decreased protein phosphorylation during vegetative growth

References:

Genotypes:

FYPO:0006494 - decreased rDNA copy number during vegetative growth

References:

Genotypes:

FYPO:0002975 - decreased RNA level during cellular response to hydroxyurea

References:

Genotypes:

FYPO:0001152 - decreased RNA level during nitrogen starvation

References:

Genotypes:

FYPO:0001117 - decreased RNA level during vegetative growth

References:

Genotypes:

FYPO:0004009 - decreased rRNA transcription

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0008128 - decreased vegetative cell population growth on low glucose

References:

Genotypes:

FYPO:0009007 - decreased vegetative cell population viability

References:

Genotypes:

FYPO:0005188 - delayed onset of mitotic cell cycle arrest during cellular response to hydroxyurea

References:

Genotypes:

FYPO:0002830 - delayed onset of protein phosphorylation during vegetative growth

References:

Genotypes:

FYPO:0004427 - delayed onset of ribosomal S6 protein dephosphorylation during cellular response to nitrogen starvation

References:

Genotypes:

FYPO:0000017 - elongated cell

References:

Genotypes:

FYPO:0005077 - elongated cell during glucose starvation

References:

Genotypes:

FYPO:0000998 - elongated cell during nitrogen starvation

References:

Genotypes:

FYPO:0003160 - elongated cell during stationary phase

References:

Genotypes:

FYPO:0002019 - elongated telomeres during vegetative growth

References:

Genotypes:

FYPO:0001122 - elongated vegetative cell

References:

Genotypes:

FYPO:0005261 - increased cell population growth on galactose carbon source

References:

Genotypes:

FYPO:0009011 - increased cell population viability on galactose carbon source

References:

Genotypes:

FYPO:0009016 - increased cell population viability on xylose carbon source

References:

Genotypes:

FYPO:0002341 - increased duration of mitotic DNA damage checkpoint

References:

Genotypes:

FYPO:0006751 - increased histone H3-K4 trimethylation at subtelomeric heterochromatin during vegetative growth

References:

Genotypes:

FYPO:0004575 - increased histone H3-K9 acetylation at subtelomere during vegetative growth

References:

Genotypes:

FYPO:0006074 - increased histone H3-K9 dimethylation at rDNA during vegetative growth

References:

Genotypes:

FYPO:0003746 - increased histone H3-K9 methylation at heterochromatin island during vegetative growth

References:

Genotypes:

FYPO:0006077 - increased histone H3-K9 methylation at rDNA during vegetative growth

References:

Genotypes:

FYPO:0005316 - increased histone H4-K12 acetylation at subtelomere during vegetative growth

References:

Genotypes:

FYPO:0006752 - increased histone H4-K16 acetylation at subtelomeric heterochromatin during vegetative growth

References:

Genotypes:

FYPO:0000972 - increased number of Rad52 foci during vegetative growth

References:

Genotypes:

FYPO:0000847 - increased protein degradation during vegetative growth

References:

Genotypes:

FYPO:0002700 - increased protein kinase activity

References:

Genotypes:

FYPO:0001327 - increased protein level during vegetative growth

References:

Genotypes:

FYPO:0002852 - increased protein localization to cell tip during vegetative growth

References:

Genotypes:

FYPO:0006740 - increased protein localization to chromatin at MCB promoters during vegetative growth

References:

Genotypes:

FYPO:0004032 - increased protein localization to chromatin at rDNA

References:

Genotypes:

FYPO:0006552 - increased protein localization to cytoplasm

References:

Genotypes:

FYPO:0003010 - increased protein localization to subtelomeric heterochromatin during vegetative growth

References:

Genotypes:

FYPO:0002680 - increased protein phosphorylation

References:

Genotypes:

FYPO:0007526 - increased protein phosphorylation during cellular response to salt stress

References:

Genotypes:

FYPO:0002681 - increased protein phosphorylation during nitrogen starvation

References:

Genotypes:

FYPO:0001038 - increased protein phosphorylation during vegetative growth

References:

Genotypes:

FYPO:0002082 - increased protein ubiquitination during vegetative growth

References:

Genotypes:

FYPO:0000650 - increased septation index

References:

Genotypes:

FYPO:0005917 - increased subtelomeric heterochromatin RNA level

References:

Genotypes:

FYPO:0009008 - increased vegetative cell population viability

References:

Genotypes:

FYPO:0001309 - increased viability in stationary phase

References:

Genotypes:

FYPO:0004163 - increased viability upon glucose starvation

References:

Genotypes:

FYPO:0004343 - increased wtf-derived RNA level

References:

Genotypes:

FYPO:0001490 - inviable elongated vegetative cell

References:

Genotypes:

FYPO:0004104 - inviable spherical vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0000245 - loss of viability in stationary phase

References:

Genotypes:

FYPO:0005231 - loss of viability in stationary phase upon glucose starvation

References:

Genotypes:

FYPO:0000339 - mislocalized septum during vegetative growth

References:

Genotypes:

FYPO:0000012 - mitotic G2/M phase transition delay

References:

Genotypes:

FYPO:0001019 - monopolar actin cortical patch localization during vegetative growth

References:

Genotypes:

FYPO:0004652 - normal actomyosin contractile ring morphology

References:

Genotypes:

FYPO:0000674 - normal cell population growth at high temperature

References:

Genotypes:

FYPO:0001925 - normal cellular response to gamma radiation

References:

Genotypes:

FYPO:0002567 - normal centromeric outer repeat transcript level

References:

Genotypes:

FYPO:0002360 - normal chromatin silencing at centromere

References:

Genotypes:

FYPO:0006142 - normal G0 to G1 transition

References:

Genotypes:

FYPO:0001037 - normal growth during cellular response to salt stress

References:

Genotypes:

FYPO:0001020 - normal growth on calcium

References:

Genotypes:

FYPO:0001164 - normal growth on glucose carbon source

References:

Genotypes:

FYPO:0002672 - normal growth on rapamycin

References:

Genotypes:

FYPO:0000961 - normal growth on sorbitol

References:

Genotypes:

FYPO:0000862 - normal histone H3-K9 dimethylation at centromere during vegetative growth

References:

Genotypes:

FYPO:0002259 - normal leucine import

References:

Genotypes:

FYPO:0002801 - normal protein degradation during nitrogen starvation

References:

Genotypes:

FYPO:0005168 - normal protein level during cellular response to salt stress

References:

Genotypes:

FYPO:0000833 - normal protein level during vegetative growth

References:

Genotypes:

FYPO:0001509 - normal protein localization to chromatin during vegetative growth

References:

Genotypes:

FYPO:0002625 - normal protein localization to chromatin rDNA

References:

Genotypes:

FYPO:0002389 - normal protein localization to heterochromatin at centromere outer repeat

References:

Genotypes:

FYPO:0007705 - normal protein localization to lateral cell cortex during glucose starvation

References:

Genotypes:

FYPO:0006554 - normal protein localization to nucleus during nitrogen starvation

References:

Genotypes:

FYPO:0002899 - normal protein phosphorylation during cellular response to DNA damage

References:

Genotypes:

FYPO:0002099 - normal protein phosphorylation during cellular response to hydroxyurea

References:

Genotypes:

FYPO:0001266 - normal protein phosphorylation during cellular response to salt stress

References:

Genotypes:

FYPO:0005035 - normal protein phosphorylation during nitrogen starvation

References:

Genotypes:

FYPO:0001668 - normal protein processing during vegetative growth

References:

Genotypes:

FYPO:0004423 - normal protein threonine phosphorylation

References:

Genotypes:

FYPO:0000703 - normal protein-protein interaction

References:

Genotypes:

FYPO:0002357 - normal protein-RNA interaction

References:

Genotypes:

FYPO:0003828 - normal ribosomal S6 protein phosphorylation during vegetative growth

References:

Genotypes:

FYPO:0001246 - normal RNA level during cellular response to hydrogen peroxide

References:

Genotypes:

FYPO:0001486 - normal RNA level during cellular response to salt stress

References:

Genotypes:

FYPO:0001096 - normal RNA level during nitrogen starvation

References:

Genotypes:

FYPO:0001317 - normal RNA level during vegetative growth

References:

Genotypes:

FYPO:0005602 - normal subtelomeric heterochromatin RNA level

References:

Genotypes:

FYPO:0001770 - normal tRNA methyltransferase activity

References:

Genotypes:

FYPO:0002085 - normal vegetative cell growth

References:

Genotypes:

FYPO:0001420 - normal vegetative cell population growth rate

References:

Genotypes:

FYPO:0001310 - normal viability in stationary phase

References:

Genotypes:

FYPO:0000441 - resistance to antimycin A

References:

Genotypes:

FYPO:0000073 - resistance to caffeine

References:

Genotypes:

FYPO:0001029 - resistance to canavanine

References:

Genotypes:

FYPO:0009047 - resistance to dimethyl sulfoxide

References:

Genotypes:

FYPO:0009038 - resistance to egtazic acid

References:

Genotypes:

FYPO:0001453 - resistance to ethanol

References:

Genotypes:

FYPO:0009034 - resistance to ethylenediaminetetraacetic acid

References:

Genotypes:

FYPO:0009035 - resistance to formamide

References:

Genotypes:

FYPO:0001103 - resistance to hydrogen peroxide

References:

Genotypes:

FYPO:0009050 - resistance to hydroxyurea and methyl methanesulfonate

References:

Genotypes:

FYPO:0004513 - resistance to latrunculin A

References:

Genotypes:

FYPO:0001583 - resistance to lithium

References:

Genotypes:

FYPO:0000725 - resistance to methyl methanesulfonate

References:

Genotypes:

FYPO:0009046 - resistance to phloxine B and hydrogen peroxide

References:

Genotypes:

FYPO:0009039 - resistance to potassium chloride

References:

Genotypes:

FYPO:0000077 - resistance to rapamycin

References:

Genotypes:

FYPO:0000852 - resistance to salt stress

References:

Genotypes:

FYPO:0005968 - resistance to sodium chloride

References:

Genotypes:

FYPO:0009042 - resistance to sorbitol

References:

Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

References:

Genotypes:

FYPO:0005193 - resistance to torin1

References:

Genotypes:

FYPO:0001034 - resistance to tunicamycin

References:

Genotypes:

FYPO:0000830 - resistance to vanadate

References:

Genotypes:

FYPO:0003161 - RNA absent from cell during vegetative growth

References:

Genotypes:

FYPO:0007933 - sensitive to 2,2′-dipyridyl

References:

Genotypes:

FYPO:0001097 - sensitive to amitrole

References:

Genotypes:

FYPO:0000095 - sensitive to bleomycin

References:

Genotypes:

FYPO:0001701 - sensitive to bortezomib

References:

Genotypes:

FYPO:0001501 - sensitive to brefeldin A

References:

Genotypes:

FYPO:0000096 - sensitive to cadmium

References:

Genotypes:

FYPO:0000097 - sensitive to caffeine during vegetative growth

References:

Genotypes:

FYPO:0000098 - sensitive to calcium

References:

Genotypes:

FYPO:0000085 - sensitive to camptothecin

References:

Genotypes:

FYPO:0000099 - sensitive to canavanine

References:

Genotypes:

FYPO:0000104 - sensitive to cycloheximide

References:

Genotypes:

FYPO:0000799 - sensitive to diamide

References:

Genotypes:

FYPO:0007931 - sensitive to egtazic acid

References:

Genotypes:

FYPO:0000842 - sensitive to ethanol during vegetative growth

References:

Genotypes:

FYPO:0007928 - sensitive to ethylenediaminetetraacetic acid

References:

Genotypes:

FYPO:0000785 - sensitive to formamide

References:

Genotypes:

FYPO:0001408 - sensitive to heat shock

References:

Genotypes:

FYPO:0000081 - sensitive to high osmolarity

References:

Genotypes:

FYPO:0001987 - sensitive to high pH

References:

Genotypes:

FYPO:0000087 - sensitive to hydrogen peroxide

References:

Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

References:

Genotypes:

FYPO:0009071 - sensitive to itraconazole

References:

Genotypes:

FYPO:0001525 - sensitive to L-thialysine

References:

Genotypes:

FYPO:0001719 - sensitive to lithium

References:

Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0006836 - sensitive to magnesium chloride

References:

Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

References:

Genotypes:

FYPO:0001214 - sensitive to potassium chloride

References:

Genotypes:

FYPO:0009082 - sensitive to potassium chloride and methyl methanesulfonate

References:

Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000111 - sensitive to rapamycin

References:

Genotypes:

FYPO:0000271 - sensitive to salt stress

References:

Genotypes:

FYPO:0007925 - sensitive to sodium chloride and methyl methanesulfonate

References:

Genotypes:

FYPO:0000841 - sensitive to sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000797 - sensitive to tert-butyl hydroperoxide

References:

Genotypes:

FYPO:0000091 - sensitive to thiabendazole

References:

Genotypes:

FYPO:0002546 - sensitive to trichostatin A

References:

Genotypes:

FYPO:0001457 - sensitive to tunicamycin

References:

Genotypes:

FYPO:0000268 - sensitive to UV during vegetative growth

References:

Genotypes:

FYPO:0000115 - sensitive to valproic acid

References:

Genotypes:

FYPO:0003656 - sensitive to vanadate

References:

Genotypes:

FYPO:0001234 - slow vegetative cell population growth

References:

Genotypes:

FYPO:0002788 - small vacuoles during vegetative growth

References:

Genotypes:

FYPO:0000280 - sterile

References:

Genotypes:

FYPO:0001492 - viable elongated vegetative cell

References:

Genotypes:

FYPO:0003481 - viable elongated vegetative cell, elongated upon mitotic entry

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00454PI3_PI4_kinasePI3/4_kinase_cat_domPfam
PF02259FATPIK-rel_kinase_FATPfam
PF02260FATCFATC_domPfam
PF08771FRB_domFRB_domPfam
PF11865mTOR_dommTOR_domPfam
PF23593HEAT_ATRHEAT_ATRPfam
PF25574TPR_IMB1IMB1_TNPO1-like_TPRPfam
cd05169PIKKc_TORTOR_catCDD
PS00915PI3_4_KINASE_1PI3/4_kinase_CSPROSITE patterns
PS00916PI3_4_KINASE_2PI3/4_kinase_CSPROSITE patterns
PS50290PI3_4_KINASE_3PI3/4_kinase_cat_domPROSITE profiles
PS51189FATPIK_FATPROSITE profiles
PS51190FATCFATC_domPROSITE profiles
SM00146PI3KcPI3/4_kinase_cat_domSMART
SM01343FATCFATC_domSMART
SM01345Rapamycin_bindSMART
SM01346DUF3385mTOR_domSMART
G3DSA:1.10.1070.11:FF:000007CATH-FunFam
G3DSA:1.20.120.150:FF:000001CATH-FunFam
G3DSA:1.25.10.10:FF:000371CATH-FunFam
G3DSA:1.25.10.10:FF:000582CATH-FunFam
G3DSA:1.25.40.10:FF:003516CATH-FunFam
G3DSA:3.30.1010.10:FF:000004CATH-FunFam
G3DSA:1.10.1070.11PI3/4_kinase_cat_sfCATH-Gene3D
G3DSA:1.20.120.150FRB_sfCATH-Gene3D
G3DSA:1.25.10.10ARM-likeCATH-Gene3D
G3DSA:1.25.40.10TPR-like_helical_dom_sfCATH-Gene3D
G3DSA:3.30.1010.10CATH-Gene3D
SSF47212FRB_sfSUPERFAMILY
SSF48371ARM-type_foldSUPERFAMILY
SSF56112Kinase-like_dom_sfSUPERFAMILY
PTHR11139DDR_Repair_KinasePANTHER

