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protein coding gene - hub1 (SPBC31E1.03) - ubiquitin-like protein modifier Hub1

Gene summary

Standard name
hub1
Systematic ID
SPBC31E1.03
Product
ubiquitin-like protein modifier Hub1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
ubl4
UniProt ID
O94650
ORFeome ID
02/02A09
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 243966..244982 reverse strand

Annotation

GO biological process

GO:0045292 - mRNA cis splicing, via spliceosome

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GO cellular component

GO:0005737 - cytoplasm

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GO:0005829 - cytosol

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GO:0005634 - nucleus

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GO molecular function

GO:0031386 - protein tag activity

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Modification

MOD:01148 - ubiquitinylated lysine

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Protein features

PBO:0111862 - ubiquitin family protein

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0001972 - abnormal cell separation after cytokinesis resulting in septated cell

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Genotypes:

FYPO:0000059 - abnormal mitotic cell cycle

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Genotypes:

FYPO:0002779 - abolished protein localization to nucleus, with protein mislocalized to cytoplasm, during vegetative growth

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Genotypes:

FYPO:0003244 - decreased mRNA splicing, via spliceosome, intron-specific

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Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

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Genotypes:

FYPO:0001908 - increased pre-mRNA level

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Genotypes:

FYPO:0001490 - inviable elongated vegetative cell

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0001511 - inviable vegetative cell, abnormal cell shape, normal cell size

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Genotypes:

FYPO:0000012 - mitotic G2/M phase transition delay

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Genotypes:

FYPO:0000833 - normal protein level during vegetative growth

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Genotypes:

FYPO:0000838 - normal protein localization to nucleus during vegetative growth

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00240ubiquitinUbiquitin-like_domPfam
cd01791Ubl_UBL5CDD
PS50053UBIQUITIN_2Ubiquitin-like_domPROSITE profiles
G3DSA:3.10.20.90:FF:000052CATH-FunFam
G3DSA:3.10.20.90CATH-Gene3D
SSF54236Ubiquitin-like_domsfSUPERFAMILY
PTHR13042Hub1/Ubl5PANTHER

Orthologs

References / Literature

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:24223771 - New insights into the RNA-based mechanism of action of the anticancer drug 5'-fluorouracil in eukaryotic cells.
Mojardín L et al. PLoS One 2013;8(11):e78172
PMID:28947618 - Sde2 is an intron-specific pre-mRNA splicing regulator activated by ubiquitin-like processing.
Thakran P et al. EMBO J 2018 Jan 04;37(1):89-101
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:28446597 - The histone variant H2A.Z promotes splicing of weak introns.
Nissen KE et al. Genes Dev 2017 Apr 01;31(7):688-701
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:15620657 - Ubiquitin-like protein Hub1 is required for pre-mRNA splicing and localization of an essential splicing factor in fission yeast.
Wilkinson CR et al. Curr Biol 2004 Dec 29;14(24):2283-8
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:15569151 - Hub1 is an essential ubiquitin-like protein without functioning as a typical modifier in fission yeast.
Yashiroda H et al. Genes Cells 2004 Dec;9(12):1189-97