protein coding gene - ste11 (SPBC32C12.02) - DNA-binding transcription factor Ste11

Gene summary

Standard name

ste11

Systematic ID

SPBC32C12.02

Product

DNA-binding transcription factor Ste11

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

aff1, stex

UniProt ID

P36631

ORFeome ID

33/33A02

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 3983376..3987400 forward strand

Annotation

Protein features

Orthologs

• ste11 (SJAG_04009) Schizosaccharomyces japonicus

References / Literature

PMID:17032641 - Global roles of Ste11p, cell type, and pheromone in the control of gene expression during early sexual differentiation in fission yeast.

Mata J et al. Proc Natl Acad Sci U S A 2006 Oct 17;103(42):15517-22

PMID:11702950 - Phosphorylation of Mei2 and Ste11 by Pat1 kinase inhibits sexual differentiation via ubiquitin proteolysis and 14-3-3 protein in fission yeast.

Kitamura K et al. Dev Cell 2001 Sep;1(3):389-99

PMID:10467002 - Gene ste20 controls amiloride sensitivity and fertility in Schizosaccharomyces pombe.

Hilti N et al. Curr Genet 1999 Jul;35(6):585-92

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:8668157 - Schizosaccharomyces pombe map1+ encodes a MADS-box-family protein required for cell-type-specific gene expression.

Yabana N et al. Mol Cell Biol 1996 Jul;16(7):3420-8

PMID:39833200 - Centromere positioning orchestrates telomere bouquet formation and the initiation of meiotic differentiation.

Jiménez-Martín A et al. Nat Commun 2025 Jan 20;16(1):837

PMID:36259651 - Structure-based screening for functional non-coding RNAs in fission yeast identifies a factor repressing untimely initiation of sexual differentiation.

Ono Y et al. Nucleic Acids Res 2022 Oct 28;50(19):11229-11242

PMID:22771993 - Distinct requirement of RNA polymerase II CTD phosphorylations in budding and fission yeast.

Cassart C et al. Transcription 2012;3(5):231-4

PMID:32282918 - Genetic interactions and transcriptomics implicate fission yeast CTD prolyl isomerase Pin1 as an agent of RNA 3' processing and transcription termination that functions via its effects on CTD phosphatase Ssu72.

Sanchez AM et al. Nucleic Acids Res 2020 May 21;48(9):4811-4826

PMID:11270572 - Schizosaccharomyces pombe taf1+ is required for nitrogen starvation-induced sexual development and for entering the dormant GO state.

Ueno M et al. Curr Genet 2001 Jan;38(6):307-13

PMID:12697825 - Ste11p, a high-mobility-group box DNA-binding protein, undergoes pheromone- and nutrient-regulated nuclear-cytoplasmic shuttling.

Qin J et al. Mol Cell Biol 2003 May;23(9):3253-64

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:9447985 - Novel factor highly conserved among eukaryotes controls sexual development in fission yeast.

Okazaki N et al. Mol Cell Biol 1998 Feb;18(2):887-95

PMID:1435723 - Functional conservation between Schizosaccharomyces pombe ste8 and Saccharomyces cerevisiae STE11 protein kinases in yeast signal transduction.

Styrkársdóttir U et al. Mol Gen Genet 1992 Oct;235(1):122-30

PMID:34686329 - The Hsp90 cochaperone TTT promotes cotranslational maturation of PIKKs prior to complex assembly.

Toullec D et al. Cell Rep 2021 Oct 19;37(3):109867

PMID:10788621 - Rad24 is essential for proliferation of diploid cells in fission yeast.

Tanaka Y et al. FEBS Lett 2000 Apr 28;472(2-3):254-8

PMID:8846783 - Fission yeast pak1+ encodes a protein kinase that interacts with Cdc42p and is involved in the control of cell polarity and mating.

Ottilie S et al. EMBO J 1995 Dec 01;14(23):5908-19

PMID:17261596 - Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast.

Matsuo T et al. Mol Cell Biol 2007 Apr;27(8):3154-64

PMID:8945514 - Molecular mimicry in development: identification of ste11+ as a substrate and mei3+ as a pseudosubstrate inhibitor of ran1+ kinase.

