protein coding gene - mei4 (SPBC32H8.11) - DNA-binding forkhead transcription factor, meiotic Mei4

Gene summary

Standard name

mei4

Systematic ID

SPBC32H8.11

Product

DNA-binding forkhead transcription factor, meiotic Mei4

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

dot4, pi013, SPACTOKYO_453.23

UniProt ID

O13606

ORFeome ID

50/50G12

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 1473068..1475285 forward strand

Annotation

Protein features

Orthologs

• mei4 (SJAG_05288) Schizosaccharomyces japonicus
• HCM1 (YCR065W) Saccharomyces cerevisiae

References / Literature

PMID:24569997 - Characterization of Schizosaccharomyces pombe copper transporter proteins in meiotic and sporulating cells.

Plante S et al. J Biol Chem 2014 Apr 04;289(14):10168-81

PMID:11895484 - Meu10 is required for spore wall maturation in Schizosaccharomyces pombe.

Tougan T et al. Genes Cells 2002 Feb;7(2):217-31

PMID:26670050 - Regulation of mRNA Levels by Decay-Promoting Introns that Recruit the Exosome Specificity Factor Mmi1.

Kilchert C et al. Cell Rep 2015 Dec 22;13(11):2504-2515

PMID:12759375 - Fission yeast meu14+ is required for proper nuclear division and accurate forespore membrane formation during meiosis II.

Okuzaki D et al. J Cell Sci 2003 Jul 01;116(Pt 13):2721-35

PMID:18815595 - Promoter-driven splicing regulation in fission yeast.

Moldón A et al. Nature 2008 Oct 16;455(7215):997-1000

PMID:16272747 - A fission yeast SNAP-25 homologue, SpSec9, is essential for cytokinesis and sporulation.

Nakamura T et al. Cell Struct Funct 2005;30(2):15-24

PMID:14871934 - ADAM family protein Mde10 is essential for development of spore envelopes in the fission yeast Schizosaccharomyces pombe.

Nakamura T et al. Eukaryot Cell 2004 Feb;3(1):27-39

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:26942678 - Enhancer of Rudimentary Cooperates with Conserved RNA-Processing Factors to Promote Meiotic mRNA Decay and Facultative Heterochromatin Assembly.

Sugiyama T et al. Mol Cell 2016 Mar 03;61(5):747-759

PMID:40185772 - A bifunctional snoRNA with separable activities in guiding rRNA 2'-O-methylation and scaffolding gametogenesis effectors.

Leroy E et al. Nat Commun 2025 Apr 05;16(1):3250

PMID:17804800 - Mei4p coordinates the onset of meiosis I by regulating cdc25+ in fission yeast.

Murakami-Tonami Y et al. Proc Natl Acad Sci U S A 2007 Sep 11;104(37):14688-93

PMID:15238514 - Conserved and nonconserved proteins for meiotic DNA breakage and repair in yeasts.

Young JA et al. Genetics 2004 Jun;167(2):593-605

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.

Roguev A et al. Science 2008 Oct 17;322(5900):405-10

PMID:33536434 - A scaffold lncRNA shapes the mitosis to meiosis switch.

Andric V et al. Nat Commun 2021 Feb 03;12(1):770

PMID:29084823 - Phosphorylation of the RNA-binding protein Zfs1 modulates sexual differentiation in fission yeast.

Navarro FJ et al. J Cell Sci 2017 Dec 15;130(24):4144-4154

PMID:21449049 - A novel fission yeast mei4 mutant that allows efficient synchronization of telomere dispersal and the first meiotic division.

Kakui Y et al. Yeast 2011 Jun;28(6):467-79

PMID:21317872 - Red1 promotes the elimination of meiosis-specific mRNAs in vegetatively growing fission yeast.

Sugiyama T et al. EMBO J 2011 Mar 16;30(6):1027-39

PMID:22912768 - Rhn1, a nuclear protein, is required for suppression of meiotic mRNAs in mitotically dividing fission yeast.

Sugiyama T et al. PLoS One 2012;7(8):e42962

PMID:23658229 - Red5 and three nuclear pore components are essential for efficient suppression of specific mRNAs during vegetative growth of fission yeast.

Sugiyama T et al. Nucleic Acids Res 2013 Jul;41(13):6674-86

PMID:29424342 - YTH-RNA-binding protein prevents deleterious expression of meiotic proteins by tethering their mRNAs to nuclear foci.