Orthologs

References / Literature

PMID:34028542 - TORC2 inhibition of α-arrestin Aly3 mediates cell surface persistence of S. pombe Ght5 glucose transporter in low glucose.
Toyoda Y et al. J Cell Sci 2021 May 15;134(10)
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:17046992 - Fission yeast Tor2 promotes cell growth and represses cell differentiation.
Alvarez B et al. J Cell Sci 2006 Nov 01;119(Pt 21):4475-85
PMID:27887640 - Functional and regulatory profiling of energy metabolism in fission yeast.
Malecki M et al. Genome Biol 2016 Nov 25;17(1):240
PMID:31477575 - Modulation of TOR complex 2 signaling by the stress-activated MAPK pathway in fission yeast.
Morigasaki S et al. J Cell Sci 2019 Oct 10;132(19)
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:31748520 - Chaperone-mediated ordered assembly of the SAGA and NuA4 transcription co-activator complexes in yeast.
Elías-Villalobos A et al. Nat Commun 2019 Nov 20;10(1):5237
PMID:34686329 - The Hsp90 cochaperone TTT promotes cotranslational maturation of PIKKs prior to complex assembly.
Toullec D et al. Cell Rep 2021 Oct 19;37(3):109867
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:26935949 - Phosphorylation of the amino-terminus of the AGC kinase Gad8 prevents its interaction with TORC2.
Du W et al. Open Biol 2016 Mar;6(3)
PMID:25590601 - Fission yeast Ryh1 GTPase activates TOR Complex 2 in response to glucose.
Hatano T et al. Cell Cycle 2015;14(6):848-56
PMID:17121544 - Fission yeast Tor2 links nitrogen signals to cell proliferation and acts downstream of the Rheb GTPase.
Uritani M et al. Genes Cells 2006 Dec;11(12):1367-79
PMID:29079657 - TORC1 and TORC2 converge to regulate the SAGA co-activator in response to nutrient availability.
Laboucarié T et al. EMBO Rep 2017 Dec;18(12):2197-2218
PMID:25411338 - Mechanisms of expression and translocation of major fission yeast glucose transporters regulated by CaMKK/phosphatases, nuclear shuttling, and TOR.
Saitoh S et al. Mol Biol Cell 2015 Jan 15;26(2):373-86
PMID:12805221 - Schizosaccharomyces pombe AGC family kinase Gad8p forms a conserved signaling module with TOR and PDK1-like kinases.
Matsuo T et al. EMBO J 2003 Jun 16;22(12):3073-83
PMID:24928510 - Glucose activates TORC2-Gad8 protein via positive regulation of the cAMP/cAMP-dependent protein kinase A (PKA) pathway and negative regulation of the Pmk1 protein-mitogen-activated protein kinase pathway.
Cohen A et al. J Biol Chem 2014 Aug 01;289(31):21727-37
PMID:31456006 - Leucine depletion extends the lifespans of leucine-auxotrophic fission yeast by inducing Ecl1 family genes via the transcription factor Fil1.
Ohtsuka H et al. Mol Genet Genomics 2019 Dec;294(6):1499-1509
PMID:15466417 - Regulation of leucine uptake by tor1+ in Schizosaccharomyces pombe is sensitive to rapamycin.
Weisman R et al. Genetics 2005 Feb;169(2):539-50
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:25416816 - Multiple layers of regulation influence cell integrity control by the PKC ortholog Pck2 in fission yeast.
Madrid M et al. J Cell Sci 2015 Jan 15;128(2):266-80
PMID:26152587 - TORC1 Regulates Developmental Responses to Nitrogen Stress via Regulation of the GATA Transcription Factor Gaf1.
Laor D et al. mBio 2015 Jul 07;6(4):e00959
PMID:27191590 - Fission Yeast SCYL1/2 Homologue Ppk32: A Novel Regulator of TOR Signalling That Governs Survival during Brefeldin A Induced Stress to Protein Trafficking.
Kowalczyk KM et al. PLoS Genet 2016 May;12(5):e1006041
PMID:34984977 - Functional profiling of long intergenic non-coding RNAs in fission yeast.