Li P et al. Cell 1996 Nov 29;87(5):869-80

PMID:28041796 - A PP2A-B55-Mediated Crosstalk between TORC1 and TORC2 Regulates the Differentiation Response in Fission Yeast.

Martín R et al. Curr Biol 2017 Jan 23;27(2):175-188

PMID:7975894 - Mating pheromone-induced expression of the mat1-Pm gene of Schizosaccharomyces pombe: identification of signalling components and characterization of upstream controlling elements.

Aono T et al. Yeast 1994 Jun;10(6):757-70

PMID:21879336 - Multistep regulation of protein kinase A in its localization, phosphorylation and binding with a regulatory subunit in fission yeast.

Gupta DR et al. Curr Genet 2011 Oct;57(5):353-65

PMID:15448137 - Atf1-Pcr1-M26 complex links stress-activated MAPK and cAMP-dependent protein kinase pathways via chromatin remodeling of cgs2+.

Davidson MK et al. J Biol Chem 2004 Dec 03;279(49):50857-63

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:8824587 - Conjugation, meiosis, and the osmotic stress response are regulated by Spc1 kinase through Atf1 transcription factor in fission yeast.

Shiozaki K et al. Genes Dev 1996 Sep 15;10(18):2276-88

PMID:23695302 - Functional characterization of fission yeast transcription factors by overexpression analysis.

Vachon L et al. Genetics 2013 Aug;194(4):873-84

PMID:21072667 - hsf1 (+) extends chronological lifespan through Ecl1 family genes in fission yeast.

Ohtsuka H et al. Mol Genet Genomics 2011 Jan;285(1):67-77

PMID:10908327 - Dmc1 of Schizosaccharomyces pombe plays a role in meiotic recombination.

Fukushima K et al. Nucleic Acids Res 2000 Jul 15;28(14):2709-16

PMID:10867006 - Sequence-specific high mobility group box factors recognize 10-12-base pair minor groove motifs.

van Beest M et al. J Biol Chem 2000 Sep 01;275(35):27266-73

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:9233811 - Cell differentiation by interaction of two HMG-box proteins: Mat1-Mc activates M cell-specific genes in S.pombe by recruiting the ubiquitous transcription factor Ste11 to weak binding sites.

Kjaerulff S et al. EMBO J 1997 Jul 01;16(13):4021-33

PMID:7559598 - Regulation of calcineurin gene expression in Schizosaccharomyces pombe. Dependence on the ste11 transcription factor.

Plochocka-Zulinska D et al. J Biol Chem 1995 Oct 20;270(42):24794-9

PMID:8264618 - Concerted action of RAS and G proteins in the sexual response pathways of Schizosaccharomyces pombe.

Xu HP et al. Mol Cell Biol 1994 Jan;14(1):50-8

PMID:9135083 - Schizosaccharomyces pombe gad7+ encodes a phosphoprotein with a bZIP domain, which is required for proper G1 arrest and gene expression under nitrogen starvation.

Kanoh J et al. Genes Cells 1996 Apr;1(4):391-408

PMID:12471453 - The Schizosaccharomyces pombe genes sep10 and sep11 encode putative general transcriptional regulators involved in multiple cellular processes.

Szilagyi Z et al. Mol Genet Genomics 2002 Dec;268(4):553-62

PMID:10648609 - Novel WD-repeat protein Mip1p facilitates function of the meiotic regulator Mei2p in fission yeast.

Shinozaki-Yabana S et al. Mol Cell Biol 2000 Feb;20(4):1234-42

PMID:29084823 - Phosphorylation of the RNA-binding protein Zfs1 modulates sexual differentiation in fission yeast.

Navarro FJ et al. J Cell Sci 2017 Dec 15;130(24):4144-4154

PMID:9829945 - Methionine induces sexual development in the fission yeast Schizosaccharomyces pombe via an ste11-dependent signalling pathway.

Schweingruber AM et al. J Bacteriol 1998 Dec;180(23):6338-41

PMID:22144909 - The fission yeast stress-responsive MAPK pathway promotes meiosis via the phosphorylation of Pol II CTD in response to environmental and feedback cues.

