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protein coding gene - pch1 (SPBC32F12.06) - P-TEFB associated cyclin, cyclin T Pch1

Gene summary

Standard name
pch1
Systematic ID
SPBC32F12.06
Product
P-TEFB associated cyclin, cyclin T Pch1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O74627
ORFeome ID
40/40C12
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 2794821..2797457 forward strand

Annotation

Disease association

MONDO:0010408 - syndactyly-telecanthus-anogenital and renal malformations syndrome

References:

GO biological process

GO:0032786 - positive regulation of DNA-templated transcription, elongation

References:

GO:0045944 - positive regulation of transcription by RNA polymerase II

References:

GO:0023052 - signaling

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GO cellular component

GO:0000307 - cyclin-dependent protein kinase holoenzyme complex

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GO:0005829 - cytosol

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GO:0005634 - nucleus

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GO:0070691 - P-TEFb complex

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GO molecular function

GO:0061575 - cyclin-dependent protein serine/threonine kinase activator activity

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GO:0005515 - protein binding

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Modification

MOD:00046 - O-phospho-L-serine

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MOD:00047 - O-phospho-L-threonine

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MOD:00696 - phosphorylated residue

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Protein features

PBO:0111794 - cyclin

Qualitative gene expression

PomGeneEx:0000016 - RNA level constant

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PomGeneEx:0000014 - RNA present

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000151 - abnormal meiotic chromosome segregation

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Genotypes:

FYPO:0000229 - cut

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Genotypes:

FYPO:0006661 - fragmented nucleus

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Genotypes:

FYPO:0001406 - increased septum thickness

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Genotypes:

FYPO:0002148 - inviable after spore germination, multiple cell divisions, abnormal morphology

References:

Genotypes:

FYPO:0002250 - inviable curved vacuolated vegetative cell

References:

Genotypes:

FYPO:0002303 - inviable mononucleate monoseptate vegetative cell with anucleate compartment

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF00134Cyclin_NCyclin_NPfam
PF02984Cyclin_CCyclin_C-domPfam
cd20545CYCLIN_SpCG1C-like_rpt1CDD
cd20546CYCLIN_SpCG1C_ScCTK2-like_rpt2CDD
SM00385CYCLINCyclin-like_domSMART
G3DSA:1.10.472.10:FF:000072CATH-FunFam
G3DSA:1.10.472.10CATH-Gene3D
SSF47954Cyclin-like_sfSUPERFAMILY
PTHR10026Cyclin/Ssn8PANTHER
PIRSF036580Cyclin_LPIRSF
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder
mobidb-lite-Polardisorder_predictionMobiDB-Polar
mobidb-lite-Polyampholytedisorder_predictionMobiDB-Polyampholyte

Orthologs

References / Literature

PMID:9115279 - Pch1(+), a second essential C-type cyclin gene in Schizosaccharomyces pombe.
Furnari BA et al. J Biol Chem 1997 May 02;272(18):12100-6
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:27984725 - CDK Substrate Phosphorylation and Ordering the Cell Cycle.
Swaffer MP et al. Cell 2016 Dec 15;167(7):1750-1761.e16
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:22508988 - Separate domains of fission yeast Cdk9 (P-TEFb) are required for capping enzyme recruitment and primed (Ser7-phosphorylated) Rpb1 carboxyl-terminal domain substrate recognition.
St Amour CV et al. Mol Cell Biol 2012 Jul;32(13):2372-83
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:12904290 - Characterization of the Schizosaccharomyces pombe Cdk9/Pch1 protein kinase: Spt5 phosphorylation, autophosphorylation, and mutational analysis.
Pei Y et al. J Biol Chem 2003 Oct 31;278(44):43346-56
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.
Egan ED et al. RNA 2014 Jun;20(6):867-81
PMID:29899453 - A Cdk9-PP1 switch regulates the elongation-termination transition of RNA polymerase II.
Parua PK et al. Nature 2018 Jun;558(7710):460-464
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
GO_REF:0000051 - S. pombe keyword mapping
PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.
Lee J et al. Nat Commun 2017 Feb 20;8:14527
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:18257517 - Phosphoproteome analysis of fission yeast.
Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97
PMID:16428435 - Cyclin-dependent kinase 9 (Cdk9) of fission yeast is activated by the CDK-activating kinase Csk1, overlaps functionally with the TFIIH-associated kinase Mcs6, and associates with the mRNA cap methyltransferase Pcm1 in vivo.
Pei Y et al. Mol Cell Biol 2006 Feb;26(3):777-88
PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.
Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85
PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.
Blyth J et al. Genetics 2018 Feb;208(2):589-603
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:12475973 - Interactions between fission yeast Cdk9, its cyclin partner Pch1, and mRNA capping enzyme Pct1 suggest an elongation checkpoint for mRNA quality control.
Pei Y et al. J Biol Chem 2003 Feb 28;278(9):7180-8