Rodriguez-Lopez M et al. Elife 2022 Jan 05;11
PMID:22645648 - The reverse, but coordinated, roles of Tor2 (TORC1) and Tor1 (TORC2) kinases for growth, cell cycle and separase-mediated mitosis in Schizosaccharomyces pombe.
Ikai N et al. Open Biol 2011 Nov;1(3):110007
PMID:38780300 - Nitrogen availability is important for preventing catastrophic mitosis in fission yeast.
Zemlianski V et al. J Cell Sci 2024 May 23;
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:21625337 - Rab small GTPase emerges as a regulator of TOR complex 2.
Tatebe H et al. Small GTPases 2010 Nov;1(3):180-182
PMID:29852001 - New insights into donor directionality of mating-type switching in Schizosaccharomyces pombe.
Maki T et al. PLoS Genet 2018 May;14(5):e1007424
PMID:18076573 - Rapamycin sensitivity of the Schizosaccharomyces pombe tor2 mutant and organization of two highly phosphorylated TOR complexes by specific and common subunits.
Hayashi T et al. Genes Cells 2007 Dec;12(12):1357-70
PMID:32441227 - Glucose limitation and pka1 deletion rescue aberrant mitotic spindle formation induced by Mal3 overexpression in Schizosaccharomyces pombe .
Tanabe T et al. Biosci Biotechnol Biochem 2020 Aug;84(8):1667-1680
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:24344203 - Isp7 is a novel regulator of amino acid uptake in the TOR signaling pathway.
Laor D et al. Mol Cell Biol 2014 Mar;34(5):794-806
PMID:33574613 - TOR targets an RNA processing network to regulate facultative heterochromatin, developmental gene expression and cell proliferation.
Wei Y et al. Nat Cell Biol 2021 Mar;23(3):243-256
PMID:11872168 - Genes for a nuclease and a protease are involved in the drastic decrease in cellular RNA amount in fission yeast cells during nitrogen starvation.
Nakashima A et al. J Biochem 2002 Mar;131(3):391-8
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:26443240 - PKA antagonizes CLASP-dependent microtubule stabilization to re-localize Pom1 and buffer cell size upon glucose limitation.
Kelkar M et al. Nat Commun 2015 Oct 07;6:8445
PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134
PMID:35157728 - TOR complex 2 contributes to regulation of gene expression via inhibiting Gcn5 recruitment to subtelomeric and DNA replication stress genes.
Cohen A et al. PLoS Genet 2022 Feb;18(2):e1010061
PMID:39540318 - Pck2 association with the plasma membrane and efficient response of the cell integrity pathway require regulation of PI4P homeostasis by exomer.
Moscoso-Romero E et al. Open Biol 2024 Nov;14(11):240101
PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.
Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160
PMID:23640107 - Screening for long-lived genes identifies Oga1, a guanine-quadruplex associated protein that affects the chronological lifespan of the fission yeast Schizosaccharomyces pombe.
Ohtsuka H et al. Mol Genet Genomics 2013 Jun;288(5-6):285-95
PMID:17179073 - Opposite effects of tor1 and tor2 on nitrogen starvation responses in fission yeast.
Weisman R et al. Genetics 2007 Mar;175(3):1153-62
PMID:17952063 - TOR signalling regulates mitotic commitment through the stress MAP kinase pathway and the Polo and Cdc2 kinases.
Petersen J et al. Nat Cell Biol 2007 Nov;9(11):1263-72
PMID:29632066 - TOR complex 2 in fission yeast is required for chromatin-mediated gene silencing and assembly of heterochromatic domains at subtelomeres.
Cohen A et al. J Biol Chem 2018 May 25;293(21):8138-8150
PMID:22084378 - Nutrient limitations alter cell division control and chromosome segregation through growth-related kinases and phosphatases.