Sukegawa Y et al. PLoS Genet 2011 Dec;7(12):e1002387

PMID:3185514 - The role of sterility genes (ste and aff) in the initiation of sexual development in Schizosaccharomyces pombe.

Sipiczki M Mol Gen Genet 1988 Aug;213(2-3):529-34

PMID:15713656 - Constitutive activation of the fission yeast pheromone-responsive pathway induces ectopic meiosis and reveals ste11 as a mitogen-activated protein kinase target.

Kjaerulff S et al. Mol Cell Biol 2005 Mar;25(5):2045-59

PMID:12827445 - Cordycepin in Schizosaccharomyces pombe: effects on the wild type and phenotypes of mutants resistant to the drug.

Naula N et al. Curr Genet 2003 Sep;43(6):400-6

PMID:16478992 - Requirement of fission yeast Cid14 in polyadenylation of rRNAs.

Win TZ et al. Mol Cell Biol 2006 Mar;26(5):1710-21

PMID:20634885 - TOR and PKA pathways synergize at the level of the Ste11 transcription factor to prevent mating and meiosis in fission yeast.

Valbuena N et al. PLoS One 2010 Jul 09;5(7):e11514

PMID:22912768 - Rhn1, a nuclear protein, is required for suppression of meiotic mRNAs in mitotically dividing fission yeast.

Sugiyama T et al. PLoS One 2012;7(8):e42962

PMID:11739717 - Protein kinase A regulates sexual development and gluconeogenesis through phosphorylation of the Zn finger transcriptional activator Rst2p in fission yeast.

Higuchi T et al. Mol Cell Biol 2002 Jan;22(1):1-11

PMID:21253571 - H3K9me-independent gene silencing in fission yeast heterochromatin by Clr5 and histone deacetylases.

Hansen KR et al. PLoS Genet 2011 Jan 06;7(1):e1001268

PMID:29079657 - TORC1 and TORC2 converge to regulate the SAGA co-activator in response to nutrient availability.

Laboucarié T et al. EMBO Rep 2017 Dec;18(12):2197-2218

PMID:33711009 - Structure-function analysis of fission yeast cleavage and polyadenylation factor (CPF) subunit Ppn1 and its interactions with Dis2 and Swd22.

Benjamin B et al. PLoS Genet 2021 Mar;17(3):e1009452

PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.

Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:12589433 - Mkp1 and Mkp2, two MAPKAP-kinase homologues in Schizosaccharomyces pombe, interact with the MAP kinase Sty1.

Asp E et al. Mol Genet Genomics 2003 Feb;268(5):585-97

PMID:9236781 - The Schizosaccharomyces pombe mam1 gene encodes an ABC transporter mediating secretion of M-factor.

Christensen PU et al. Mol Gen Genet 1997 Jun;255(2):226-36

PMID:19682301 - A large complex mediated by Moc1, Moc2 and Cpc2 regulates sexual differentiation in fission yeast.

Paul SK et al. FEBS J 2009 Sep;276(18):5076-93

PMID:1657709 - Schizosaccharomyces pombe ste11+ encodes a transcription factor with an HMG motif that is a critical regulator of sexual development.

Sugimoto A et al. Genes Dev 1991 Nov;5(11):1990-9

PMID:12723602 - Characterization of the Prr1 response regulator with special reference to sexual development in Schizosaccharomyces pombe.

Nakamichi N et al. Biosci Biotechnol Biochem 2003 Mar;67(3):547-55

PMID:21642955 - Tra1 has specific regulatory roles, rather than global functions, within the SAGA co-activator complex.

Helmlinger D et al. EMBO J 2011 Jun 03;30(14):2843-52

PMID:25204792 - Sexual development of Schizosaccharomyces pombe is induced by zinc or iron limitation through Ecl1 family genes.

Ohtsuka H et al. Mol Genet Genomics 2015 Feb;290(1):173-85

PMID:8557039 - Schizosaccharomyces pombe atf1+ encodes a transcription factor required for sexual development and entry into stationary phase.

Takeda T et al. EMBO J 1995 Dec 15;14(24):6193-208

PMID:10805744 - Cpc2, a fission yeast homologue of mammalian RACK1 protein, interacts with Ran1 (Pat1) kinase To regulate cell cycle progression and meiotic development.

