protein coding gene - sar1 (SPBC31F10.06c) - Arf family GTPase Sar1

Gene summary

Standard name

sar1

Systematic ID

SPBC31F10.06c

Product

Arf family GTPase Sar1

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

psr1

UniProt ID

Q01475

ORFeome ID

40/40B05

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 3760610..3761885 reverse strand

Annotation

Protein features

Orthologs

• SAR1A (HGNC:10534) Homo sapiens
• SAR1B (HGNC:10535) Homo sapiens
• sar1 (SJAG_00906) Schizosaccharomyces japonicus
• SAR1 (YPL218W) Saccharomyces cerevisiae

References / Literature

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:11839792 - Three proteins required for early steps in the protein secretory pathway also affect nuclear envelope structure and cell cycle progression in fission yeast.

Matynia A et al. J Cell Sci 2002 Jan 15;115(Pt 2):421-31

PMID:1396601 - Fission yeast and a plant have functional homologues of the Sar1 and Sec12 proteins involved in ER to Golgi traffic in budding yeast.

d'Enfert C et al. EMBO J 1992 Nov;11(11):4205-11

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:20603077 - Dephosphorylation of F-BAR protein Cdc15 modulates its conformation and stimulates its scaffolding activity at the cell division site.

Roberts-Galbraith RH et al. Mol Cell 2010 Jul 09;39(1):86-99

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.

GO_REF:0000002 - Comments

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:12631727 - The fission yeast spo14+ gene encoding a functional homologue of budding yeast Sec12 is required for the development of forespore membranes.

Nakamura-Kubo M et al. Mol Biol Cell 2003 Mar;14(3):1109-24

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:34496258 - Transcription and chromatin-based surveillance mechanism controls suppression of cryptic antisense transcription.

Heo DH et al. Cell Rep 2021 Sep 07;36(10):109671

PMID:19139265 - The SH3 domains of two PCH family members cooperate in assembly of the Schizosaccharomyces pombe contractile ring.

Roberts-Galbraith RH et al. J Cell Biol 2009 Jan 12;184(1):113-27

PMID:21445296 - Mis17 is a regulatory module of the Mis6-Mal2-Sim4 centromere complex that is required for the recruitment of CenH3/CENP-A in fission yeast.

Shiroiwa Y et al. PLoS One 2011 Mar 21;6(3):e17761

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:25918164 - Endoplasmic Reticulum Exit of Golgi-resident Defective for SREBP Cleavage (Dsc) E3 Ligase Complex Requires Its Activity.

Raychaudhuri S et al. J Biol Chem 2015 Jun 05;290(23):14430-40

PMID:27432890 - Sar1 localizes at the rims of COPII-coated membranes in vivo.

Kurokawa K et al. J Cell Sci 2016 Sep 01;129(17):3231-7

PMID:33109728 - High-Throughput Identification of Nuclear Envelope Protein Interactions in Schizosaccharomyces pombe Using an Arrayed Membrane Yeast-Two Hybrid Library.

Varberg JM et al. G3 (Bethesda) 2020 Dec 03;10(12):4649-4663

PMID:16272747 - A fission yeast SNAP-25 homologue, SpSec9, is essential for cytokinesis and sporulation.

Nakamura T et al. Cell Struct Funct 2005;30(2):15-24

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Lee J et al. Nat Commun 2017 Feb 20;8:14527

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:18257517 - Phosphoproteome analysis of fission yeast.

Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41