Yanagida M et al. Philos Trans R Soc Lond B Biol Sci 2011 Dec 27;366(1584):3508-20
PMID:28357272 - A central role for TOR signalling in a yeast model for juvenile CLN3 disease.
Bond ME et al. Microb Cell 2015 Nov 11;2(12):466-480
PMID:33105893 - Cadmium-Induced Cell Homeostasis Impairment is Suppressed by the Tor1 Deficiency in Fission Yeast.
Požgajová M et al. Int J Mol Sci 2020 Oct 22;21(21)
PMID:19417002 - Fission yeast Tor1 functions as part of TORC1 to control mitotic entry through the stress MAPK pathway following nutrient stress.
Hartmuth S et al. J Cell Sci 2009 Jun 01;122(Pt 11):1737-46
PMID:23551936 - TORC1 signaling inhibition by rapamycin and caffeine affect lifespan, global gene expression, and cell proliferation of fission yeast.
Rallis C et al. Aging Cell 2013 Aug;12(4):563-73
PMID:19620394 - Distinctive responses to nitrogen starvation in the dominant active mutants of the fission yeast Rheb GTPase.
Murai T et al. Genetics 2009 Oct;183(2):517-27
PMID:22160596 - Altered nuclear tRNA metabolism in La-deleted Schizosaccharomyces pombe is accompanied by a nutritional stress response involving Atf1p and Pcr1p that is suppressible by Xpo-t/Los1p.
Cherkasova V et al. Mol Biol Cell 2012 Feb;23(3):480-91
PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.
Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85
PMID:20144990 - Fission yeast TORC1 regulates phosphorylation of ribosomal S6 proteins in response to nutrients and its activity is inhibited by rapamycin.
Nakashima A et al. J Cell Sci 2010 Mar 01;123(Pt 5):777-86
PMID:27918601 - Identifying genes required for respiratory growth of fission yeast.
Malecki M et al. Wellcome Open Res 2016;1:12
PMID:25803873 - Calnexin is essential for survival under nitrogen starvation and stationary phase in Schizosaccharomyces pombe.
Núñez A et al. PLoS One 2015;10(3):e0121059
PMID:34296454 - The TOR-dependent phosphoproteome and regulation of cellular protein synthesis.
Mak T et al. EMBO J 2021 Aug 16;40(16):e107911
PMID:33137119 - TOR Complex 2- independent mutations in the regulatory PIF pocket of Gad8AKT1/SGK1 define separate branches of the stress response mechanisms in fission yeast.
Pataki E et al. PLoS Genet 2020 Nov;16(11):e1009196
PMID:11096119 - The fission yeast TOR homolog, tor1+, is required for the response to starvation and other stresses via a conserved serine.
Weisman R et al. J Biol Chem 2001 Mar 09;276(10):7027-32
PMID:34458935 - Nickel induced cell impairments are negatively regulated by the Tor1 kinase in Schizosaccharomyces pombe.
Navratilova A et al. World J Microbiol Biotechnol 2021 Aug 30;37(10):165
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:35820914 - Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging.
Vega M et al. BMC Biol 2022 Jul 12;20(1):160
PMID:17261596 - Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast.
Matsuo T et al. Mol Cell Biol 2007 Apr;27(8):3154-64
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:41227381 - The BUD31 Homologous Gene in Schizosaccharomyces pombe Is Evolutionarily Conserved and Can Be Linked to Cellular Processes Regulated by the TOR Pathway.
Vig I et al. Cells 2025 Nov 05;14(21)
PMID:41258116 - TORC2 inactivation promotes heterochromatin formation in rDNA and prolongs viability of quiescent fission yeast cells.
Hirai H et al. Commun Biol 2025 Nov 19;8(1):1606
PMID:28041796 - A PP2A-B55-Mediated Crosstalk between TORC1 and TORC2 Regulates the Differentiation Response in Fission Yeast.
Martín R et al. Curr Biol 2017 Jan 23;27(2):175-188