McLeod M et al. Mol Cell Biol 2000 Jun;20(11):4016-27

PMID:16624901 - A defect in protein farnesylation suppresses a loss of Schizosaccharomyces pombe tsc2+, a homolog of the human gene predisposing to tuberous sclerosis complex.

Nakase Y et al. Genetics 2006 Jun;173(2):569-78

PMID:18257517 - Phosphoproteome analysis of fission yeast.

Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97

PMID:10982411 - A zinc-finger protein, Rst2p, regulates transcription of the fission yeast ste11(+) gene, which encodes a pivotal transcription factor for sexual development.

Kunitomo H et al. Mol Biol Cell 2000 Sep;11(9):3205-17

PMID:34086083 - Expression of Mug14 is regulated by the transcription factor Rst2 through the cAMP-dependent protein kinase pathway in Schizosaccharomyces pombe.

Inamura SI et al. Curr Genet 2021 Oct;67(5):807-821

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:8196631 - Analysis of the structural genes encoding M-factor in the fission yeast Schizosaccharomyces pombe: identification of a third gene, mfm3.

Kjaerulff S et al. Mol Cell Biol 1994 Jun;14(6):3895-905

PMID:38449372 - Regulation of sexual differentiation initiation in Schizosaccharomyces pombe.

Kawamukai M Biosci Biotechnol Biochem 2024 Mar 06;

PMID:10835379 - Schizosaccharomyces pombe Ste7p is required for both promotion and withholding of the entry to meiosis.

Matsuyama A et al. Genetics 2000 Jun;155(2):539-49

PMID:22212525 - Chronological lifespan extension by Ecl1 family proteins depends on Prr1 response regulator in fission yeast.

Ohtsuka H et al. Genes Cells 2012 Jan;17(1):39-52

PMID:22375066 - AMPK phosphorylation by Ssp1 is required for proper sexual differentiation in fission yeast.

Valbuena N et al. J Cell Sci 2012 Jun 01;125(Pt 11):2655-64

PMID:15166138 - A novel gene, msa1, inhibits sexual differentiation in Schizosaccharomyces pombe.

Jeong HT et al. Genetics 2004 May;167(1):77-91

PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.

Paulo JA et al. J Proteomics 2020 Jan 06;210:103531

PMID:8381348 - A Schizosaccharomyces pombe gene that promotes sexual differentiation encodes a helix-loop-helix protein with homology to MyoD.

Benton BK et al. EMBO J 1993 Jan;12(1):135-43

PMID:8536311 - Schizosaccharomyces pombe pac2+ controls the onset of sexual development via a pathway independent of the cAMP cascade.

Kunitomo H et al. Curr Genet 1995 Jun;28(1):32-8

PMID:28671615 - TORC1-Dependent Phosphorylation Targets in Fission Yeast.

Otsubo Y et al. Biomolecules 2017 Jul 03;7(3)

PMID:17046992 - Fission yeast Tor2 promotes cell growth and represses cell differentiation.

Alvarez B et al. J Cell Sci 2006 Nov 01;119(Pt 21):4475-85

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:1766866 - The ste4+ gene, essential for sexual differentiation of Schizosaccharomyces pombe, encodes a protein with a leucine zipper motif.

Okazaki N et al. Nucleic Acids Res 1991 Dec;19(25):7043-7

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:9671458 - An RNA binding protein negatively controlling differentiation in fission yeast.

Tsukahara K et al. Mol Cell Biol 1998 Aug;18(8):4488-98

PMID:7791776 - Characterization of fus1 of Schizosaccharomyces pombe: a developmentally controlled function needed for conjugation.

Petersen J et al. Mol Cell Biol 1995 Jul;15(7):3697-707

PMID:18422613 - A novel gene, ecl1(+), extends the chronological lifespan in fission yeast.

Ohtsuka H et al. FEMS Yeast Res 2008 Jun;8(4):520-30

PMID:22900017 - The fission yeast GATA factor, Gaf1, modulates sexual development via direct down-regulation of ste11+ expression in response to nitrogen starvation.

Kim L et al. PLoS One 2012;7(8):e42409

PMID:37788281 - A dominant negative 14-3-3 mutant in Schizosaccharomyces pombe distinguishes the binding proteins involved in sexual differentiation and check point.

