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protein coding gene - mzm1 (SPBC30D10.21) - mitochondrial respiratory chain complex III assembly protein, LYR family Mzm1

Gene summary

Standard name
mzm1
Systematic ID
SPBC30D10.21
Product
mitochondrial respiratory chain complex III assembly protein, LYR family Mzm1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
new18
UniProt ID
G2TRP8
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 3089021..3089634 forward strand

Annotation

Disease association

MONDO:0004069 - inborn mitochondrial metabolism disorder

References:

MONDO:0005066 - metabolic disease

References:

MONDO:0015448 - mitochondrial complex III deficiency

References:

MONDO:0014364 - mitochondrial complex III deficiency nuclear type 8

References:

GO biological process

GO:0034551 - mitochondrial respiratory chain complex III assembly

References:

GO:0006457 - protein folding

References:

GO cellular component

GO:0005759 - mitochondrial matrix

References:

GO molecular function

GO:0044183 - protein folding chaperone

References:

Protein features

PBO:0111754 - LYR family

Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0009072 - increased cell population growth on lysine nitrogen source

References:

Genotypes:

FYPO:0000764 - resistance to cycloheximide

References:

Genotypes:

FYPO:0002693 - resistance to diamide

References:

Genotypes:

FYPO:0009038 - resistance to egtazic acid

References:

Genotypes:

FYPO:0001453 - resistance to ethanol

References:

Genotypes:

FYPO:0009035 - resistance to formamide

References:

Genotypes:

FYPO:0009083 - resistance to lithium chloride and methyl methanesulfonate

References:

Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0007808 - resistance to valproic acid

References:

Genotypes:

FYPO:0000830 - resistance to vanadate

References:

Genotypes:

FYPO:0000797 - sensitive to tert-butyl hydroperoxide

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000082 - new gene

References:

Protein features

IDNameInterPro nameDB name
cd20267Complex1_LYR_LYRM7Complex1_LYR_LYRM7CDD
PTHR46749MZM1/LYRM7PANTHER
CoilCOILS

Orthologs

References / Literature

PMID:21270388 - Augmented annotation of the Schizosaccharomyces pombe genome reveals additional genes required for growth and viability.
Bitton DA et al. Genetics 2011 Apr;187(4):1207-17
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
GO_REF:0000108 - Automatic assignment of GO terms using logical inference, based on on inter-ontology links.
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:26896847 - Ensembl comparative genomics resources.
Herrero J et al. Database (Oxford) 2016;2016
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PB_REF:0000003 - Disease Association Curation
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12