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protein coding gene - srb4 (SPBC31F10.04c) - mediator complex subunit Med17

Gene summary

Standard name
srb4
Systematic ID
SPBC31F10.04c
Product
mediator complex subunit Med17
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
med17
UniProt ID
P87306
ORFeome ID
36/36A12
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 3757414..3759416 reverse strand

Annotation

Disease association

MONDO:0013351 - infantile cerebral and cerebellar atrophy with postnatal progressive microcephaly

References:

MONDO:0005071 - nervous system disorder

References:

GO biological process

GO:0060963 - positive regulation of ribosomal protein gene transcription by RNA polymerase II

References:

GO:0060261 - positive regulation of transcription initiation by RNA polymerase II

References:

GO:0006367 - transcription initiation at RNA polymerase II promoter

References:

GO cellular component

GO:0070847 - core mediator complex

References:

GO:0016592 - mediator complex

References:

GO molecular function

GO:0005515 - protein binding

References:

GO:0016251 - RNA polymerase II general transcription initiation factor activity

References:

GO:0003713 - transcription coactivator activity

References:

Modification

MOD:01149 - sumoylated lysine

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002148 - inviable after spore germination, multiple cell divisions, abnormal morphology

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF10156Med17Med17_NPfam
G3DSA:3.90.1150.120CATH-Gene3D
G3DSA:6.10.250.2620CATH-Gene3D
G3DSA:6.10.250.2630CATH-Gene3D
PTHR13114Mediator_Med17PANTHER
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder
mobidb-lite-Polardisorder_predictionMobiDB-Polar

Orthologs

References / Literature

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:28467824 - Core Mediator structure at 3.4 Å extends model of transcription initiation complex.
Nozawa K et al. Nature 2017 May 11;545(7653):248-251
PMID:15356001 - The Soh1/MED31 protein is an ancient component of Schizosaccharomyces pombe and Saccharomyces cerevisiae Mediator.
Linder T et al. J Biol Chem 2004 Nov 19;279(47):49455-9
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PB_REF:0000003 - Disease Association Curation
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:28515143 - Cyclin C influences the timing of mitosis in fission yeast.
Banyai G et al. Mol Biol Cell 2017 Jul 01;28(13):1738-1744
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.
Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:28060464 - RNA polymerase II components and Rrn7 form a preinitiation complex on the HomolD box to promote ribosomal protein gene expression in Schizosaccharomyces pombe.
Montes M et al. FEBS J 2017 Feb;284(4):615-633
Pfam:PF10156 - Unknown title
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:10625684 - Purification and characterization of RNA polymerase II holoenzyme from Schizosaccharomyces pombe.
Spåhr H et al. J Biol Chem 2000 Jan 14;275(2):1351-6
PMID:28241144 - Mediator structure and rearrangements required for holoenzyme formation.
Tsai KL et al. Nature 2017 Apr 13;544(7649):196-201
PMID:11572939 - Analysis of Schizosaccharomyces pombe mediator reveals a set of essential subunits conserved between yeast and metazoan cells.
Spåhr H et al. Proc Natl Acad Sci U S A 2001 Oct 09;98(21):11985-90
PMID:15182371 - Mediator is required for activated transcription in a Schizosaccharomyces pombe in vitro system.
Tamayo E et al. Eur J Biochem 2004 Jun;271(12):2561-72
PMID:18310102 - Two conserved modules of Schizosaccharomyces pombe Mediator regulate distinct cellular pathways.
Linder T et al. Nucleic Acids Res 2008 May;36(8):2489-504
PMID:34706246 - Cross talk between the upstream exon-intron junction and Prp2 facilitates splicing of non-consensus introns.
Hümmer S et al. Cell Rep 2021 Oct 26;37(4):109893
PMID:23123849 - Structure of the Mediator head module.
Larivière L et al. Nature 2012 Dec 20;492(7429):448-51
PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.
Køhler JB et al. Nat Commun 2015 Nov 05;6:8827
PMID:20622008 - A chromatin-remodeling protein is a component of fission yeast mediator.
Khorosjutina O et al. J Biol Chem 2010 Sep 24;285(39):29729-37
PMID:12738880 - TRAP230/ARC240 and TRAP240/ARC250 Mediator subunits are functionally conserved through evolution.
Samuelsen CO et al. Proc Natl Acad Sci U S A 2003 May 27;100(11):6422-7
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6