Ohshima T et al. PLoS One 2023;18(10):e0291524

PMID:1934121 - Pheromone production and response in sterile mutants of fission yeast.

Leupold U et al. Curr Genet 1991 Jul;20(1-2):79-85

PMID:14745200 - Truncated Sla1 induces haploid meiosis through the Pat1-Mei2 system in fission yeast.

Tanabe K et al. Biosci Biotechnol Biochem 2004 Jan;68(1):266-70

PMID:20605454 - A gene-specific requirement of RNA polymerase II CTD phosphorylation for sexual differentiation in S. pombe.

Coudreuse D et al. Curr Biol 2010 Jun 22;20(12):1053-64

PMID:8168486 - A zinc finger protein controls the onset of premeiotic DNA synthesis of fission yeast in a Mei2-independent cascade.

Sugiyama A et al. EMBO J 1994 Apr 15;13(8):1881-7

PMID:11129048 - The Prr1 response regulator is essential for transcription of ste11+ and for sexual development in fission yeast.

Ohmiya R et al. Mol Gen Genet 2000 Nov;264(4):441-51

PMID:12664134 - Inactivation of Ran1/Pat1 kinase bypasses the requirement for high-level expression of mei2 during fission yeast meiosis.

Peng Z et al. Curr Genet 2003 Jun;43(3):178-85

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:21307597 - Ecl1, a regulator of the chronological lifespan of Schizosaccharomyces pombe, is induced upon nitrogen starvation.

Miwa Y et al. Biosci Biotechnol Biochem 2011;75(2):279-83

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:19056896 - The S. pombe SAGA complex controls the switch from proliferation to sexual differentiation through the opposing roles of its subunits Gcn5 and Spt8.

Helmlinger D et al. Genes Dev 2008 Nov 15;22(22):3184-95

PMID:8557102 - Stress signal, mediated by a Hog1-like MAP kinase, controls sexual development in fission yeast.

Kato T et al. FEBS Lett 1996 Jan 15;378(3):207-12

PMID:22253882 - The RNA binding protein Csx1 promotes sexual differentiation in Schizosaccharomyces pombe.

Matia-Gonzalez AM et al. PLoS One 2012;7(1):e30067

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.

Mata J et al. Nat Genet 2002 Sep;32(1):143-7

PMID:11554925 - The RGS domain-containing fission yeast protein, Rgs1p, regulates pheromone signalling and is required for mating.

Pereira PS et al. Genes Cells 2001 Sep;6(9):789-802

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:9560432 - Exogenous inositol and genes responsible for inositol transport are required for mating and sporulation in Shizosaccharomyces pombe.

Niederberger C et al. Curr Genet 1998 Apr;33(4):255-61

PMID:16550352 - A starvation-specific serine protease gene, isp6+, is involved in both autophagy and sexual development in Schizosaccharomyces pombe.

Nakashima A et al. Curr Genet 2006 Jun;49(6):403-13

PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.

Egan ED et al. RNA 2014 Jun;20(6):867-81

PMID:18059475 - Cdc2p controls the forkhead transcription factor Fkh2p by phosphorylation during sexual differentiation in fission yeast.

Shimada M et al. EMBO J 2008 Jan 09;27(1):132-42

PMID:29316864 - Overexpression of the transcription factor Rst2 in Schizosaccharomyces pombe indicates growth defect, mitotic defects, and microtubule disorder.

Takenaka K et al. Biosci Biotechnol Biochem 2018 Feb;82(2):247-257

PMID:17295836 - Fission yeast autophagy induced by nitrogen starvation generates a nitrogen source that drives adaptation processes.

Kohda TA et al. Genes Cells 2007 Feb;12(2):155-70

PMID:8552099 - Schizosaccharomyces pombe pcr1+ encodes a CREB/ATF protein involved in regulation of gene expression for sexual development.

Watanabe Y et al. Mol Cell Biol 1996 Feb;16(2):704-11

PMID:28388826 - Sulfur restriction extends fission yeast chronological lifespan through Ecl1 family genes by downregulation of ribosome.

Ohtsuka H et al. Mol Microbiol 2017 Jul;105(1):84-97