Shichino Y et al. Elife 2018 Feb 09;7

PMID:21215368 - The Cul4-Ddb1(Cdt)² ubiquitin ligase inhibits invasion of a boundary-associated antisilencing factor into heterochromatin.

Braun S et al. Cell 2011 Jan 07;144(1):41-54

PMID:22558440 - Cuf2 is a novel meiosis-specific regulatory factor of meiosis maturation.

Ioannoni R et al. PLoS One 2012;7(4):e36338

PMID:11405625 - A novel Cdc20-related WD-repeat protein, Fzr1, is required for spore formation in Schizosaccharomyces pombe.

Asakawa H et al. Mol Genet Genomics 2001 May;265(3):424-35

PMID:25492408 - Meiotic nuclear movements in fission yeast are regulated by the transcription factor Mei4 downstream of a Cds1-dependent replication checkpoint pathway.

Ruan K et al. Genes Cells 2015 Mar;20(3):160-72

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:21775631 - The fission yeast pleckstrin homology domain protein Spo7 is essential for initiation of forespore membrane assembly and spore morphogenesis.

Nakamura-Kubo M et al. Mol Biol Cell 2011 Sep;22(18):3442-55

PMID:3861929 - Characterization of meiosis-deficient mutants by electron microscopy and mapping of four essential genes in the fission yeast Schizosaccharomyces pombe.

Shimoda C et al. Mol Gen Genet 1985;200(2):252-7

PMID:3870979 - ran1+ controls the transition from mitotic division to meiosis in fission yeast.

Beach D et al. Curr Genet 1985;10(4):297-311

PMID:12786945 - Overlapping omt1+ and omt2+ genes are required for spore wall maturation in Schizosaccharomyces pombe.

Kakihara Y et al. Genes Cells 2003 Jun;8(6):547-58

PMID:14648198 - DSC1-MCB regulation of meiotic transcription in Schizosaccharomyces pombe.

Cunliffe L et al. Mol Genet Genomics 2004 Feb;271(1):60-71

PMID:17927811 - Transcriptional regulatory network for sexual differentiation in fission yeast.

Mata J et al. Genome Biol 2007;8(10):R217

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:24210919 - Mtr4-like protein coordinates nuclear RNA processing for heterochromatin assembly and for telomere maintenance.

Lee NN et al. Cell 2013 Nov 21;155(5):1061-74

PMID:26804917 - Spatiotemporal Control of Forkhead Binding to DNA Regulates the Meiotic Gene Expression Program.

Alves-Rodrigues I et al. Cell Rep 2016 Feb 02;14(4):885-895

PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.

Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101

PMID:18059475 - Cdc2p controls the forkhead transcription factor Fkh2p by phosphorylation during sexual differentiation in fission yeast.

Shimada M et al. EMBO J 2008 Jan 09;27(1):132-42

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:21504829 - Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Stewart EV et al. Mol Cell 2011 Apr 22;42(2):160-71

PMID:31974447 - Formation of S. pombe Erh1 homodimer mediates gametogenic gene silencing and meiosis progression.

Hazra D et al. Sci Rep 2020 Jan 23;10(1):1034

PMID:24727291 - A genome-wide screen for sporulation-defective mutants in Schizosaccharomyces pombe.

Ucisik-Akkaya E et al. G3 (Bethesda) 2014 Apr 11;4(6):1173-82

PMID:9528784 - The Schizosaccharomyces pombe mei4+ gene encodes a meiosis-specific transcription factor containing a forkhead DNA-binding domain.

Horie S et al. Mol Cell Biol 1998 Apr;18(4):2118-29

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:10747048 - Autoregulated expression of Schizosaccharomyces pombe meiosis-specific transcription factor Mei4 and a genome-wide search for its target genes.

Abe H et al. Genetics 2000 Apr;154(4):1497-508

PMID:7498766 - The role of cdc2 and other genes in meiosis in Schizosaccharomyces pombe.

Iino Y et al. Genetics 1995 Aug;140(4):1235-45

PMID:24920274 - Meiotic long non-coding meiRNA accumulates as a dot at its genetic locus facilitated by Mmi1 and plays as a decoy to lure Mmi1.

Shichino Y et al. Open Biol 2014 Jun;4(6):140022

PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.