PMID:24247430 - Phosphorylation of the TOR ATP binding domain by AGC kinase constitutes a novel mode of TOR inhibition.
Hálová L et al. J Cell Biol 2013 Nov 25;203(4):595-604
PMID:17295836 - Fission yeast autophagy induced by nitrogen starvation generates a nitrogen source that drives adaptation processes.
Kohda TA et al. Genes Cells 2007 Feb;12(2):155-70
PMID:16550352 - A starvation-specific serine protease gene, isp6+, is involved in both autophagy and sexual development in Schizosaccharomyces pombe.
Nakashima A et al. Curr Genet 2006 Jun;49(6):403-13
PMID:19546237 - TOR complex 2 controls gene silencing, telomere length maintenance, and survival under DNA-damaging conditions.
Schonbrun M et al. Mol Cell Biol 2009 Aug;29(16):4584-94
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:27206859 - TOR complex 2 localises to the cytokinetic actomyosin ring and controls the fidelity of cytokinesis.
Baker K et al. J Cell Sci 2016 Jul 01;129(13):2613-24
PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.
Rallis C et al. Sci Rep 2017 Mar 10;7:44257
PMID:23703609 - TORC2 is required to maintain genome stability during S phase in fission yeast.
Schonbrun M et al. J Biol Chem 2013 Jul 05;288(27):19649-60
PMID:23826334 - Deletion of the fission yeast homologue of human insulinase reveals a TORC1-dependent pathway mediating resistance to proteotoxic stress.
Beuzelin C et al. PLoS One 2013;8(6):e67705
PMID:26912660 - Gad8 Protein Is Found in the Nucleus Where It Interacts with the MluI Cell Cycle Box-binding Factor (MBF) Transcriptional Complex to Regulate the Response to DNA Replication Stress.
Cohen A et al. J Biol Chem 2016 Apr 22;291(17):9371-81
PMID:31641022 - The cytosolic form of aspartate aminotransferase is required for full activation of TOR complex 1 in fission yeast.
Reidman S et al. J Biol Chem 2019 Nov 29;294(48):18244-18255
PMID:21035342 - Rab-family GTPase regulates TOR complex 2 signaling in fission yeast.
Tatebe H et al. Curr Biol 2010 Nov 23;20(22):1975-82
PMID:38971312 - TORC2 is required for accumulation of γH2A in response to DNA damage.
Cohen A et al. J Biol Chem 2024 Jul 04;:107531
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:29699848 - Phosphorylation of Wat1, human Lst8 homolog is critical for the regulation of TORC2 -Gad8 dependent pathway in fission yeast Schizosacchromyces pombe.
Ahamad N et al. Eur J Cell Biol 2018 May;97(4):300-307
PMID:21307597 - Ecl1, a regulator of the chronological lifespan of Schizosaccharomyces pombe, is induced upon nitrogen starvation.
Miwa Y et al. Biosci Biotechnol Biochem 2011;75(2):279-83
PMID:25972440 - Global regulation of heterochromatin spreading by Leo1.
Verrier L et al. Open Biol 2015 May;5(5)
PMID:41501458 - Stress controls heterochromatin inheritance via histone H3 ubiquitylation.
Bhatt B et al. Nature 2026 Jan 07;
PMID:21965528 - Aurora promotes cell division during recovery from TOR-mediated cell cycle arrest by driving spindle pole body recruitment of Polo.
Hálová L et al. J Cell Sci 2011 Oct 15;124(Pt 20):3441-9
PMID:23074192 - Pmt1, a Dnmt2 homolog in Schizosaccharomyces pombe, mediates tRNA methylation in response to nutrient signaling.
Becker M et al. Nucleic Acids Res 2012 Dec;40(22):11648-58
PMID:18235227 - Fission yeast TOR complex 2 activates the AGC-family Gad8 kinase essential for stress resistance and cell cycle control.
Ikeda K et al. Cell Cycle 2008 Feb 01;7(3):358-64
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:28264193 - Substrate specificity of TOR complex 2 is determined by a ubiquitin-fold domain of the Sin1 subunit.
Tatebe H et al. Elife 2017 Mar 07;6