PomBase home

protein coding gene - sar1 (SPBC31F10.06c) - Arf family GTPase Sar1

Gene summary

Standard name
sar1
Systematic ID
SPBC31F10.06c
Product
Arf family GTPase Sar1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
psr1
UniProt ID
Q01475
ORFeome ID
40/40B05
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 3760610..3761885 reverse strand

Annotation

Disease association

MONDO:0009528 - chylomicron retention disease

References:

GO biological process

GO:0032120 - ascospore-type prospore membrane formation

References:

GO:0048208 - COPII vesicle coat assembly

References:

GO:0006888 - endoplasmic reticulum to Golgi vesicle-mediated transport

References:

GO:0006886 - intracellular protein transport

References:

GO cellular component

GO:0030127 - COPII vesicle coat

References:

GO:0005737 - cytoplasm

References:

GO:0005783 - endoplasmic reticulum

References:

GO:0070971 - endoplasmic reticulum exit site

References:

GO:0005789 - endoplasmic reticulum membrane

References:

GO molecular function

GO:0003925 - G protein activity

References:

GO:0005525 - GTP binding

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

MOD:01148 - ubiquitinylated lysine

References:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0004719 - abnormal mitotic cell cycle arrest with condensed chromosomes, septated cell

References:

Genotypes:

FYPO:0001910 - abnormal protein glycosylation during vegetative growth

References:

Genotypes:

FYPO:0003935 - decreased protein localization to Golgi apparatus, with protein mislocalized to endoplasmic reticulum

References:

Genotypes:

FYPO:0008139 - dilated endoplasmic reticulum lumen

References:

Genotypes:

FYPO:0008140 - dilated nuclear envelope lumen

References:

Genotypes:

FYPO:0001784 - excess endoplasmic reticulum membrane present

References:

Genotypes:

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0000516 - normal nuclear import

References:

Genotypes:

FYPO:0008138 - normal nucleocytoplasmic transport

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00025ArfSmall_GTPase_ARF/SARPFAM
cd00879Sar1CDD
PS51422SAR1PROSITE_PROFILES
PS51417ARFPROSITE_PROFILES
SM00177arf_sub_2SMART
SM00178sar_sub_1Small_GTPase_ARF/SARSMART
PR00328SAR1GTPBPSmall_GTPase_ARF/SARPRINTS
G3DSA:3.40.50.300:FF:000161FUNFAM
SSF52540P-loop containing nucleoside triphosphate hydrolasesP-loop_NTPaseSUPERFAMILY
G3DSA:3.40.50.300P-loop_NTPaseGENE3D
PTHR45684RE74312PSmall_GTPase_SAR1PANTHER
TIGR00231small_GTPSmall_GTP-bdNCBIFAM

Orthologs

References / Literature

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000002 - Comments
PMID:18257517 - Phosphoproteome analysis of fission yeast.
Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97
PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.
Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:20603077 - Dephosphorylation of F-BAR protein Cdc15 modulates its conformation and stimulates its scaffolding activity at the cell division site.
Roberts-Galbraith RH et al. Mol Cell 2010 Jul 09;39(1):86-99
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:21445296 - Mis17 is a regulatory module of the Mis6-Mal2-Sim4 centromere complex that is required for the recruitment of CenH3/CENP-A in fission yeast.
Shiroiwa Y et al. PLoS One 2011 Mar 21;6(3):e17761
PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
PMID:33109728 - High-Throughput Identification of Nuclear Envelope Protein Interactions in Schizosaccharomyces pombe Using an Arrayed Membrane Yeast-Two Hybrid Library.
Varberg JM et al. G3 (Bethesda) 2020 Dec 03;10(12):4649-4663
PMID:19139265 - The SH3 domains of two PCH family members cooperate in assembly of the Schizosaccharomyces pombe contractile ring.
Roberts-Galbraith RH et al. J Cell Biol 2009 Jan 12;184(1):113-27
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:34496258 - Transcription and chromatin-based surveillance mechanism controls suppression of cryptic antisense transcription.
Heo DH et al. Cell Rep 2021 Sep 07;36(10):109671
PMID:25918164 - Endoplasmic Reticulum Exit of Golgi-resident Defective for SREBP Cleavage (Dsc) E3 Ligase Complex Requires Its Activity.
Raychaudhuri S et al. J Biol Chem 2015 Jun 05;290(23):14430-40
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:1396601 - Fission yeast and a plant have functional homologues of the Sar1 and Sec12 proteins involved in ER to Golgi traffic in budding yeast.
d'Enfert C et al. EMBO J 1992 Nov;11(11):4205-11
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:11839792 - Three proteins required for early steps in the protein secretory pathway also affect nuclear envelope structure and cell cycle progression in fission yeast.
Matynia A et al. J Cell Sci 2002 Jan 15;115(Pt 2):421-31
PMID:12631727 - The fission yeast spo14+ gene encoding a functional homologue of budding yeast Sec12 is required for the development of forespore membranes.
Nakamura-Kubo M et al. Mol Biol Cell 2003 Mar;14(3):1109-24
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:16272747 - A fission yeast SNAP-25 homologue, SpSec9, is essential for cytokinesis and sporulation.
Nakamura T et al. Cell Struct Funct 2005;30(2):15-24
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.
Lee J et al. Nat Commun 2017 Feb 20;8:14527
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053