protein coding gene - naf1 (SPBC30D10.15) - snoRNP assembly factor Naf1

Gene summary

Standard name: naf1
Systematic ID: SPBC30D10.15
Product: snoRNP assembly factor Naf1
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: O14360
ORFeome ID: 25/25B07
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome II: 3065905..3067547 reverse strand

Annotation

Disease association

MONDO:0957261 - pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 7

References:

PB_REF:0000006

GO biological process

GO:0000493 - box H/ACA snoRNP assembly

References:

GO_REF:0000033

GO:0001522 - pseudouridine synthesis

References:

GO_REF:0000002

GO:0006364 - rRNA processing

References:

GO_REF:0000111

GO cellular component

GO:0005635 - nuclear envelope

References:

PMID:16823372

GO:0005654 - nucleoplasm

References:

GO_REF:0000024

GO:0005634 - nucleus

References:

PMID:16823372

GO:0005732 - sno(s)RNA-containing ribonucleoprotein complex

References:

GO_REF:0000033

GO molecular function

GO:0030515 - snoRNA binding

References:

GO_REF:0000050

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

MOD:00696 - phosphorylated residue

References:

PMID:19547744

MOD:01148 - ubiquitinylated lysine

References:

PMID:37970674

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PMID:39367033

PomGeneEx:0000012 - RNA level decreased

References:

PMID:33313903

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0000059 - abnormal mitotic cell cycle

References:

PMID:23697806

Genotypes:

naf1delta

FYPO:0001490 - inviable elongated vegetative cell

References:

PMID:23697806

Genotypes:

naf1delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

naf1delta

FYPO:0001511 - inviable vegetative cell, abnormal cell shape, normal cell size

References:

PMID:23697806

Genotypes:

naf1delta

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF04410	Gar1	H/ACA_rnp_Gar1/Naf1	PFAM
G3DSA:2.40.10.230:FF:000002			FUNFAM
SSF50447	Translation proteins	Transl_B-barrel_sf	SUPERFAMILY
G3DSA:2.40.10.230	Probable tRNA pseudouridine synthase domain	Gar1/Naf1_Cbf5-bd_sf	GENE3D
PTHR31633	H/ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1	Naf1	PANTHER
mobidb-lite-Disorder	disorder_prediction		MOBIDB-Disorder
mobidb-lite-Low-complexity	disorder_prediction		MOBIDB-Low-complexity
mobidb-lite-Polar	disorder_prediction		MOBIDB-Polar

Orthologs

NAF1 (HGNC:25126) Homo sapiens
naf1 (SJAG_03125) Schizosaccharomyces japonicus
NAF1 (YNL124W) Saccharomyces cerevisiae

References / Literature

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.: Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.: Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.: Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134
PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.: Egan ED et al. RNA 2014 Jun;20(6):867-81
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.: Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:32062975 - Phosphoproteomics Reveals Novel Targets and Phosphoprotein Networks in Cell Cycle Mediated by Dsk1 Kinase.: Wu M et al. J Proteome Res 2020 Apr 03;19(4):1776-1787
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.: Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
GO_REF:0000050 - Manual transfer of GO annotation data to genes by curator judgment of sequence model
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.: Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:18257517 - Phosphoproteome analysis of fission yeast.: Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.: Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.: Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.: Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.: Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
GO_REF:0000002 - Comments
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7