Mata J et al. Nat Genet 2002 Sep;32(1):143-7

PMID:26986212 - Cuf2 Is a Transcriptional Co-Regulator that Interacts with Mei4 for Timely Expression of Middle-Phase Meiotic Genes.

Ioannoni R et al. PLoS One 2016;11(3):e0151914

PMID:28841135 - Ubiquitination-dependent control of sexual differentiation in fission yeast.

Simonetti F et al. Elife 2017 Aug 25;6

PMID:32101745 - Dense Transposon Integration Reveals Essential Cleavage and Polyadenylation Factors Promote Heterochromatin Formation.

Lee SY et al. Cell Rep 2020 Feb 25;30(8):2686-2698.e8

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.

Egan ED et al. RNA 2014 Jun;20(6):867-81

PMID:33574613 - TOR targets an RNA processing network to regulate facultative heterochromatin, developmental gene expression and cell proliferation.

Wei Y et al. Nat Cell Biol 2021 Mar;23(3):243-256

PMID:11901107 - Fission yeast mutants affecting telomere clustering and meiosis-specific spindle pole body integrity.

Jin Y et al. Genetics 2002 Mar;160(3):861-76

PMID:11739743 - Novel fission yeast Cdc7-Dbf4-like kinase complex required for the initiation and progression of meiotic second division.

Nakamura T et al. Mol Cell Biol 2002 Jan;22(1):309-20

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:25076038 - Large scale screening of genetic interaction with sgf73(+) in fission yeast.

Guo Y et al. Yi Chuan 2014 Jul;36(7):723-31

PMID:28765164 - Selective termination of lncRNA transcription promotes heterochromatin silencing and cell differentiation.

Touat-Todeschini L et al. EMBO J 2017 Sep 01;36(17):2626-2641

PMID:28545058 - A systematic genomic screen implicates nucleocytoplasmic transport and membrane growth in nuclear size control.

Kume K et al. PLoS Genet 2017 May;13(5):e1006767

PMID:28476936 - Genome-wide screen for cell growth regulators in fission yeast.

Weston L et al. J Cell Sci 2017 Jun 15;130(12):2049-2055

PMID:23843742 - Quantitative control of protein S-palmitoylation regulates meiotic entry in fission yeast.

Zhang MM et al. PLoS Biol 2013 Jul;11(7):e1001597

PMID:22144463 - RNA elimination machinery targeting meiotic mRNAs promotes facultative heterochromatin formation.

Zofall M et al. Science 2012 Jan 06;335(6064):96-100

PMID:23980030 - A novel factor Iss10 regulates Mmi1-mediated selective elimination of meiotic transcripts.

Yamashita A et al. Nucleic Acids Res 2013 Nov;41(21):9680-7

PMID:26518661 - The Paf1 complex factors Leo1 and Paf1 promote local histone turnover to modulate chromatin states in fission yeast.

Sadeghi L et al. EMBO Rep 2015 Dec;16(12):1673-87

PMID:27365210 - The fission yeast MTREC and EJC orthologs ensure the maturation of meiotic transcripts during meiosis.

Marayati BF et al. RNA 2016 Sep;22(9):1349-59

PMID:29123917 - The telomere bouquet facilitates meiotic prophase progression and exit in fission yeast.

Moiseeva V et al. Cell Discov 2017;3:17041

PMID:32012158 - Meiotic gene silencing complex MTREC/NURS recruits the nuclear exosome to YTH-RNA-binding protein Mmi1.

Shichino Y et al. PLoS Genet 2020 Feb;16(2):e1008598

PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.

Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684

PMID:20531409 - Global coordination of transcriptional control and mRNA decay during cellular differentiation.

Amorim MJ et al. Mol Syst Biol 2010 Jun 08;6:380

PMID:16823445 - Selective elimination of messenger RNA prevents an incidence of untimely meiosis.

Harigaya Y et al. Nature 2006 Jul 06;442(7098):45-50

PMID:10855500 - Characterization of fission yeast meiotic mutants based on live observation of meiotic prophase nuclear movement.

Hiraoka Y et al. Chromosoma 2000;109(1-2):103-9

PMID:25486473 - Regulation of wee1(+) expression during meiosis in fission yeast.

Murakami-Tonami Y et al. Cell Cycle 2014;13(18):2853-8

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:16762840 - Swi6/HP1 recruits a JmjC domain protein to facilitate transcription of heterochromatic repeats.

Zofall M et al. Mol Cell 2006 Jun 09;22(5):681-92