protein coding gene - gem7 (SPBC32F12.16) - SMN complex subunit Gem7

Gene summary

Standard name: gem7
Systematic ID: SPBC32F12.16
Product: SMN complex subunit Gem7
Organism: Schizosaccharomyces pombe (fission yeast)
Synonyms: new17
UniProt ID: G2TRR1
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome II: 2788470..2788887 forward strand

Annotation

GO biological process

GO:0000387 - spliceosomal snRNP assembly

References:

PMID:33754639

GO cellular component

GO:0005634 - nucleus

References:

GO_REF:0000024

GO:0032797 - SMN complex

References:

PMID:33754639

GO molecular function

GO:0003723 - RNA binding

References:

GO_REF:0000002

Quantitative gene expression

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0002059 - inviable cell population

References:

PMID:33754639

Genotypes:

gem7delta

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0000055 - no apparent S. cerevisiae ortholog

Warnings

PBO:0000082 - new gene

References:

Protein features

ID	Name	InterPro name	DB name
PF11095	Gemin7	SMN_gemin7	PFAM
PS52002	SM	Sm	PROSITE_PROFILES
G3DSA:2.30.30.100			GENE3D
PTHR14679	GEM-ASSOCIATED PROTEIN 7	SMN_gemin7	PANTHER

Orthologs

GEMIN7 (HGNC:20045) Homo sapiens
gem7 (SJAG_01217) Schizosaccharomyces japonicus

References / Literature

PMID:26896847 - Ensembl comparative genomics resources.: Herrero J et al. Database (Oxford) 2016;2016
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:21270388 - Augmented annotation of the Schizosaccharomyces pombe genome reveals additional genes required for growth and viability.: Bitton DA et al. Genetics 2011 Apr;187(4):1207-17
PMID:33754639 - Identification and structural analysis of the Schizosaccharomyces pombe SMN complex.: Veepaschit J et al. Nucleic Acids Res 2021 Jul 21;49(13):7207-7223
GO_REF:0000002 - Comments
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83