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protein coding gene - tor1 (SPBC30D10.10c) - TORC2 serine/threonine protein kinase Tor1

Gene summary

Standard name
tor1
Systematic ID
SPBC30D10.10c
Product
TORC2 serine/threonine protein kinase Tor1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O14356
ORFeome ID
48/48H11
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 3075748..3083248 forward strand

Annotation

PBO:0002663 - 2.7.1.137

Disease association

MONDO:0011818 - isolated focal cortical dysplasia type II

References:

MONDO:0014716 - macrocephaly-intellectual disability-neurodevelopmental disorder-small thorax syndrome

References:

MONDO:0100283 - overgrowth syndrome and/or cerebral malformations due to abnormalities in MTOR pathway genes

References:

GO biological process

GO:0010972 - negative regulation of G2/M transition of mitotic cell cycle

References:

GO:0061188 - negative regulation of rDNA heterochromatin formation

References:

GO:0000122 - negative regulation of transcription by RNA polymerase II

References:

GO:0010971 - positive regulation of G2/M transition of mitotic cell cycle

References:

GO:1900237 - positive regulation of induction of conjugation with cellular fusion

References:

GO:0045944 - positive regulation of transcription by RNA polymerase II

References:

GO:0038203 - TORC2 signaling

References:

GO cellular component

GO:0000785 - chromatin

References:

GO:0005737 - cytoplasm

References:

GO:0005829 - cytosol

References:

GO:0030874 - nucleolar chromatin

References:

GO:0031932 - TORC2 complex

References:

GO molecular function

GO:0005515 - protein binding

References:

GO:0004672 - protein kinase activity

References:

GO:0004674 - protein serine/threonine kinase activity

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

MOD:00696 - phosphorylated residue

References:

Multi-locus phenotype

FYPO:0000400 - abnormal cell cycle arrest at mitotic G2/M phase transition

References:

Genotypes:

FYPO:0000444 - abnormal mitotic cell cycle arrest with replicated DNA

References:

Genotypes:

FYPO:0001430 - abnormal mitotic cell cycle arrest with unreplicated DNA

References:

Genotypes:

FYPO:0004481 - abolished cell population growth at high temperature

References:

Genotypes:

FYPO:0000229 - cut

References:

Genotypes:

FYPO:0000082 - decreased cell population growth at high temperature

References:

Genotypes:

FYPO:0008378 - decreased histone H2A phosphorylation during cellular response to camptothecin

References:

Genotypes:

FYPO:0008379 - decreased histone H2A phosphorylation during nitrogen starvation

References:

Genotypes:

FYPO:0001140 - decreased leucine import

References:

Genotypes:

FYPO:0000708 - decreased mating efficiency

References:

Genotypes:

FYPO:0006470 - decreased mature rRNA level

References:

Genotypes:

FYPO:0005034 - decreased protein phosphorylation during nitrogen starvation

References:

Genotypes:

FYPO:0001838 - decreased protein phosphorylation during vegetative growth

References:

Genotypes:

FYPO:0002975 - decreased RNA level during cellular response to hydroxyurea

References:

Genotypes:

FYPO:0001117 - decreased RNA level during vegetative growth

References:

Genotypes:

FYPO:0004085 - decreased vegetative cell growth

References:

Genotypes:

FYPO:0002019 - elongated telomeres during vegetative growth

References:

Genotypes:

FYPO:0001122 - elongated vegetative cell

References:

Genotypes:

FYPO:0000761 - increased conjugation frequency

References:

Genotypes:

FYPO:0006074 - increased histone H3-K9 dimethylation at rDNA during vegetative growth

References:

Genotypes:

FYPO:0007526 - increased protein phosphorylation during cellular response to salt stress

References:

Genotypes:

FYPO:0001309 - increased viability in stationary phase

References:

Genotypes:

FYPO:0002262 - inviable after spore germination, multiple cell divisions, elongated cell

References:

Genotypes:

FYPO:0001490 - inviable elongated vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0000674 - normal cell population growth at high temperature

References:

Genotypes:

FYPO:0004765 - normal cell population growth during glucose starvation

References:

Genotypes:

FYPO:0003086 - normal chromatin binding

References:

Genotypes:

FYPO:0003555 - normal chromatin silencing at subtelomere

References:

Genotypes:

FYPO:0001021 - normal growth during cellular response to osmotic stress

References:

Genotypes:

FYPO:0001688 - normal growth on brefeldin A

References:

Genotypes:

FYPO:0000960 - normal growth on ethanol

References:

Genotypes:

FYPO:0001164 - normal growth on glucose carbon source

References:

Genotypes:

FYPO:0003809 - normal growth on latrunculin A

References:

Genotypes:

FYPO:0008380 - normal histone H2A phosphorylation during cellular response to camptothecin

References:

Genotypes:

FYPO:0006395 - normal histone H3-K9 acetylation at subtelomeric heterochromatin during vegetative growth

References:

Genotypes:

FYPO:0003223 - normal histone H3-K9 acetylation during vegetative growth

References:

Genotypes:

FYPO:0005572 - normal protein localization to cell periphery

References:

Genotypes:

FYPO:0003576 - normal protein localization to subtelomeric heterochromatin

References:

Genotypes:

FYPO:0004422 - normal protein phosphorylation

References:

Genotypes:

FYPO:0005602 - normal subtelomeric heterochromatin RNA level

References:

Genotypes:

FYPO:0006742 - normal transcription from MCB promoter

References:

Genotypes:

FYPO:0001032 - resistance to camptothecin

References:

Genotypes:

FYPO:0002578 - resistance to hydroxyurea

References:

Genotypes:

FYPO:0001501 - sensitive to brefeldin A

References:

Genotypes:

FYPO:0000098 - sensitive to calcium

References:

Genotypes:

FYPO:0000085 - sensitive to camptothecin

References:

Genotypes:

FYPO:0000099 - sensitive to canavanine

References:

Genotypes:

FYPO:0000081 - sensitive to high osmolarity

References:

Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

References:

Genotypes:

FYPO:0001525 - sensitive to L-thialysine

References:

Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

References:

Genotypes:

FYPO:0000111 - sensitive to rapamycin

References:

Genotypes:

FYPO:0000271 - sensitive to salt stress

References:

Genotypes:

FYPO:0000091 - sensitive to thiabendazole

References:

Genotypes:

FYPO:0002239 - shortened telomeres during vegetative growth

References:

Genotypes:

FYPO:0002788 - small vacuoles during vegetative growth

References:

Genotypes:

FYPO:0000280 - sterile

References:

Genotypes:

FYPO:0001492 - viable elongated vegetative cell

References:

Genotypes:

FYPO:0003481 - viable elongated vegetative cell, elongated upon mitotic entry

References:

Genotypes:

FYPO:0006822 - viable small vegetative cell with normal cell growth rate

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0004840 - abnormal high-affinity glucose import

References:

Genotypes:

FYPO:0000710 - abnormal mitotic cell cycle arrest in response to nitrogen starvation

References:

Genotypes:

FYPO:0005189 - abnormal re-entry into mitotic cell cycle after arrest in response to hydroxyurea

References:

Genotypes:

FYPO:0003345 - abolished cell cycle arrest in mitotic G1 phase in response to nitrogen starvation

References:

Genotypes:

FYPO:0004481 - abolished cell population growth at high temperature

References:

Genotypes:

FYPO:0003255 - abolished proline import

References:

Genotypes:

FYPO:0001384 - abolished protein kinase activity

References:

Genotypes:

FYPO:0005571 - abolished protein localization to cell periphery during vegetative growth

References:

Genotypes:

FYPO:0004839 - abolished protein localization to plasma membrane, with protein mislocalized to cytoplasm, during glucose starvation

References:

Genotypes:

FYPO:0002678 - abolished protein phosphorylation

References:

Genotypes:

FYPO:0002033 - abolished protein phosphorylation during vegetative growth

References:

Genotypes:

FYPO:0000705 - abolished protein-protein interaction

References:

Genotypes:

FYPO:0003425 - abolished protein-protein interaction during cellular response to rapamycin

References:

Genotypes:

FYPO:0002133 - abolished protein-RNA interaction

References:

Genotypes:

FYPO:0000583 - abolished sporulation

References:

Genotypes:

FYPO:0005430 - aggregated actin cortical patches during vegetative growth

References:

Genotypes:

FYPO:0000711 - decreased cell cycle arrest in mitotic G1 phase in response to nitrogen starvation

References:

Genotypes:

FYPO:0001187 - decreased cell density in stationary phase

References:

Genotypes:

FYPO:0000082 - decreased cell population growth at high temperature

References:

Genotypes:

FYPO:0000080 - decreased cell population growth at low temperature

References:

Genotypes:

FYPO:0003743 - decreased cell population growth during glucose starvation

References:

Genotypes:

FYPO:0009078 - decreased cell population growth on ethanol carbon source

References:

Genotypes:

FYPO:0000251 - decreased cell population growth on galactose carbon source

References:

Genotypes:

FYPO:0001407 - decreased cell population growth on glucose carbon source

References:

Genotypes:

FYPO:0009053 - decreased cell population growth on glutamate nitrogen source

References:

Genotypes:

FYPO:0009100 - decreased cell population growth on glycerol and galactose carbon source

References:

Genotypes:

FYPO:0000684 - decreased cell population growth on glycerol carbon source

References:

Genotypes:

FYPO:0009091 - decreased cell population growth on lysine and proline nitrogen source

References:

Genotypes:

FYPO:0002924 - decreased cell population growth on maltose carbon source

References:

Genotypes:

FYPO:0009099 - decreased cell population growth on mannitol carbon source

References:

Genotypes:

FYPO:0009097 - decreased cell population growth on xylose carbon source

References:

Genotypes:

FYPO:0002827 - decreased chromatin silencing at silent mating-type cassette

References:

Genotypes:

FYPO:0004604 - decreased chromatin silencing at subtelomere

References:

Genotypes:

FYPO:0002340 - decreased DNA recombination during vegetative growth

References:

Genotypes:

FYPO:0000185 - decreased gene conversion during vegetative growth

References:

Genotypes:

FYPO:0006549 - decreased gene expression

References:

Genotypes:

FYPO:0008378 - decreased histone H2A phosphorylation during cellular response to camptothecin

References:

Genotypes:

FYPO:0008438 - decreased histone H2A phosphorylation during cellular response to methyl methanesulfonate

References:

Genotypes:

FYPO:0008379 - decreased histone H2A phosphorylation during nitrogen starvation

References:

Genotypes:

FYPO:0004137 - decreased histone H3-K9 dimethylation at subtelomeric heterochromatin during vegetative growth

References:

Genotypes:

FYPO:0006753 - decreased histone H4-K20 dimethylation at subtelomeric heterochromatin during vegetative growth

References:

Genotypes:

FYPO:0001140 - decreased leucine import

References:

Genotypes:

FYPO:0005187 - decreased level of transport gene mRNA during vegetative growth

References:

Genotypes:

FYPO:0000708 - decreased mating efficiency

References:

Genotypes:

FYPO:0000470 - decreased mating type switching

References:

Genotypes:

FYPO:0001382 - decreased protein kinase activity

References:

Genotypes:

FYPO:0004194 - decreased protein level during cellular response to hydroxyurea

References:

Genotypes:

FYPO:0001324 - decreased protein level during vegetative growth

References:

Genotypes:

FYPO:0002976 - decreased protein localization to chromatin at MCB promoters during cellular response to hydroxyurea

References:

Genotypes:

FYPO:0005314 - decreased protein localization to chromatin at MCB promoters during vegetative growth

References:

Genotypes:

FYPO:0002391 - decreased protein localization to chromatin at rDNA

References:

Genotypes:

FYPO:0002387 - decreased protein localization to subtelomeric heterochromatin during vegetative growth

References:

Genotypes:

FYPO:0002679 - decreased protein phosphorylation

References:

Genotypes:

FYPO:0005034 - decreased protein phosphorylation during nitrogen starvation

References:

Genotypes:

FYPO:0001838 - decreased protein phosphorylation during vegetative growth

References:

Genotypes:

FYPO:0006494 - decreased rDNA copy number during vegetative growth

References:

Genotypes:

FYPO:0002975 - decreased RNA level during cellular response to hydroxyurea

References:

Genotypes:

FYPO:0001152 - decreased RNA level during nitrogen starvation

References:

Genotypes:

FYPO:0001117 - decreased RNA level during vegetative growth

References:

Genotypes:

FYPO:0004009 - decreased rRNA transcription

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0008128 - decreased vegetative cell population growth on low glucose

References:

Genotypes:

FYPO:0009007 - decreased vegetative cell population viability

References:

Genotypes:

FYPO:0005188 - delayed onset of mitotic cell cycle arrest during cellular response to hydroxyurea

References:

Genotypes:

FYPO:0002830 - delayed onset of protein phosphorylation during vegetative growth

References:

Genotypes:

FYPO:0004427 - delayed onset of ribosomal S6 protein dephosphorylation during cellular response to nitrogen starvation

References:

Genotypes:

FYPO:0000017 - elongated cell

References:

Genotypes:

FYPO:0005077 - elongated cell during glucose starvation

References:

Genotypes:

FYPO:0000998 - elongated cell during nitrogen starvation

References:

Genotypes:

FYPO:0003160 - elongated cell during stationary phase

References:

Genotypes:

FYPO:0002019 - elongated telomeres during vegetative growth

References:

Genotypes:

FYPO:0001122 - elongated vegetative cell

References:

Genotypes:

FYPO:0005261 - increased cell population growth on galactose carbon source

References:

Genotypes:

FYPO:0009011 - increased cell population viability on galactose carbon source

References:

Genotypes:

FYPO:0009016 - increased cell population viability on xylose carbon source

References:

Genotypes:

FYPO:0002341 - increased duration of mitotic DNA damage checkpoint

References:

Genotypes:

FYPO:0006751 - increased histone H3-K4 trimethylation at subtelomeric heterochromatin during vegetative growth

References:

Genotypes:

FYPO:0004575 - increased histone H3-K9 acetylation at subtelomere during vegetative growth

References:

Genotypes:

FYPO:0006074 - increased histone H3-K9 dimethylation at rDNA during vegetative growth

References:

Genotypes:

FYPO:0003746 - increased histone H3-K9 methylation at heterochromatin island during vegetative growth

References:

Genotypes:

FYPO:0006077 - increased histone H3-K9 methylation at rDNA during vegetative growth

References:

Genotypes:

FYPO:0005316 - increased histone H4-K12 acetylation at subtelomere during vegetative growth

References:

Genotypes:

FYPO:0006752 - increased histone H4-K16 acetylation at subtelomeric heterochromatin during vegetative growth

References:

Genotypes:

FYPO:0000972 - increased number of Rad52 foci during vegetative growth

References:

Genotypes:

FYPO:0000847 - increased protein degradation during vegetative growth

References:

Genotypes:

FYPO:0002700 - increased protein kinase activity

References:

Genotypes:

FYPO:0001327 - increased protein level during vegetative growth

References:

Genotypes:

FYPO:0002852 - increased protein localization to cell tip during vegetative growth

References:

Genotypes:

FYPO:0006740 - increased protein localization to chromatin at MCB promoters during vegetative growth

References:

Genotypes:

FYPO:0004032 - increased protein localization to chromatin at rDNA

References:

Genotypes:

FYPO:0006552 - increased protein localization to cytoplasm

References:

Genotypes:

FYPO:0003010 - increased protein localization to subtelomeric heterochromatin during vegetative growth

References:

Genotypes:

FYPO:0002680 - increased protein phosphorylation

References:

Genotypes:

FYPO:0007526 - increased protein phosphorylation during cellular response to salt stress

References:

Genotypes:

FYPO:0002681 - increased protein phosphorylation during nitrogen starvation

References:

Genotypes:

FYPO:0001038 - increased protein phosphorylation during vegetative growth

References:

Genotypes:

FYPO:0002082 - increased protein ubiquitination during vegetative growth

References:

Genotypes:

FYPO:0000650 - increased septation index

References:

Genotypes:

FYPO:0005917 - increased subtelomeric heterochromatin RNA level

References:

Genotypes:

FYPO:0009008 - increased vegetative cell population viability

References:

Genotypes:

FYPO:0001309 - increased viability in stationary phase

References:

Genotypes:

FYPO:0004163 - increased viability upon glucose starvation

References:

Genotypes:

FYPO:0004343 - increased wtf-derived RNA level

References:

Genotypes:

FYPO:0001490 - inviable elongated vegetative cell

References:

Genotypes:

FYPO:0004104 - inviable spherical vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0000245 - loss of viability in stationary phase

References:

Genotypes:

FYPO:0005231 - loss of viability in stationary phase upon glucose starvation

References:

Genotypes:

FYPO:0000339 - mislocalized septum during vegetative growth

References:

Genotypes:

FYPO:0000012 - mitotic G2/M phase transition delay

References:

Genotypes:

FYPO:0001019 - monopolar actin cortical patch localization during vegetative growth

References:

Genotypes:

FYPO:0004652 - normal actomyosin contractile ring morphology

References:

Genotypes:

FYPO:0000674 - normal cell population growth at high temperature

References:

Genotypes:

FYPO:0001925 - normal cellular response to gamma radiation

References:

Genotypes:

FYPO:0002567 - normal centromeric outer repeat transcript level

References:

Genotypes:

FYPO:0002360 - normal chromatin silencing at centromere

References:

Genotypes:

FYPO:0006142 - normal G0 to G1 transition

References:

Genotypes:

FYPO:0001037 - normal growth during cellular response to salt stress

References:

Genotypes:

FYPO:0001020 - normal growth on calcium

References:

Genotypes:

FYPO:0001164 - normal growth on glucose carbon source

References:

Genotypes:

FYPO:0002672 - normal growth on rapamycin

References:

Genotypes:

FYPO:0000961 - normal growth on sorbitol

References:

Genotypes:

FYPO:0000862 - normal histone H3-K9 dimethylation at centromere during vegetative growth

References:

Genotypes:

FYPO:0002259 - normal leucine import

References:

Genotypes:

FYPO:0002801 - normal protein degradation during nitrogen starvation

References:

Genotypes:

FYPO:0005168 - normal protein level during cellular response to salt stress

References:

Genotypes:

FYPO:0000833 - normal protein level during vegetative growth

References:

Genotypes:

FYPO:0001509 - normal protein localization to chromatin during vegetative growth

References:

Genotypes:

FYPO:0002625 - normal protein localization to chromatin rDNA

References:

Genotypes:

FYPO:0002389 - normal protein localization to heterochromatin at centromere outer repeat

References:

Genotypes:

FYPO:0007705 - normal protein localization to lateral cell cortex during glucose starvation

References:

Genotypes:

FYPO:0006554 - normal protein localization to nucleus during nitrogen starvation

References:

Genotypes:

FYPO:0002899 - normal protein phosphorylation during cellular response to DNA damage

References:

Genotypes:

FYPO:0002099 - normal protein phosphorylation during cellular response to hydroxyurea

References:

Genotypes:

FYPO:0001266 - normal protein phosphorylation during cellular response to salt stress

References:

Genotypes:

FYPO:0005035 - normal protein phosphorylation during nitrogen starvation

References:

Genotypes:

FYPO:0001668 - normal protein processing during vegetative growth

References:

Genotypes:

FYPO:0004423 - normal protein threonine phosphorylation

References:

Genotypes:

FYPO:0000703 - normal protein-protein interaction

References:

Genotypes:

FYPO:0002357 - normal protein-RNA interaction

References:

Genotypes:

FYPO:0003828 - normal ribosomal S6 protein phosphorylation during vegetative growth

References:

Genotypes:

FYPO:0001246 - normal RNA level during cellular response to hydrogen peroxide

References:

Genotypes:

FYPO:0001486 - normal RNA level during cellular response to salt stress

References:

Genotypes:

FYPO:0001096 - normal RNA level during nitrogen starvation

References:

Genotypes:

FYPO:0001317 - normal RNA level during vegetative growth

References:

Genotypes:

FYPO:0005602 - normal subtelomeric heterochromatin RNA level

References:

Genotypes:

FYPO:0001770 - normal tRNA methyltransferase activity

References:

Genotypes:

FYPO:0002085 - normal vegetative cell growth

References:

Genotypes:

FYPO:0001420 - normal vegetative cell population growth rate

References:

Genotypes:

FYPO:0001310 - normal viability in stationary phase

References:

Genotypes:

FYPO:0000441 - resistance to antimycin A

References:

Genotypes:

FYPO:0000073 - resistance to caffeine

References:

Genotypes:

FYPO:0001029 - resistance to canavanine

References:

Genotypes:

FYPO:0009047 - resistance to dimethyl sulfoxide

References:

Genotypes:

FYPO:0009038 - resistance to egtazic acid

References:

Genotypes:

FYPO:0001453 - resistance to ethanol

References:

Genotypes:

FYPO:0009034 - resistance to ethylenediaminetetraacetic acid

References:

Genotypes:

FYPO:0009035 - resistance to formamide

References:

Genotypes:

FYPO:0001103 - resistance to hydrogen peroxide

References:

Genotypes:

FYPO:0009050 - resistance to hydroxyurea and methyl methanesulfonate

References:

Genotypes:

FYPO:0004513 - resistance to latrunculin A

References:

Genotypes:

FYPO:0001583 - resistance to lithium

References:

Genotypes:

FYPO:0000725 - resistance to methyl methanesulfonate

References:

Genotypes:

FYPO:0009046 - resistance to phloxine B and hydrogen peroxide

References:

Genotypes:

FYPO:0009039 - resistance to potassium chloride

References:

Genotypes:

FYPO:0000077 - resistance to rapamycin

References:

Genotypes:

FYPO:0000852 - resistance to salt stress

References:

Genotypes:

FYPO:0005968 - resistance to sodium chloride

References:

Genotypes:

FYPO:0009042 - resistance to sorbitol

References:

Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

References:

Genotypes:

FYPO:0005193 - resistance to torin1

References:

Genotypes:

FYPO:0001034 - resistance to tunicamycin

References:

Genotypes:

FYPO:0000830 - resistance to vanadate

References:

Genotypes:

FYPO:0003161 - RNA absent from cell during vegetative growth

References:

Genotypes:

FYPO:0007933 - sensitive to 2,2′-dipyridyl

References:

Genotypes:

FYPO:0001097 - sensitive to amitrole

References:

Genotypes:

FYPO:0000095 - sensitive to bleomycin

References:

Genotypes:

FYPO:0001701 - sensitive to bortezomib

References:

Genotypes:

FYPO:0001501 - sensitive to brefeldin A

References:

Genotypes:

FYPO:0000096 - sensitive to cadmium

References:

Genotypes:

FYPO:0000097 - sensitive to caffeine during vegetative growth

References:

Genotypes:

FYPO:0000098 - sensitive to calcium

References:

Genotypes:

FYPO:0000085 - sensitive to camptothecin

References:

Genotypes:

FYPO:0000099 - sensitive to canavanine

References:

Genotypes:

FYPO:0000104 - sensitive to cycloheximide

References:

Genotypes:

FYPO:0000799 - sensitive to diamide

References:

Genotypes:

FYPO:0007931 - sensitive to egtazic acid

References:

Genotypes:

FYPO:0000842 - sensitive to ethanol during vegetative growth

References:

Genotypes:

FYPO:0007928 - sensitive to ethylenediaminetetraacetic acid

References:

Genotypes:

FYPO:0000785 - sensitive to formamide

References:

Genotypes:

FYPO:0001408 - sensitive to heat shock

References:

Genotypes:

FYPO:0000081 - sensitive to high osmolarity

References:

Genotypes:

FYPO:0001987 - sensitive to high pH

References:

Genotypes:

FYPO:0000087 - sensitive to hydrogen peroxide

References:

Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

References:

Genotypes:

FYPO:0009071 - sensitive to itraconazole

References:

Genotypes:

FYPO:0001525 - sensitive to L-thialysine

References:

Genotypes:

FYPO:0001719 - sensitive to lithium

References:

Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0006836 - sensitive to magnesium chloride

References:

Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

References:

Genotypes:

FYPO:0001214 - sensitive to potassium chloride

References:

Genotypes:

FYPO:0009082 - sensitive to potassium chloride and methyl methanesulfonate

References:

Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000111 - sensitive to rapamycin

References:

Genotypes:

FYPO:0000271 - sensitive to salt stress

References:

Genotypes:

FYPO:0007925 - sensitive to sodium chloride and methyl methanesulfonate

References:

Genotypes:

FYPO:0000841 - sensitive to sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000797 - sensitive to tert-butyl hydroperoxide

References:

Genotypes:

FYPO:0000091 - sensitive to thiabendazole

References:

Genotypes:

FYPO:0002546 - sensitive to trichostatin A

References:

Genotypes:

FYPO:0001457 - sensitive to tunicamycin

References:

Genotypes:

FYPO:0000268 - sensitive to UV during vegetative growth

References:

Genotypes:

FYPO:0000115 - sensitive to valproic acid

References:

Genotypes:

FYPO:0003656 - sensitive to vanadate

References:

Genotypes:

FYPO:0001234 - slow vegetative cell population growth

References:

Genotypes:

FYPO:0002788 - small vacuoles during vegetative growth

References:

Genotypes:

FYPO:0000280 - sterile

References:

Genotypes:

FYPO:0001492 - viable elongated vegetative cell

References:

Genotypes:

FYPO:0003481 - viable elongated vegetative cell, elongated upon mitotic entry

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF25574TPR_IMB1IMB1_TNPO1-like_TPRPFAM
PF02259FATPIK-rel_kinase_FATPFAM
PF23593HEAT_ATRHEAT_ATRPFAM
PF02260FATCFATC_domPFAM
PF08771FRB_domFRB_domPFAM
PF00454PI3_PI4_kinasePI3/4_kinase_cat_domPFAM
PF11865mTOR_dommTOR_domPFAM
cd05169PIKKc_TORTOR_catCDD
PS00915PI3_4_KINASE_1PI3/4_kinase_CSPROSITE_PATTERNS
PS00916PI3_4_KINASE_2PI3/4_kinase_CSPROSITE_PATTERNS
PS51189FATPIK_FATPROSITE_PROFILES
PS51190FATCFATC_domPROSITE_PROFILES
PS50290PI3_4_KINASE_3PI3/4_kinase_cat_domPROSITE_PROFILES
SM01345Rapamycin_bind_3SMART
SM01346DUF3385_3mTOR_domSMART
SM01343FATC_2FATC_domSMART
SM00146pi3k_hr1_6PI3/4_kinase_cat_domSMART
G3DSA:1.25.10.10:FF:000371FUNFAM
G3DSA:1.20.120.150:FF:000001FUNFAM
G3DSA:1.25.10.10:FF:000582FUNFAM
G3DSA:1.25.40.10:FF:003516FUNFAM
G3DSA:1.10.1070.11:FF:000007FUNFAM
G3DSA:3.30.1010.10:FF:000004FUNFAM
SSF47212FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)FRB_sfSUPERFAMILY
SSF48371ARM repeatARM-type_foldSUPERFAMILY
SSF56112Protein kinase-like (PK-like)Kinase-like_dom_sfSUPERFAMILY
G3DSA:1.25.40.10Tetratricopeptide repeat domainTPR-like_helical_dom_sfGENE3D
G3DSA:1.25.10.10ARM-likeGENE3D
G3DSA:1.20.120.150FRB_sfGENE3D
G3DSA:1.10.1070.11PI3/4_kinase_cat_sfGENE3D
G3DSA:3.30.1010.10GENE3D
PTHR11139ATAXIA TELANGIECTASIA MUTATED ATM -RELATEDDDR_Repair_KinasePANTHER

Orthologs

References / Literature

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PMID:31641022 - The cytosolic form of aspartate aminotransferase is required for full activation of TOR complex 1 in fission yeast.
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PMID:34028542 - TORC2 inhibition of α-arrestin Aly3 mediates cell surface persistence of S. pombe Ght5 glucose transporter in low glucose.
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PMID:20144990 - Fission yeast TORC1 regulates phosphorylation of ribosomal S6 proteins in response to nutrients and its activity is inhibited by rapamycin.
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PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
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PMID:21035342 - Rab-family GTPase regulates TOR complex 2 signaling in fission yeast.
Tatebe H et al. Curr Biol 2010 Nov 23;20(22):1975-82
PMID:16550352 - A starvation-specific serine protease gene, isp6+, is involved in both autophagy and sexual development in Schizosaccharomyces pombe.
Nakashima A et al. Curr Genet 2006 Jun;49(6):403-13
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Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:24928510 - Glucose activates TORC2-Gad8 protein via positive regulation of the cAMP/cAMP-dependent protein kinase A (PKA) pathway and negative regulation of the Pmk1 protein-mitogen-activated protein kinase pathway.
Cohen A et al. J Biol Chem 2014 Aug 01;289(31):21727-37
PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.
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PMID:32441227 - Glucose limitation and pka1 deletion rescue aberrant mitotic spindle formation induced by Mal3 overexpression in Schizosaccharomyces pombe .
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PMID:29632066 - TOR complex 2 in fission yeast is required for chromatin-mediated gene silencing and assembly of heterochromatic domains at subtelomeres.
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PMID:29079657 - TORC1 and TORC2 converge to regulate the SAGA co-activator in response to nutrient availability.
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