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protein coding gene - gle1 (SPBC31E1.05) - RNA export factor, cytoplasmic nucleoporin Gle1

Gene summary

Standard name
gle1
Systematic ID
SPBC31E1.05
Product
RNA export factor, cytoplasmic nucleoporin Gle1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O94652
ORFeome ID
24/24B02
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 247229..248977 forward strand

Annotation

Disease association

MONDO:0012750 - lethal arthrogryposis-anterior horn cell disease syndrome

References:

MONDO:0009670 - lethal congenital contracture syndrome 1

References:

MONDO:0020128 - motor neuron disorder

References:

MONDO:0005071 - nervous system disorder

References:

GO biological process

GO:0016973 - poly(A)+ mRNA export from nucleus

References:

GO cellular component

GO:0005737 - cytoplasm

References:

GO:0005829 - cytosol

References:

GO:0005635 - nuclear envelope

References:

GO:0034399 - nuclear periphery

References:

GO:0005643 - nuclear pore

References:

GO:0044614 - nuclear pore cytoplasmic filaments

References:

GO:0005634 - nucleus

References:

GO molecular function

GO:0000822 - inositol hexakisphosphate binding

References:

GO:0005543 - phospholipid binding

References:

GO:0031369 - translation initiation factor binding

References:

Modification

MOD:01148 - ubiquitinylated lysine

References:

Multi-locus phenotype

FYPO:0001387 - loss of viability at high temperature

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

Protein sequence feature

SO:0001531 - nuclear_export_signal

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0001407 - decreased cell population growth on glucose carbon source

References:

Genotypes:

FYPO:0000581 - decreased spore germination frequency

References:

Genotypes:

FYPO:0003752 - increased total nuclear polyadenylated mRNA level during vegetative growth

References:

Genotypes:

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

References:

Genotypes:

FYPO:0002263 - inviable after spore germination, without cell division, cell cycle arrest, elongated cell

References:

Genotypes:

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF07817GLE1GLE1PFAM
G3DSA:1.25.40.510:FF:000003FUNFAM
G3DSA:1.25.40.510GLE1-like_sfGENE3D
PTHR12960GLE-1-RELATEDGLE1PANTHER
CoilCoilCOILS
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder
mobidb-lite-Polyampholytedisorder_predictionMOBIDB-Polyampholyte

Orthologs

References / Literature

PMID:15507118 - An interactive gene network for securin-separase, condensin, cohesin, Dis1/Mtc1 and histones constructed by mass transformation.
Yuasa T et al. Genes Cells 2004 Nov;9(11):1069-82
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23695164 - Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.
Das J et al. Sci Signal 2013 May 21;6(276):ra38
PB_REF:0000003 - Disease Association Curation
PMID:31883795 - Positioning Heterochromatin at the Nuclear Periphery Suppresses Histone Turnover to Promote Epigenetic Inheritance.
Holla S et al. Cell 2020 Jan 09;180(1):150-164.e15
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:20970342 - Virtual breakdown of the nuclear envelope in fission yeast meiosis.
Asakawa H et al. Curr Biol 2010 Nov 09;20(21):1919-25
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:18758733 - The fission yeast homologue of Glel is essential for growth and involved in mRNA export.
Moon D et al. J Microbiol 2008 Aug;46(4):422-8